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Proceedings of the Ninth International Symposium on Cyclodextrins : Santiago de Compostela, Spain, May 31-June 3, 1998 - Juan Jose Torres Labandeira

Proceedings of the Ninth International Symposium on Cyclodextrins

Santiago de Compostela, Spain, May 31-June 3, 1998

Hardcover

Published: 31st August 1999
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This volume contains the proceedings of the Ninth International Symposium on Cyclodextrins, held in Santiago de Compostela, Spain, May 31 - June 3, 1998. The papers collected represent a summary of the last two years' achievements in the application of cyclodextrins in such diverse fields as pharmaceuticals, biotechnology, textiles, chromatography and environmental sciences.
Highlights: Chiral selection of chemicals, nuclear waste management, cyclodextrins in nasal drug delivery, cyclodextrins in pulmonary drug delivery, cyclodextrins as pharmaceutical excipients, pharmacokinetics, stabilization of drugs by cyclodextrins, structural characterization of cyclodextrin complexes by nuclear magnetic resonance and molecular modeling, artificial receptors, large cyclodextrins, cyclodextrins as enzyme models, new cyclodextrin derivatives and potentials.
Audience: This book will be of interest to researchers whose work involves biotechnology, pharmaceuticals, food and chemicals and chromatographic methods, as well as fundamental cyclodextrin research.

Preface: Welcome to Santiago de Compostelap. xvii
Acknowledgements and Sponsorsp. xviii
Separation and Characterization
Development of a fluorimetric-FIA method to monitor cyclodextrin production from starch and the formation of inclusion complexesp. 3
Development of enzyme immunoassays specific for natural [beta]- and [gamma]-cyclodextrins and synthetic derivatives. Pharmacokinetic analysis of cyclodextrins in ratp. 7
The role of host guest interaction in thickening and phase separation of [beta]-cyclodextrin polymer and polymers bearing cyclic hydrophobic side groupsp. 11
Specific binding and precipitation of [gamma]- cyclodextrin with monosaccharide in an aqueous solutionp. 15
Analysis of hydroxypropyl cyclodextrins by liquid chromatography and evaporative light scattering detectionp. 19
LC-ELSD or (and) LC-MS: a well suited technique for characterization of the differences in the commercially available DM-[beta]-CDSp. 23
Thermal degradation of cyclodextrinsp. 27
Cyclodextrin Derivatives
Selective modifications of cyclodextrinsp. 33
Cyclodextrin derivatives with enhanced solubilizing power and lower toxicityp. 37
[alpha]-Cycloaltrin: conformation and properties in the solid state and aqueous solutionp. 41
Symmetrical and non-symmetrical urea derivatives of [beta]-cyclodextrin and piperazine: application in capillary electrophoresisp. 49
Sulfated cyclodextrin derivativesp. 53
The molecular geometries of cyclofructinsp. 57
Molecular geometries of furanoid [beta] (1[right arrow] and [beta] (1[right arrow])-linked cyclogalactinsp. 63
Synthesis and characterization of peptido-cyclodextrins dedicated to drug targetingp. 69
Mono-6-tosyl-[beta]-cyclodextrin: preparation, hydrolysis and self-inclusion studies in aqueous solutionp. 73
Thiourea-bridged [beta]-cyclodextrin conjugatesp. 77
Associations of amphiphilic degradable polymers with [beta]-cyclodextrin polymers: pH - dependant networkp. 81
Original associating system between hydrophobically modified N, N-dimethylacrylamide hydroxyethyl methacrylate copolymers and water soluble [beta]-cyclodextrins polymersp. 85
Production of cyclomaltonaose ([delta]-cyclodextrin) by various cyclodextrin glycosyltransferasesp. 89
Capillary electrophoretic investigation of the inclusion complex forming properties of large cyclodextrinsp. 93
New sorbents containing [beta]-cyclodextrin: Synthesis, characterisation and, sorption propertiesp. 97
Preparation and characterization of sorbents containing [beta] CD derivatives coated or grafted onto silica gelp. 101
Comparative cation chelating properties of per (3,6 anhydro), -and per (3,6 anhydro-2-OMe) [alpha]-cyclodextrinsp. 105
Synthesis of cyclodextrin glycerol ethers and investigation of their binding propertiesp. 109
Conformational equilibria of [alpha]-cycloaltrin in solutionsp. 113
