Purine and Pyrimidine Metabolism in Man VII

Biochemical Approach to New Medications.- Antimetabolites in Cancer Chemotherapy.- 2-Chlorodeoxyadenosine Chemotherapy Triggers Programmed Cell Death in Normal and Malignant Lymphocytes.- ICI D1694, an Inhibitor of Thymidylate Synthase for Clinical Study.- Action and Sequence Dependent Interaction of Acivicin and 6-Thioguanine in the Human Derived Maligant T-ALL and CALLA+ Cell Lines.- Conversion of Acyclic Nucleoside Phosphonates to their Diphosphate Derivatives by 5-Phosphoribosyl-1-Pyrophosphate (PRPP) Synthetase.- Derivation of New Drugs for Therapy of AIDS.- Biochemical and Pharmacological Properties of C1-972, a Novel 9-Deazaguanine Analog Purine Nucleoside Phosphorylase (PNP) Inhibitor.- Pyrrolo[3,2-D]pyrimidines, a New Class of Purine Nucleoside Phosphyorylase (PNP) Inhibitors as Potential T-cell Selective Immunosuppressive Agents.- Modulation of Metabolism and Anti-HIV-1 Activity of Purine 2?,3?-Dideoxynucleosides by IMP Dehydrogenase Inhibitors.- Acadesine (AICA Riboside) Inhibits Platelet Aggregation in Human Whole Blood.- Concentration and Time Dependent Growth Inhibition and Metabolism in Vitro by 2?, 2?-Difluoro-deoyxcytidine (Gemcitabine).- Thiopurine Methyltransferase Activity and Efficacy of Azathioprine Immunosuppresion in Transplant Recipients.- Increase in 2?,5?-Oligoadenylate Synthetase Caused by Deoxycoformycin in Hairy Cell Leukaemia.- A Dual Anti-Tumour Effect of a Combination of Interferon-? and 5-Fluorouracil or 2-Chlorodeoxyadenosine on Natural Killer (NK) Cell Mediated Cytotoxicity.- The Effect of Methotrexate on the Folate Coenzyme Pools in Human Hepatoma Cells in Culture.- Purine Nucleotide Biosynthesis in Leukemic Promyelocytes Treated with Retinoids.- 6-Mercaptopurine Metabolism in Two Leukemic Cell Lines.- Synergistic Interaction of Methotrexate and 6-Mercaptopurine in Human Derived Malignant T-and CALLA+ Cell Lines.- 6-Thioguanine Metabolism in Human Erythrocytes.- The Impact of Selected Nucleosides on the Cytotoxicity of ARA-C in HL60 Cells.- Effect of Chloroadenosine on the Phosphoinosotide Turnover in Human T Lymphoblasts Activated through the T-cell Receptor/CD3 Complex.- Isolated Liver Perfusion versus Hepatic Artery Infusion with 5-Fluorouracil in a Rat Model; Effects on Thymidylate Synthase.- Changes of Purine Nucleotide Metabolism of Ehrlich Ascites Cells during the Transition of Tumour Growth.- Purine Nucleotides, Nucleosides and Nucleobases of Liver, Skeletal Muscle, Blood and Tumour Cells during the Growth of Ehrlich Ascites Tumour in Mice.- Uridine Fluxes in Healthy Proliferating T-Lymphocytes, MOLT-3 T-ALL Cell-Line Cells and Differentiated MOLT-3 Cells.- Some Aspects of Purine Nucleotide Metabolism in Human Lymphocytes: Nucleotide Content in Human Lymphoblastoid Lines, Transfected with HIV.- Metabolism and Action of 2?, 2?-Difluoro-deoxycytidine: Self Potentiation of Cytotoxicity.- Effect of Leucovorin on 5-Fluorouracil Induced Inhibition of Thymidylate Synthase in Patients with Colon Cancer.- A Novel Xanthine Dehydrogenase Inhibitor (BOF-4272).- Changes Caused by Ethanol Intake on Metabolism of Hypouricemic Agents (Combination of Allopurinol and Benzobromarone).- Allopurinol in Breast Milk.