The role of metal ions in protein folding and structure is a critical topic to a range of scientists in numerous fields, particularly those working in structural biology and bioinorganic chemistry, those studying protein folding and disease, and those involved in the molecular and cellular aspects of metals in biological systems. Protein Folding and Metal Ions: Mechanisms, Biology and Disease presents the contributions of a cadre of international experts who offer a comprehensive exploration of this timely subject at the forefront of current research.
Divided into four sections, this volume:
- Provides case study examples of protein folding and stability studies in particular systems or proteins that comprise different metal ions of co-factors
- Reviews the proteins that shuttle metal ions in the cell to a particular target metalloprotein
- Illustrates how metal binding can be connected to pathological protein conformations in unrelated diseases, from cancer to protein deposition disorders such as Parkinson's disease
- Addresses protein redesign of metal-containing proteins by computational methods, folding simulation studies, and work on model peptides - dissecting the relative energetic contribution of metals sites to protein folding and stability
Together, the 13 chapters in this text cogently describe the state of the science today, illuminate current challenges, propose future possibilities, and encourage further study in this area that offers much promise especially with regard to novel approaches to the treatment of some of the most challenging and tragic diseases.
FOLDING AND STABILITY OF METALLOPROTEINS Metal Ions, Protein Folding, and Conformational States: An Introduction, Claudio M. Gomes and Pernilla Wittung-Stafshede The Folding Mechanism of c-Type Cytochromes, Carlo Travaglini-Allocatelli, Stefano Gianni, and Maurizio Brunori The Mechanism of Cytochrome c Folding: Early Events and Kinetic Intermediates, Eefei Chen, Robert A. Goldbeck, and David S. Kliger Stability and Folding of Copper-Binding Proteins, Irina Pozdnyakova and Pernilla Wittung-Stafshede Iron-Sulfur Clusters, Protein Folds, and Ferredoxin Stability, Sonia S. Leal and Claudio M. Gomes Folding and Stability of Myoglobins and Hemoglobins, David S. Culbertson and John S. Olson MECHANISMS OF METAL TRANSPORTERS, AND ASSEMBLY Frataxin: An Unusual Metal-Binding Protein in Search of a Function, Annalisa Pastore Mechanism of Human Copper Transporter Wilson's Disease Protein, Amanda Barry, Zara Akram, and Svetlana Lutsenko METAL IONS, PROTEIN CONFORMATION, AND DISEASE I -Synuclein and Metals, Aaron Santner and Vladimir N. Uversky Zinc and Misfolding, James S. Butler and Stewart N. Loh The Octarepeat Domain of the Prion Protein and Its Role in Metal Ion Coordination and Disease, Glenn L. Millhauser METALLOPROTEIN DESIGN, SIMULATION, AND MODELS Metallopeptides as Tools to Understand Metalloprotein Folding and Stability, Brian R. Gibney The Folding Landscapes of Metalloproteins, Patrick Weinkam and Peter G. Wolynes
Tertiary; University or College
Number Of Pages: 308
Published: 5th October 2010
Publisher: Taylor & Francis Inc
Country of Publication: US
Dimensions (cm): 23.5 x 15.6
Weight (kg): 0.61
Edition Number: 1