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Radiation and the Gastrointestinal Tract - Andre Dubois

Radiation and the Gastrointestinal Tract

Hardcover Published: 22nd November 1994
ISBN: 9780849376672
Number Of Pages: 297

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This book evolved from a two-day 1993 International Symposium on Radiation and the Gastrointestinal Tract held at the Uniformed Services University of the Health Sciences, Bethesda, Maryland. This area of investigation is particularly important because of growing medical needs and the documented occurrence of accidents involving overexposure of healthy subjects/patients. Some questions have been answered through cellular and animal research-results that lead to hypotheses that have been tested through clinical protocols. In an attempt to answer the unresolved questions, basic scientists and clinicians describe the data obtained to date, present in a critical manner the consensus that has been reached, and discuss what still remains to be investigated.
The book is divided into five parts: Overview and Clinical Perspective, Emesis, Motility, Diarrhea, and Behavioral Correlates of Gastrointestinal Dysfunction. Each part consists of separate discussions on the pathophysiology, the methodology, and, when applicable, the clinical relevance of the observations.
The book provides helpful information to both basic scientists involved in radiobiological research and to clinicians caring for patients exposed to radiation. It also serves as an introduction to the subject for young clinical investigators interested in the field and for scientists searching for correlates between their observations and disorders of the gastrointestinal tract.

Clinical Aspects of Irradiation-Induced Alimentary Tract Injuryp. 3
Radiation-Induced Emesis in Animal Modelsp. 23
Differences in Anti-Emetic Predictability Among 5-HT[subscript 3] Receptor Antagonist Drugsp. 37
Clinical Trials with Ondansetron in Radiation-Induced Emesisp. 51
Radiation-Induced Gastric Dysfunctionp. 63
Postirradiation Alterations in Small and Large Bowel Motilityp. 77
Nitric Oxide and Smooth Muscle Relaxation in the Intestine. Chemical and Radiation Effects Measured by EPR/Spin Trappingp. 89
Neurochemical Changes in the Irradiated Brain-Gut Axisp. 101
Radiation-Induced Changes to Epithelial and Non-Epithelial Tissuep. 113
Molecular Mechanisms of Cellular Radioresistance and Radiosensitivityp. 129
The Effect of Radiation on Intestinal Electrolyte Transportp. 149
Nearby Shielding Influences Survival of the Irradiated Intestinep. 161
Modification of Radiation Injury to the Intestine by Eicosanoids and Thiol Radioprotectorsp. 171
Effect of Radioprotective Agents on Survival after Acute Intestinal Radiation Injuryp. 183
Nutritional Support of Irradiated Intestinep. 201
Chemotherapy and Radiation Protection with Amifostine: Clinical Studiesp. 215
Gastrointestinal Syndrome after Accidental Overexposure During Radiotherapyp. 225
Effects of Different Types of Radiation on Emesis and Taste Aversion Learningp. 237
Behavioral Assessment of Antiemetic Drugs in Ratsp. 251
Behavioral Implications of Radiation- and Drug-Induced Gastrointestinal Distressp. 267
Indexp. 275
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780849376672
ISBN-10: 084937667X
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 297
Published: 22nd November 1994
Country of Publication: US
Dimensions (cm): 22.86 x 15.88  x 1.91
Weight (kg): 0.64
Edition Number: 1

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