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Proteolysis in Cell Functions : Biomedical and Health Research - V.K.Hopsu- Havu

Proteolysis in Cell Functions

Biomedical and Health Research

By: V.K.Hopsu- Havu (Editor), M. Jarvinen (Editor), Heidrun Kirschke (Editor)

Hardcover Published: 1st January 1997
ISBN: 9789051993226
Number Of Pages: 592

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The proteolytic enzymes have an essential function in all cells. Their activities are regulated by the rate of synthesis, activation of proenzymes and by the rate of synthesis of their inhibitors. They are synthesized in ribosomes like any other proteins and transported to various storage organelles or secreted from the cells and are activated in the pericellular space or in interstitium. Various cells and tissues have their characteristic enzyme patterns which serve their specific functions. Proteolytic enzymes take part and often have a regulatory role in numerous phases of cell function, e.g. cell division, migration, apoptotic as well as necrotic cell death etc. Diseases in which proteolysis has been subject of active research are e.g. cancer metastasis, viral infections, e.g. HIV, and Alzheimer's disease. They are also an essential part in any tissue remodelling, wound healing, throughout the kingdom of fauna and flora.

Evolution and the Structural Classification of Peptidasesp. 3
Classification of Peptidases by Comparisons of Primary and Tertiary Structuresp. 13
Development and Validation of Homology Models of the Cathepsins H, L and Sp. 22
Phosphorylation of Proteasome and 26S Proteinase Subunitsp. 28
Production and Characterization of Monoclonal Antibodies Specific to Regulatory Subunits of 26S Proteasomep. 34
In Vitro and in Vivo Degradation of c-jun and c-fos Proteins by the Ubiquitous Calpains and by the Proteasomep. 38
Ubiquitin-Mediated Proteolysis and the Molecular Chaperone Hsc 70p. 47
Possible Roles of N-Linked Oligosaccharides on Cathepsin Ep. 55
Structure Studies on the Carbohydrate Moiety of Rat Liver Cathepsin Lp. 61
A Skeletal Muscle-Specific Calpain, p94, Exists in Myofibrils Bound to Connectin/Titinp. 68
Structural Characterization of Pathogenic Cysteine Proteinases from the Oral Bacterium Porphyromonas Gingivalisp. 76
Initiating and Responsible Enzyme of Somatostatin Degradation in Human Placentap. 81
Aminopeptidase PS: a Widely Distributed Cytosolic Peptidasep. 88
Membrane-type-1 Matrix Metalloproteinase and Gelatinase A Activationp. 96
Characteristics and Application of Cryotin, a Mixture of Psychrophilic Marine Proteinasesp. 104
Conformation of the DE-Loop is Crucial for Proteolytic Degradation of Photosystem II Reaction Centre Protein D1p. 112
Manipulating the Autolytic Pathway of a Bacillus Proteasep. 120
Regulation of Cysteine Proteinase Activity by Protein Inhibitors, Zymogen Activation and pHp. 128
Peptide Inhibitors of Cathepsin C Designed through the Use of Combinatorial Librariesp. 137
Expression and Characterization of Hirustasin from Saccharomyces Cerevisiaep. 141
Production of Chimeric Cystatins by Artificial Exon Shuffling and Partial Characterization of the Chimerasp. 149
Human Cystatin A is Inactivated by Truncation of Carboxyl-Terminal Regionp. 158
The Propeptide of Human Cathepsin S is a Powerful and Specific Inhibitor of Cathepsin S Activityp. 167
Inhibition of Matrix Metalloproteinases by Long Chain Trans-Unsaturated Fatty Acidsp. 174
The Activity of Cysteine Proteinases in Nonaqueous Environments and its Potential for Industrial Applicationsp. 179
Genomic Structures of the Protease Domain of Mouse Meprin [alpha] and [beta] Subunitsp. 187
The Transmembrane Domain of the [alpha]-Subunit of Paba-Peptide Hydrolase (Human Meprin) is Involved in its ER-Retentionp. 196
Analysis of the Genes of Thimet Oligopeptidase (EP 24.15) and Oligopeptidase M (EP 24.16) and Intracellular Targeting of EP 24.16 by Alternative Promoter Usagep. 208
Biosynthesis and Trafficking of Cathepsin Ep. 215
Synthesis and Processing of the Monomeric and Dimeric Forms of Human Cathepsin E Expressed in Chinese Hamster Ovary Cellsp. 223
Trafficking and Processing of Cathepsin Dp. 229
The Respective Role of Mannose-6-Phosphate Residues and of Prosaposin in the Segregation of Lysosomal Procathepsin Dp. 234
Expression and Trafficking of Lysosomal Procathepsin D in Human Colon Cancer HT-29 Cells are Influenced by the State of Enterocytic Differentiationp. 242