- Pharmacokinetics of Benzbromarone: Evidence for a Biliary-Intestinal Biliary-Recirculation.- Analysis of Uric Acid Transport in Renal Tubules Using Benzbromarone and Pyrazinamide.- Deficient Benzbromarone Elimination from Plasma: Evidence for a New Genetically Determined Polymorphism with an Autosomal Inheritance.- Nucleotide Status in Erythrocytes of Rats Infected with Plasmodium berghei.- Hypoxanthine Depletion Induced by Xanthine Oxidase Inhibits Malaria Parasite Growth in Vitro.- New Nucleoside Transport Pathways Induced in the Host Erythrocyte Membrane of Malaria and Babesia Infected Cells.- Effect of Polyethylene Glycol-Modfied Adenosine Deaminase (PEG-ADA) Therapy in Two ADA-Deficient Children: Measurement of Erythrocyte Deoxyadenosine Triphosphate as a Useful Tool.- Urate Transport in the Proximal Tubule of Human Kidney.- The Genetics of Renal Excretion of Urate in Man.- What is the Pathogenesis of Familial Juvenile Gouty Nephropathy?.- Renal Urate Hypoexcretion Preceding Renal Disease in a New Kindred with Familial Gouty Nephropathy (FJGN).- Familial Nephropathy and Gout: Which Comes First?.- Does Allopurinol Affect the Progression in Familial Juvenile Gouty Nephropathy?.- Congenital Chloride Losing Enteropathy Associated with Tophaceous Gouty Arthritis.- The Role of Lead in Gout Nephropathy Reviewed: Pathogpenic or Associated Factor?.- Myogenic Hyperuricemia in Hypoparathyroidism.- Lipoprotein Metabolism in Primary Gout Influence of Alcohol Intake and Body Weight.- Serum Urate and Uric Acid Excretion.- Gout and Main Rheumatic Diseases in Man.- Importance of Confounding Factors Age and Sex in the Correlation of Serum Uric Acid, Cholesterol and Triglyceride Levels.- Changes in Urate Metabolism after Castration of Patients Suffering from Carcinoma of the Prostate.- Renal Hypouricemia Associated with Hyperoxypurinemia due to Decreased Renal Excretion of Oxypurines: A New Defect in Renal Purine Transport.- Significance of Hypouricemia.- Organic Distribution and Interrelationships of Lesions Occuring in Laying Hens Suffering from Gout and Urolithiasis.- Biochemical Investigations on Chicken Gout Observed in the Marmara Region in Turkey.- Production of Uric Acid and Allantoin in Perfused Rat Liver.- Dynamics in the Purine Nucleotides of Liver during Various Periods of Hypoxia/Ischaemia and Reoxygenation.- Adenosine Origin and Clinical Roles.- Oxypurines in Extracellular Fluids from Piglets during Hypoxemia and Reoxygenation.- Regulation of Adenosine Concentrations by Acadesine (AICA-Riboside) in Human B-Lymphoblasts.- Preservation of Adenine Nucleotides following Ischemia and Reperfusion: Correlation with Functional Recovery.- An Alternative Pathway of Adenylate and ATP Synthesis.- Preservation of Nucleotide Pool during Heart Transplantation and Evaluation of Adenylate Catabolic Pathways in the Human Heart.- The Influence of Acetate on Adenine Nucleotides in Rat Liver.- Purine Nucleotide Catabolism in Rat Liver after Castration.- Adenine Nucleotide Metabolism in Liver Ischemia: Effect of Allopurinol.- Effect of Pulsed Electromagnetic Fields on the Adenine Nucleotide Pool and Energy Charge in Cells in Culture.- Mechanism Accounting for Changes of Adenine Nucleotide Content in Mitochondria at Ischemia.