The synthesis of oligosaccharide-branched cyclodextrinsp. 117
Crystallization of partially O-alkylated [beta]-cyclodextrins by including polymersp. 121
Synthesis of per (2,3-di-o-hexanoyl)-[beta]-cyclodextrin and characterization of amphiphilic [beta]-cyclodextrin nanoparticlesp. 125
Thiamine-appended cyclodextrin dimer as a ligase modelp. 129
Substituted cyclodextrins with amino acids as hydrolysis enzyme modelsp. 133
Synthesis and molecular recognition abilities of modified [gamma]-cyclodextrins bearing two pyrene moietiesp. 137
Molecular "lego" composed of monosubstituted cyclodextrinsp. 141
Structural analyses of sugar branched cyclodextrin derivatives by the post-source decay fragment method in MALDI-TOF mass spectrometryp. 145
Three dimensional structure of branched [alpha]-cyclodextrins in solutionp. 149
Synthesis and enhanced chemiluminescence of new monocyclomaltooligosaccharide-bound 6-phenylimidazo[1,2-alpha]pyrazin-3(7H)-onesp. 153
Thermal behaviour and phase transitions of cyclomaltononaose([delta]-cyclodextrin)p. 157
Textile finishing with MCT-[beta]-cyclodextrinp. 161
Isolation, purification, and characterization of cyclomaltooctadecaose (v-CD) and cyclomaltononadecaose ([xi]-CD)p. 167
Supramolecular assembly of polycharged [beta]-cyclodextrin derivatives: Formation of heterodimers between a polyamino- and a polysulfonato-[beta]-cyclodextrinp. 171
Insoluble polymers with high amounts of [beta] CD: characterization and adsorption capacityp. 175
Influence of pH on the stability of the inclusion complex of methyl orange and [beta]-cyclodextrinp. 179
An improved synthesis of per(6-deoxyhalo) cyclodextrins using N-halo succinimides-triphenylphosphine in dimethylformamidep. 183
Cyclodextrins in Pharmacy and Biotechnology
Anti-asthmatic-cyclodextrin inclusion complex for pulmonary deliveryp. 189
Cyclodextrin-containing membranes. Synthesis and separation properties in pertractionp. 193
Efficacy and safety of cyclodextrins in nasal drug deliveryp. 197
A Preliminary study of a [beta]-cyclodextrin/salbutamol complex for possible use is a dry powder inhalerp. 203
Solubility of a isoxazolyl-naphtoquinone by complexation with hydropxypropyl-[beta]- cyclodextrinp. 207
A comparative study of the dissolution properties of piroxicam-[beta]-cyclodextrin inclusion complexes prepared by different methodsp. 211
A comparative pharmacokinetic study of intravenous solutions of miconazole with or without cyclodextrinsp. 215
Development of a sustained release dosage form containing a diclofenac-cyclodextrin inclusion complexp. 219
Influence of cyclodextrins on the solubility and the pharmacokinetics of albendazolep. 223
Evaluation of spironolactone bioavailability from solutions of [beta]-cyclodextrin derivatives in ratsp. 227
Chemosensors of modified cyclodextrins for detecting moleculesp. 231
Molecularly imprinted cyclodextrin polymers as artificial receptors - The requisites for remarkable imprintingp. 235
New developments in improvement og drug solubility and availability by cyclodextrinsp. 239
Design and evaluation of colon-specific drug delivery system based on cyclodextrin conjugatesp. 247
The effect of 2-hydroxypropyl-[beta]-cyclodextrin on the solubility, stability and brain targeting of chemical delivery systems for neuropeptidesp. 257
Enhanced complexation efficacy of cyclodextrinsp. 257
Coadministration of a water-soluble polymer increases the usefulness of cyclodextrins in solid oral dosage formsp. 261
Evaluation of degradation studies performed in aqueous cyclodextrin solutionsp. 265
The effect of cellulose ethers on indomethacin/cyclodextrin complexationp. 269
Physicochemical characterization and pharmacological properties of different cyclodextrin complexes of a platelet activating factor receptor antagonist: SR 27417Ap. 273
Mutual solubility enhancement by binary and multicomponent complexation of clomiphene and tamoxifenp. 277
Preparation and characterization of piroxicam alkali-salt-[gamma]-cyclodextrin complexesp. 281
Design and evaluation of a porosity-controlled osmotic pump tablet for chlorpromazine using (SBE)[subscript 7m]-[beta]-CDp. 285
Comparison of the solubilizing effect of ethyl carbonate of [gamma]-cyclodextrin to other cyclodextrin derivativesp. 289