Oligopeptidase M (Neurolysin). Targeting to Mitochondria and Cystosol in Rat Tissuesp. 248
Crystallization and Preliminary X-ray Analysis of a Soluble, Catalytically Active Form of Escherichia coli Type 1 Signal Peptidasep. 256
Investigating the Structural and Chemical Flexibility of the Essential Lysine in Escherichia Coli Type 1 Signal Peptidase by the Use of Site-directed Chemical Modificationp. 262
Type 1 Signal Peptidases of Bacillus subtilisp. 268
Role of the Thylakoidal Processing Peptidase in Chloroplast Protein Importp. 276
A Microbody Protease from Castor Bean Endosperm Processes Glyoxysomal Precursor Proteinsp. 284
Potato Mitochondrial Processing Peptidase Complexp. 290
Membrane-associated ATP-dependent Degradation of Mitochondrial Precursor Proteinsp. 298
Mitochondrial Processing Peptidase Integrated into the bc[subscript 1] Complex of the Respiratory Chain in Spinachp. 307
Effect of Molecular Chaperones on Proteolytic Processing of Mitochondrial Precursor Proteinsp. 314
Degradation of Membrane Proteins by AAA Proteases in Mitochondriap. 323
Recognition of the Precursor Proteins by the Mitochondrial Processing Peptidasep. 332
Mitochondrial Intermediate Peptidase: Natural Substrates and Biologic Rolep. 340
The Mitochondrial Inner Membrane Peptidase of Yeast and Genes Affecting its Functionp. 348
Regulation of Autophagy by Protein Phosphorylationp. 357
Autolysosome Membrane Proteins: Witness to Ongoing Autophagic Processp. 367
Autophagic Sequestration: A New Function for Trimeric G Proteins?p. 374
Mechanisms of Autophagic Proteolysis in Permeabilized Hepatocytes. Involvement of GTP-binding Proteins at Multiple Stepsp. 381
The Regulation and Specificity of Autophagic Lysosomal Proteolysisp. 388
Lysosomal Degradation of Peroxisomes in the Yeast, Pichia pastorisp. 394
A Lysosomal Pathway for the Selective Degradation of Cytosolic Proteins in Rat Liverp. 402
Proteasome Inhibitors Block Germinal Vesicle Breakdown in Starfish Oocytesp. 411
Activation of the Proteasome in Embryonic Cell Cyclep. 418
Dipeptidyl Peptidase IV in C6 Rat Glioma Cell Line Differentiationp. 423
Localization of Cathepsins B, H, L, K and S and Cystatins A and B in Developing Mouse Skeletal Tissuesp. 431
Epidermal Serine Protease Inhibitors Regulate Human Corneocyte Cell Sheddingp. 438
Induction of Differentiation and/or Apoptosis by Proteasome Inhibitionp. 447
Cathepsin B in Invasive Tumorsp. 455
Expression of an Alternative Spliced Form of Cathepsin B from Human Tumorsp. 463
Cathepsin B and Cathepsin L: Prognostic Factors in Human Lung Cancer?p. 472
Overexpression of Cathepsins B, H, L and S in Malignant Tumors of the Lymph Nodep. 479
Regulation of Matrix Metalloproteinases by Human Tumor-Associated Trypsin(ogen)-2p. 485
Plasminogen Activators and Collagenases in Fibroblasts Sequentially Immortalized by the Polyomavirus LT-Gene and Transformed by the E7 and E6-E7 Human Papillomavirus Genesp. 494
Biological Effects of Ras and Cystatin [alpha] in Mouse Fibroblastsp. 500
Proteases Involved in the Processing of the Alzheimer's Disease Amyloid Precursor Proteinp. 507
Regulation of Proteolysis of Alzheimer's Disease Amyloid Precursor Protein by Intracellular Signal Transduction Pathwaysp. 513
Cleavage of Cellular Proteins by the HIV-1 Proteasep. 520
Molecular Cloning and Characterization of Putative Digestive Cysteine Proteinases in Insects as Probable Target Enzymes of Phytocystatinsp. 524
Antibacterial Activity against Porphyromonas Gingivalis by Cystatinsp. 532
Cysteine Proteinase Inhibitors as a Model of Lysosomal Storage Diseasep. 540
Protease Inhibitors and A Pulmonary Surfactant in Airway Fluid are Potential Defensive Compounds against Infection by Influenza A and Sendai Virusesp. 545
[alpha]-1-Antichymotrypsin Variants, ACT Isehara-1 and ACT Isehara-2p. 555
The Use of Proteinase Propeptides as Selective Inhibitors of Pest Digestive Enzymesp. 562
Subject Indexp. 567
Author Indexp. 573
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9789051993226
ISBN-10: 9051993226
Series: Biomedical and Health Research
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 592
Published: 1st January 1997
Publisher: IOS Press
Country of Publication: US
Dimensions (cm): 23.4 x 15.6  x 3.1
Weight (kg): 1.0
Edition Number: 1

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