- New Aspects of Purine Nucleotide Metabolism: Formation of ADP from Inorganic Phosphate during Degradation of AMP.- Phosphorylation of Adenosine by an Exchange Reaction between AMP and Adenosine in Anoxic Hepatocytes.- Hypoxanthine and Inosine Metabolism in Cultured Rat Cardicmyocytes.- The Mechanism of Conversion of Xanthine Dehydrogenase to Oxidase and the Role of the Enzyme in Reperfusion Injury.- Purification of Xanthine Oxidase from Human Milk.- Mechanisms of Protection of Hepatocytes at Anoxia and Rejoxygenation by the Xanthine Oxidase Inhibitor Oxypurinol.- Oxypurinol Reduced Ischaemic Brain Injury in the Gerbil and Rat.- Acadesine (AICA Riboside) Attenuates Reperfusion Injury and Oxidant-Induced Damage of the Heart.- Effects of H2O2 and CHPO on ATP, CP Content and 14 C-HX Uptake by HUVECS.- Absence of Xanthine Oxidoreductase Activity in Human Myocardium.- Lower Xanthine Oxidoreducatase Activity in Isolated Perfused Hearts if Xanthine Replaces Hypoxanthine as Substrate.- Evidence from in Vitro Studies that Dihydroorotate Dehydrogenase May Be a Source of Toxic Oxygen Species.- Influence of Oxipurinol on Colitis Induced in Rat Colon by Trinitrobenzensulfonic Acid Treatment.- A Xanthinuric Family - the Proposita having Immunologically Reactive Xanthine Oxidase but no Xanthine Oxidase Activity.- Human Hepatic Peroxisomes with Crystalloid Cores Associated with Urate Oxidase Activity.- Structural Analysis of the Rat Uricase Gene and Evidence that Lysine 164 Is Involved in the Substrates-Binding Site of the Enyzme.- Study of DNA Repair in Peripheral Blood Lymphocytes of Patients with Rheumatic Diseases Undergoing Treatment.- Nucleoside Transport in Lymphocytes from Alcoholics and Non-Alcoholics.- Initial Rate Measurements of Cellular Nucleoside Transport: Time Course, Initial Curvature of Time Curves and Metabolism.- Relationships between Metabolic Enzymes and the Nucleoside Transport.- Active Transport of Adenosine into Primary Cultures of Brain Cells and its Methodological Consequences.- Intestinal Transport and Metabolism of Purine and Pyrimidine Nucleosides.- Guanine Uptake by Human Erythrocytes.- Radioligand Binding Studies on the Nucleoside Transport Protein.- Nucleoside Transport in Guinea-Pig Myocardium.- Comparison of the Existing Nucleoside Transport Inhibitors: in Vitro and in Vivo.- Effect of Membrane Lipid Composition on the Functional Activity of a Reconstituted Nucleoside Transporter Derived from Ehrlich Ascites Cells.- Antibodies and Proteases as Probes of the Structures of Mammalian Nucleoside Transporters.- Expression of Sodium Dependent-Nucleoside Transporters in Xenopus Oocytes.- Control of Nucleoside Transport in Neural Cells. Effect of Protein Kinase C Activation.- Isolation of Nucleoside Permeases from Escherichia coli.- Murine Erythroleukemia Cells and Resistant to Periodate-Oxidised Adenosine have Lowered Levels of Nucleoside Transporter.- Effect of Ischemia on Cardiac Adenosine Binding Sites.- A Ferritin-Cyclohexyladenosine Probe for Electron Microscopical Localization of A1 Adenosine Receptor.- Effect of Adenosine on the Membrane Potential Changes of Human Neutrophils Triggered by the Tripeptide F-Met-Leu-Phe.- A2 Adenosine Receptors in Neutrophils from Healthy Volunteers and Patients with Rheumatic Disease.