Improved solubility and oral bioavailability of cyclosporin a by hydrophilic cyclodextrin complexationp. 293
Effect of amorphous [beta]-cyclodextrins on crystallization and polymorphic transition of tolbutamide in solid statep. 297
A new method for determination of stability constant of cyclodextrin complexes by membrane permeation techniquep. 301
Effects of hydrophilic cyclodextrins in aggregation of recombinant human growth hormonep. 305
Preparation and pharmaceutical evaluation of heptakis (2,6-di-O-methyl-3-O-acetyl)-[beta]-cyclodextrinp. 309
Characterization of itraconazole/2-hydroxypropyl-[beta]-cyclodextrin inclusion complex in aqueous solutionp. 313
Sustained release and intestinal absorption of drug from the hydrophobic [alpha]-, [beta]- and [gamma]-cyclodextrin complexp. 317
Hydroxypropyl gamma-cyclodextrin as a solubiliser and dissolution enhancing agent: the case of tolbutamide-a poorly water-soluble drugp. 321
Interactions of surfactants with tolbutamide-[beta]-cyclodextrin inclusion compound: the consequence in drug dissolutionp. 325
Differential scanning calorimetry as an analytical tool in determining the interaction between drug and cyclodextrinp. 329
Solubility enhancer decreases the dissolution of complexed drugs: effect of sodium-lauryl-sulfate on dissolution profile of complexed drugsp. 333
Interaction between ranitidine hydrochloride and [beta]-cyclodextrinp. 337
Physical and chemical changes in the properties of [beta]-cyclodextrin on inclusion complex formationp. 341
A new nonlinear method on determination of the stability constant for the steroid-cyclodextrin complexp. 343
2,4-Dichlorophenoxyacetic acid [alpha]- and [beta] CD inclusion complexes. A [superscript 1]H-nuclear magnetic resonance studyp. 347
Investigation of the inclusion complex and stoichiometry of omeprazole with [beta]-CD by [superscript 1]H-NMR spectroscopyp. 351
Influence of cyclodextrins on the chemical stability of salmon calcitonin in aqueous solutionp. 355
Complexation propierties of [beta]-cyclodextrin sulfobutylether sodium saltp. 359
How do cyclodextrins enhance drug permeability through biological membranes?p. 363
Differential scanning calorimetry analysis of crystallinity changes of naproxen in ground mixtures with maltohexaose. the non cyclic analog of alpha-cyclodextrinp. 367
Dissolution rate and thermal properties of naproxen in mixtures with amorphous or crystalline dimethyl [beta]-cyclodextrinp. 371
Improvement of econazole solubility in multicomponent systems with cyclodextrins and acidsp. 375
Phase-solubility analysis and molecular modeling in the study of naproxen-cyclodextrin interactionp. 379
Potency modification of antibacterial adamantane derivatives by compexation with [beta]-CD and HP-[beta]-CD. Study of their thermotropic properties in dipalmitoyl phosphatidylcholine bilayers containing cholesterol and [superscript 13]C NMR study of their structuresp. 383
Pharmacological investigations of new peptido-cyclodextrinsp. 387
Characterization of cyclodextrin complexes of (S)-naproxen by X-ray and thermal methods of analysisp. 391
CD-medium control of microbial sterol sidechain cleavagep. 395
Compressional properties of cyclodextrinsp. 399
In vitro and in vivo investigations of the specific binding of substance P-[gamma]-cyclodextrin adducts to rat brain NK1 receptorsp. 403
Stabilization of retinol with [gamma]-cyclodectrinp. 407
Inclusion study in [beta]-cyclodextrin and dimetyl-[beta]-cyclodextrin of antiparasitaries in solution and in the solid statep. 411
Study of inclusion compound of triamcinolone acetonidep. 415
Complexation of bile salts by [beta]-cyclodextrin and derivativep. 419
[superscript 1]HNMR contribution to prove the formation of inclusion complex between nimesulide and [beta]-cyclodextrin and its hydrophilic derivativesp. 423
Complexation of amino acids by 6[superscript A]-(hydroxyethylamino)-6[superscript A]-deoxy-[beta]-cyclodextrin ([beta]-CDea) and the Metallo-derivatives in Aqueous Solutionp. 427
Effect of the complexation of ciprofloxacin and norfloxacin with cyclodextrin derivatives on its dissolution characteristicsp. 433
Effect of hydroxypropyl-[beta]-cyclodextrin on the stability of pilocarpine in solution. Influence of the complex preparationp. 437
Dissolution behaviour of diclofenac sodium-[beta]- and hydroxypropyl-[beta]-cyclodextrin inclusion complexesp. 441
