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Quantitative Methods in Neuroscience : A Neuroanatomical Approach - Stephen M Evans

Quantitative Methods in Neuroscience

A Neuroanatomical Approach

By: Stephen M Evans (Editor), Ann Marie Janson (Editor), Jens Randel Nyengaard (Editor)

Hardcover Published: 1st August 2004
ISBN: 9780198505280
Number Of Pages: 350

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Stereology is a valuable tool for neuroscientists, allowing them to obtain 3-Dimensional information from 2-Dimensional measurements made on appropriately sampled sections (usually obtained from histological sections or MRI/CT/PET scans). This 3-D information is invaluable in correlating structural/functional relationships in the pursuit of far greater understanding of the function of the central nervous system. However, in carrying out such measurements, often based on limited data sets, there is a risk of experimenter bias. An important feature of modern design based stereology is to be aware of potential sources of bias and eliminate them during the data collection. With many of the major neuroscience journals now insisting that quantitative data be presented, there is a greater need than ever for neuroscientists to understand the theory and practice behind quantitative methods, such as those offered by stereology. Quantitive Methods in Neuroscience is a cookbook of stereological methods written especially for neuroscientists. It provides clear and accessible advice about when and when not to use stereology. Throughout the book, the emphasis is on practical guidance, rather than discussions and formulae. Written by leading scientists in the field of stereology, with a Foreword by D.C. Sterio, the book will be a valuable introduction to these methods for neuroscientists, and all those involved in development of new drug programmes.

Industry Reviews

The book is a practical tool for the increasingly large number of neuroscientists who require specific stereological techniques. It is both informative and valuable, in that it suggests appropriate methods and statistical treatments for resolving particular types of stereological problems. Physiology News, No 57

1: Stephen M. Evans & Jens Randel Nyengaard: Introduction 2: Luis Cruz-Orive, A.M. Insausti, R. Insausti & D. Crespo: A case study from neuroscience involving stereology and multivariate analysis Section 1: Number 3: Stephen M. Evans & Jens Randel Nyengaard: Introduction 4: Daniel A. Peterson: The use of fluorescent probes in cell counting procedures 5: Bente Finsen, R. Gregersen, E. Lehrmann, S. Lovmand & M.J. West: Counting in situ hybridized neurons 6: Jens Randel Nyengaard, K-A. Dorph-Petersen, Y. Tang: Number in electron microscopy: estimation of total number of synapses in the main regions of human neocortex 7: Annemette Lokkegaard: The number of microvessels estimated by an unbiased stereological method applied in a brain region Section 2: Volume 8: Stephen M. Evans & Jens Randel Nyengaard: Introduction 9: Trine Tandrup: The nucleator and the planar and optical rotators applied in rat dorsal root ganglia 10: Karl-Anton Dorph-Petersen, Raben Rosenberg & Jens Randel Nyengaard: Estimation of number and volume of immunohistochemically stained neurons in complex brain regions Section 3: Length 11: Stephen M. Evans & Jens Randel Nyengaard: Introduction 12: Yong Tang & Jens Randel Nyengaard: Length estimation of nerve fibers in human white matter using isotropic uniformly random sections 13: Jytte Overgaard Larsen, M. von Euler & Ann Marie Janson: Virtual test systems for estimation of orientation- dependent parameters in thick, arbitrary oriented sections exemplified by length quantification of regenerating axons in spinal cord lesions using isotropic, virtual planes Section 4: Second order stereology 14: Stephen M. Evans: Spatial distribution Section 5: Cell Culture 15: Hannsjorg Schroder, Jens Rendel Nyengaard, W. Selberis, E. Lain, A. Keller, C. Kohler and B. Witter: Unbiased morphometrical techniques for the quantitative assessment of cells in primary dissociation cultures

ISBN: 9780198505280
ISBN-10: 0198505280
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 350
Published: 1st August 2004
Publisher: Oxford University Press
Country of Publication: GB
Dimensions (cm): 23.7 x 16.4  x 2.5
Weight (kg): 0.72