Contributors vii
Foreword x
Preface xii
Steve Kitchen John D. Olson & F. Eric Preston
Part 1: General Quality Program
1 General quality planning in the hemostasis laboratory 3
John D. Olson
2 Hemostasis test validation performance and reference intervals: international recommendations and guidelines 12
RichardA.Marlar
3 Causes of errors in medical laboratories 22
Giuseppe Lippi & Emmanuel J. Favaloro
4 International standards in hemostasis 32
Trevor W. Barrowcliffe & Anthony R. Hubbard
5 Sample integrity and preanalytical variables 45
Dorothy (Adcock) Funk
6 Internal quality control in the hemostasis laboratory 57
Steve Kitchen F. Eric Preston & John D. Olson
7 External quality assessment in hemostasis: its importance and significance 65
F. Eric Preston Steve Kitchen & Alok Srivastava
8 The unique challenges of hemostatic testing in children 77
M. Patricia Massicotte Mary E. Bauman Vanessa Chan & Anthony K.C. Chan
Part 2: Quality in Coagulation Testing
9 Initial evaluation of hemostasis: reagent and method selection 95
Wayne L. Chandler
10 Assay of factor VIII and other clotting factors 105
Steve Kitchen & F. Eric Preston
11 Application of molecular genetics to the investigation of inherited bleeding disorders 115
Stefan Lethagen Morten Duno & Lars Bo Nielsen
12 Detecting and quantifying acquired functional inhibitors in hemostasis 124
Bert Verbruggen Myriam Dardikh & Britta Laros-van Gorkom
13 Standardization of d-dimer testing 136
Guido Reber & Philippe de Moerloose
14 Point-of-care testing in hemostasis 147
Chris Gardiner Dianne Kitchen Samuel Machin & Ian Mackie
Part 3: Quality in Testing for Platelet Function and von Willebrand Disease
15 Diagnostic assessment of platelet function 159
Paquita Nurden Alan Nurden & Martine Jandrot-Perrus
16 Laboratory evaluation of heparin-induced thrombocytopenia 174
Theodore (Ted) E. Warkentin & Jane C. Moore
17 Laboratory evaluation of von Willebrand disease: phenotypic analysis 192
Emmanuel J. Favaloro
18 Laboratory analysis of von Willebrand disease: molecular analysis 204
Anne C. Goodeve & Ian R. Peake
Part 4: Quality in Thrombophilia Testing and Monitoring Anticoagulation
19 Quality issues in heritable thrombophilia testing 219
Isobel D. Walker & Ian Jennings
20 Evaluation of antiphospholipid antibodies 233
Michael Greaves
21 Monitoring heparin therapy 244
Marilyn Johnston
22 Monitoring oral anticoagulant therapy with vitamin K antagonists 253
Armando Tripodi
23 Monitoring new anticoagulants 264
Elaine Gray & Trevor W. Barrowcliffe
Index 273