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Protein Pharmacokinetics and Metabolism : NATO Asi Series - Bobbe L. Ferraiolo

Protein Pharmacokinetics and Metabolism

NATO Asi Series

By: Bobbe L. Ferraiolo (Editor), Marjorie A. Mohler (Editor), Carol A. Gloff (Editor)

Hardcover Published: 30th November 1992
ISBN: 9780306441516
Number Of Pages: 276

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Investigation of the pharmacokinetics and metabolism of human proteins has escalated over the last two decades because of the use of recombinant human proteins as therapeutic agents. In addition, the development and improvement of analytical techniques enabling the detection of minute quantities of proteins in biological matrices have aided this process. In assembling this volume, we sought to provide a state-of-the-art as­ sessment of the pharmacokinetics and metabolism of protein therapeutics through complete reviews of selected examples. A comprehensive review of all protein therapeutics was not attempted; the majority -of the therapeutic protein classes and crucial scientific issues have been addressed, however. Therefore, we are confident that this volume will provide a useful reference for scientists in this field. The volume has been divided into two general parts. The first part (Chapters 1-3) is composed of general reviews of topics of importance in pharmacokinetic/metabolism studies of proteins: goals and analytical meth­ odologies, effects of binding proteins, and effects of antibody induction, respectively. The second part (Chapters 4-8) consists of specific, detailed reviews by therapeutic protein class: growth factors and hormones, cyto­ kines, cardiovascular proteins, hematopoietic proteins, and antibodies, respectively. The editors are grateful to the contributors for the patience, personal sacrifice and perseverance required to complete this volume. BoDDE L. FERRAIOLO MARJORIE A. MOHLER CAROL A. GLOFF ix Contents Chapter 1 Goals and Analytical Methodologies for Protein Disposition Studies Bobbe L. Ferraiolo and Marjorie A. Mohler 1. Introduction ................................................. .

Goals and Analytical Methodologies for Protein Disposition Studies
Binding Proteins of Protein Therapeutics
Potential Effects of Antibody Induction by Protein Drugs
Pharmacokinetics and Metabolism of Protein Hormones
Pharmacokinetics and Metabolism of Therapeutic Cytokines
Pharmacokinetics and Metabolism of Cardiovascular Therapeutic Proteins
Pharmacokinetics and Metabolism of Hematopoietic Proteins
Pharmacokinetics and Metabolism of Therapeutic and Diagnostic Antibodies
Index
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780306441516
ISBN-10: 0306441519
Series: NATO Asi Series
Audience: General
Format: Hardcover
Language: English
Number Of Pages: 276
Published: 30th November 1992
Publisher: Springer Science+Business Media
Country of Publication: US
Dimensions (cm): 24.08 x 15.9  x 2.16
Weight (kg): 0.55

Earn 678 Qantas Points
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