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Progress in Human African Trypanosomiasis, Sleeping Sickness - Michael Dumas

Progress in Human African Trypanosomiasis, Sleeping Sickness

Paperback Published: July 1999
ISBN: 9782287596551
Number Of Pages: 346

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Human African Trypaniosomiasis (HAT) or sleeping sickness is an old disease to be now considered as reemergent. HAT is endemic in 36 sub-Saharan African countries, in areas where tsetse flies are found. The public health importance of HAT is underestimated, but the disease causes severe social disruption in many rural areas. Along the past fifteen years, numerous studies were made, and now, the mechanisms involved in the disease pathogenesis and in the characteristics of sleep-wake disruption become to be better understood. But, since 50 years, when current drugs were introduced, problems regarding HAT chemotherapy have not been solved. Nevertheless, in-depth studies about trypanosome metabolism have permitted to discover new drug targets. Written by specialists who are very experienced in their respective fields, the contributions provide an indispensable tool for practitioners and scientists.

"Trypanosomiasis exists when it is searched for ..."p. 1
Identification of trypanosomes: from morphology to molecular biologyp. 7
Antigenic variation in African trypanosomesp. 31
Carbohydrate metabolismp. 53
Polyamine metabolismp. 81
Cytokines and the blood-brain barrier in human and experimental African trypanosomiasisp. 105
Cytokines in the pathogenesis of human African trypanosomiasis: antagonistic roles of TNF-[alpha] and IL-10p. 119
Immunology of African trypanosomiasisp. 137
Pathology of African trypanosomiasisp. 157
Hormones in human African trypanosomiasisp. 183
Sleeping sickness: a disease of the clock with nitric oxide involvementp. 191
Electroencephalographic features and evoked potentials in human African trypanosomiasisp. 203
Clinical aspects of human African trypanosomiasisp. 215
Biological diagnosis of human African trypanosomiasisp. 235
Present strategies in the treatment of human African trypanosomiasisp. 253
The nitroimidazoles and human African trypanosomiasisp. 281
Experimental models for new chemotherapeutic approaches to human African trypanosomiasisp. 289
Prophylactic strategies in human African trypanosomiasisp. 301
International co-operation: past and presentp. 315
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9782287596551
ISBN-10: 2287596550
Audience: General
Format: Paperback
Language: English
Number Of Pages: 346
Published: July 1999
Publisher: Springer Editions
Country of Publication: FR
Dimensions (cm): 23.39 x 15.6  x 1.91
Weight (kg): 0.51