Regulatory Mechanisms in Breast Cancer : Advances in Cellular and Molecular Biology of Breast Cancer

I. Oncogenes, antioncogenes, and tumor prognosis.- 1. Oncogenes as clinical prognostic indicators.- 2. Role of the retinoblastoma gene in the oncogenesis of human breast carcinoma.- II. Growth factors and their receptors.- 3. Relationship of growth factors and differentiation in normal and neoplastic development of the mammary gland.- 4. Local effects of growth factors.- 5. The insulin-like growth factors, their receptors, and their binding proteins in human breast cancer.- 6. The role of ras gene expression and transforming growth factor ? production in the etiology and progression of rodent and human breast cancer.- 7. The role of epidermal growth factor receptors in breast cancer.- 8. Cell proliferation in metazoans: Negative control mechanisms.- III. Estrogen and antiestrogens.- 9. Steroid modulation of the expression of growth factors and oncogenes in breast cancer.- 10. Antiestrogen therapy for breast cancer: Current strategies and potential causes for therapeutic failure.- 11. Steroidal pure antiestrogens.- 12. Estrogen-regulated messenger RNAs in human breast cancer cells.- 13. Estrogen and progesterone receptors.- 14. Growth factors as mediators of estrogen/antiestrogen action in human breast cancer cells.- 15. Steroids, growth factors, and cell cycle controls in breast cancer.- IV. Stromal-epithelial interactions and metastases.- 16. Stromal regulation of epithelial function.- 17. Mammary epithelial cells, extracellular matrix, and gene expression.- 18. Tenascin in mammary gland development: From embryogenesis to carcinogenesis.- 19. Stromal-epithelial interactions in normal and neoplastic mammary gland.- 20. Extracellular matrix metalloproteinases in tumor invasion and metastasis.