Presenting the proceedings of a symposium held in honour of Professor Ullrich Trendelenburg, this text is concerned with research on the pharmacology and physiology of such neurotransmitters as noradrenaline, dopmanine, 5-hydroxytrypemine and ATP. The articles have been written by specialists in the field of transmitter pharmacology. It is hoped that the new research activities and results they report on will advance understanding about the autonomic nervous system.
Synthesis and inactivation of neurotransmitters.- The effects of electroconvulsive shock on catecholamine function in the locus ceruleus and hippocampus.- Molecular aspects of the neuronal noradrenaline transporter.- Energy requirements for the basal efflux of noradrenaline and its metabolites from adrenergic varicosities.- The effects of type 1 diabetes mellitus and of tobacco smoke on dissipation of catecholamines in pulmonary endothelial cells - a non-neuronal site of uptake1.- Distribution of extraneuronal uptake1 in reproductive tissues: studies on cells in culture.- Extraneuronal inactivation of noradrenaline in tissue culture.- The influence of the estrous cycle on the accumulation of 3H-noradrenaline in rat uterus and on efflux of radioactivity from the uterus.- PC12 cells as a window for the differentiation of neural crest into adrenergic nerve ending and adrenal medulla.- Clinical aspects on presynaptic noradrenaline metabolism.- Effects of imipramine and some tryptamine derivatives on the efflux of 3H-5-hydroxytryptamine from rabbit platelets.- Influence of antidepressant drugs on seizure susceptibility and the anticonvulsant activity of valproate in mice.- Neurotransmitter release and co-transmission.- Noradrenaline-ATP corelease and cotransmission following activation of nicotine receptors at postganglionic sympathetic axons.- Preliminary evidence for noradrenaline and ATP as neurotransmitters in the porcine isolated palmar common digital artery.- Involvement of catecholaminergic neurones of the nucleus of the solitary tract (NTS) in blood pressure regulation.- Vasodilatation by endothelium-derived nitric oxide as a major determinant of noradrenaline release.- Stimulation of noradrenaline release in the cerebral cortex via presynaptic N-methyl-D-aspartate (NMDA) receptors and their pharmacological characterization.- Presynaptic modulation of neurotransmitter release by endogenous angiotensin II in brown adipose tissue.- Selective destruction of preganglionic sympathetic nerves by antibodies to acetylcholinesterase.- Receptors and post-receptor events.- Adenosine receptors in the central nervous system.- Mediation by adenosine of the trophic effects exerted by the sympathetic innervation of blood vessels.- Alpha1- and alpha2-adrenoceptors at different levels of the canine saphenous vein.- Pre- and postsynaptic alpha2 adrenoceptors as target for drug discovery.- Cyclic AMP and adaptive supersensitivity in guinea pig atria.- Molecular aspects of the receptor activation by imidazolines: an overview.- 5-HT4-like receptors in mammalian atria.- Glutamate receptor antagonism: neurotoxicity, anti-akinetic effects and psychosis.- Stereotypy and asymmetry in mice.
Series: Journal of Neural Transmission. Supplementa
Number Of Pages: 221
Published: December 1991
Publisher: SPRINGER VERLAG GMBH
Country of Publication: AT
Dimensions (cm): 27.94 x 20.96
Weight (kg): 0.54