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Progress in Medicinal Chemistry : Volume 42 - F D King

Progress in Medicinal Chemistry

Volume 42

Hardcover Published: 15th April 2004
ISBN: 9780444511430
Number Of Pages: 450

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This volume includes information on recent advances in five important areas: an account of inhibitors of the caspase family of proteolytic enzymes that represent a new class of anti-inflammatory and antiapoptotic agents of potential value in rheumatoid arthritis; and a survey of semi-synthetic and totally synthetic antibiotics and anti-HIV agents and their sites of interaction; the development of inhibitors of the intracellular enzyme acyl-CoA: cholesterol O-acyltransferase (ACAT) for the treatment of hypercholesterolemia; a description of recent progress in growth hormone secretagogues, with the focus on strategies to improve oral bioavailability and duration of action; and information on inhibition of the proteolytic enzyme, hepatitis C protease N-3(NS3), (required for vital replication) as one of the most attractive targets for HCV infections.

Preface
Human Ether-a-go-go Related Gene (Herg): A Chemist's Perspective
Fluorescence Based Assays
Selective and Combined Neurokinin Receptor Antagonists
Muscarinic Receptor Subtype Pharmacology and Physiology
The Transcription Factor NF-eB as Drug Target
Recent Advances in the Search for New Antimarial Agents
The Discovery of the CCR5 Receptor Antagonist UK-427857
A new agent for the Treatment of HIV infection and AIDS
Table of Contents provided by Publisher. All Rights Reserved.

ISBN: 9780444511430
ISBN-10: 0444511431
Series: Progress in Medicinal Chemistry : Book 42
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 450
Published: 15th April 2004
Publisher: Elsevier Science & Technology
Country of Publication: GB
Dimensions (cm): 21.59 x 14.73  x 2.29
Weight (kg): 0.69