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Progress in Nucleic Acid Research and Molecular Biology Volume  75 : Volume 75 - Kivie Moldave

Progress in Nucleic Acid Research and Molecular Biology Volume 75

Volume 75

Hardcover

Published: 10th October 2003
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Nucleic acids are the fundamental building blocks of DNA and RNA and are found in virtually every living cell. Molecular biology is a branch of science that studies the physicochemical properties of molecules in a cell, including nucleic acids, proteins, and enzymes. Increased understanding of nucleic acids and their role in molecular biology will further many of the biological sciences including genetics, biochemistry, and cell biology. Progress in Nucleic Acid Research and Molecular Biology is intended to bring to light the most recent advances in these overlapping disciplines with a timely compilation of reviews comprising each volume.
* Provides a forum for discussion of new discoveries, approaches and ideas in molecular biology
* Includes contributions from the leaders in the field
* Has abundant references

Some Articles Planned for Future Volumesp. ix
Molecular Regulation, Evolutionary, and Functional Adaptations Associated with C to U Editing of Mammalian ApolipoproteinB mRNAp. 1
RNA Editing: General Overview of Underlying Biochemical Mechanisms and Evolutionary Developmentp. 2
C to U RNA Editingp. 5
C to U ApoB RNA Editing: cis-Acting Elementsp. 14
C to U ApoB RNA Editing: trans-Acting Factorsp. 17
Summaryp. 33
Acknowledgmentsp. 33
Referencesp. 33
Polymorphisms in the Genes Encoding Members of the Tristetraprolin Family of Human Tandem CCCH Zinc Finger Proteinsp. 43
Introductionp. 44
Materials and Methodsp. 45
Resultsp. 52
Discussionp. 63
Acknowledgmentsp. 66
Referencesp. 66
Molecular and Cell Biology of Phosphatidylserine and Phosphatidylethanolamine Metabolismp. 69
Membrane Phospholipidsp. 70
Pathways for Biosynthesis of Phosphatidylserine and Phosphatidylethanolaminep. 71
Enzymes of Phosphatidylserine Biosynthesisp. 74
Enzymes of Phosphatidylethanolamine Biosynthesisp. 82
Regulation of PS and PE Biosynthesisp. 85
Interorganelle Transport of PS and PEp. 87
Intramembrane Transport of PS and PEp. 92
Biological Functions of PS and PEp. 95
Future Directionsp. 97
Referencesp. 98
DNA-Protein Interactions during the Initiation and Termination of Plasmid pT181 Rolling-Circle Replicationp. 113
Introductionp. 114
Origins of Replication of the Plasmids of the pT181 Familyp. 116
Initiator Proteins of the Plasmid pT181 Familyp. 122
Mechanism of Inactivation of the Plasmid pT181 Family Rep Proteinsp. 126
Role of Host Proteins in pT181 RC Replicationp. 129
Replication of the Lagging Strand of Plasmid pT181p. 132
Conclusions and Future Directionsp. 133
Acknowledgmentsp. 133
Referencesp. 133
Herpes Simplex Virus Type-1: A Model for Genome Transactionsp. 139
Introduction to Herpesviridaep. 140
HSV-1 Life Cycle, Genome Structure, and Replication Genesp. 140
Initiation of Replicationp. 144
Elongationp. 151
Interaction of the HSV-1 DNA Replication Machinery with DNA Damagep. 155
Homologous Recombinationp. 159
Concluding Remarksp. 163
Acknowledgmentsp. 165
Referencesp. 165
Enzymology and Molecular Biology of Glucocorticoid Metabolism in Humansp. 173
Introductionp. 174
Glucocorticoid Actionp. 175
The Free Hormone Hypothesisp. 177
Glucocorticoid Receptorsp. 178
Nongenomic Action of Glucocorticoidsp. 179
Glucocorticoid Resistancep. 180
11[beta]-Hydroxysteroid Dehydrogenase (11[beta]-HSD) as Prereceptor Controlp. 181
Hydroxysteroid Dehydrogenases: Physiological Rolep. 182
The History of Two Isoforms: 11[beta]-HSD Type 1 and 11[beta]-HSD Type 2p. 182
A (Patho)physiological Role for 11[beta]-HSD 1 and 11[beta]-HSD 2p. 183
11[beta]-HSD 2 and the Syndrome of "Apparent Mineralocorticoid Excess" (AME)p. 184
11[beta]-Hydroxysteroid Dehydrogenase Type 1 (11[beta]-HSD 1)p. 187
Conclusionsp. 203
Referencesp. 203
Dancing with Complement C4 and the RP-C4-CYP21-TNX (RCCX) Modules of the Major Histocompatibility Complexp. 217
Introductionp. 219
The Sophisticated Genetic Diversities of Human C4 and RCCX Modulesp. 221
Structural Diversities of the Human and Mouse C4 Proteinsp. 232
Nucleotide Polymorphisms in Human C4A and C4B Genesp. 245
Expression of C4A and C4B Transcripts and Proteinsp. 255
The Endogenous Retrovirus that Mediates the Dichotomous Size Variation of C4 Genesp. 260
Evolution of Complement C3/C4/C5 and the RCCX Modules in the MHCp. 267
Afterthoughts: Eleven Outstanding Issues to be Addressedp. 274
Acknowledgmentsp. 276
Referencesp. 276
The Roles and Regulation of Potassium in Bacteriap. 293
Paths of K[superscript +] Movementp. 296
Regulation of K[superscript +] Transport Systemsp. 305
K As An Intracellular Activatorp. 309
Regulation of Internal pH by K[superscript +]p. 311
Future Directionsp. 312
Referencesp. 313
Conformational Polymorphism of d(A-G)[subscript n] and Related Oligonucleotide Sequencesp. 321
Introductionp. 321
[alpha]-DNA Helix[left and right double arrow]Acid-Dependent Duplex Equilibriump. 323
Acid-Dependent Parallel Duplex[left and right double arrow]pH-Independent Parallel Duplex Equilibriump. 332
pH-Independent Parallel Duplex[left and right double arrow]Single-Hairpin Duplex[left and right double arrow]Two-Hairpin Tetraplex Equilibriap. 334
Concluding Remarksp. 342
Acknowledgmentsp. 344
Referencesp. 344
Indexp. 349
Table of Contents provided by Rittenhouse. All Rights Reserved.

ISBN: 9780125400756
ISBN-10: 0125400756
Series: Progress in Nucleic Acid Research and Molecular Biology : Book 75
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 356
Published: 10th October 2003
Publisher: Elsevier Science Publishing Co Inc
Country of Publication: US
Dimensions (cm): 22.9 x 15.2  x 1.27
Weight (kg): 0.63