Effect of (SBE)[subscript 7m]-[beta]-CD on methylprednisolone transport across ethylcellulose microporous membranesp. 445
Optimization of entrapment of metronidazole in amphiphilic [beta]-cyclodextrin nanospheresp. 449
Cyclodextrin polysulfates in cell biology and therapeutic pharmacologyp. 453
The use of (SBE)[subscript 7m]-[beta]-CD (CAPISTOL) as a solubilizing and osmotic agent for controlled and complete oral delivery of poorly water soluble drugsp. 459
Preparation and characterization of inclusion complexes of cyclodextrins and tuberculosis primary treatment drugsp. 463
Influence of different cyclodextrins on physico-chemical and pharmacological properties of etodolacp. 467
Solid-state nifedipine-cyclodextrin photostability studiesp. 471
Inclusion complexation of nimesulide with [beta]-cyclodextrins and its formulation into tabletsp. 475
Inclusion complexation of tolfenamic acid with [beta]-cyclodextrins and its formulation into tabletsp. 479
Preparation by extrusion/spheronization of triamcinolone [beta]-cyclodextrin pellets as a fast release dosage formp. 483
Cyclodextrins in Chemistry
Renaturation of SDS- and thermally denaturated cellulase system by [alpha]-cyclodextrinp. 489
Absorption and recovery of volatile chlorinated hydrocarbons by use of aqueous solutions of branched cyclodextrinsp. 493
Oxidation of hydrophobic o-diphenols by lipoxygenase in the presence of cyclodextrinsp. 497
Inclusion properties, metal ion coordination ability and analytical applications of trehalose capped cyclodextrinsp. 501
Covalent and non-covalent adducts based on cyclodextrins and poly (ethyleneoxide)p. 505
The effect of cyclodextrins on the hydrolysis of benzyl halidesp. 509
Regioselective substitution of cyclodextrins without using protecting groupsp. 513
Molecular imprinting system using cyclodextrinp. 517
Energy transfer in naphthalene-containing rotaxane and polyrotaxanep. 521
Kinetic study of the oxidation of linoleic acid by soybean lipoxygenase in presence of [beta]-cyclodextrinp. 525
Esterolysis reaction catalysed by [beta]-cyclodextrin: influence of the tacticity of water-soluble polymersp. 529
Cyclodextrin assistance in the enzymatic degradation of the moringa glucosinolatep. 533
Kinetic effects on the dismutation of superoxide radical by copper (II) complexes of cyclodextrin-based SOD modelsp. 537
Cyclodextrins as molecular templatesp. 541
Cyclodextrin radicals produced by photochemical hydrogen abstraction by ketones and nitrogen heterocyclesp. 545
Oxidative stability of docosa hexaenoic acid oil (triglyceride form) included in cyclodextrinsp. 549
Molecular recognition of a self-assembled monolayer of a polydithiocarbamate derivative of [beta]-cyclodextrin on silverp. 553
Inhibition by cyclodextrins of nitrosation reactionsp. 557
Molecular necklaces containing reporter moleculesp. 563
Molecular dynamics simulations of polyrotaxanes formed by poly(oxytrimethylene) and [alpha]-cyclodextrinsp. 567
Kinetic behaviour of [beta]-cyclodextrins immobilized in PEEK-WC membranesp. 571
Cyclodextrins in Environment Sciences
Application of cyclodextrins in nuclear waste managementp. 577
Optimization of fuel oil desulfuration by [beta]-cyclodextrinp. 583
Inclusion of environmental contaminants with [beta]-cyclodextrin, and adsorption and removal by [beta]-cyclodextrin polymerp. 587
Luminescent behavior of Eu(nta)[subscript 3] dipy complex in the presence of [beta]-cyclodextrinsp. 591
Study of complexation between the pesticide chlorpyrifos and [beta]- and HP-[beta]-cyclodextrinsp. 595
Application of randomly methylated [beta]-cyclodextrin for bioremediation of contaminated soilp. 599
Cyclodextrins as Chiral Selectors
Modified cyclodextrins as versatile chiral stationary phases in flavour chemistry and life sciencesp. 605
[beta]-cyclodextrins as molecular scaffolds to reverse the regioselectivity of nitrile oxide cycloadditionsp. 609
Analysis and characterisation of commercial DM-[beta]-CD. Influence of mixture composition in chiral separation in capillary electrophoresis and supercritical fluid chromatographyp. 613
Pure monopentenylated [beta]-cyclodextrin as chiral agent: purity check by LC-ELSD and LC-MSp. 617
Cyclodextrins dominate the chiral chromographyp. 621
New asymmetric [beta]-cyclodextrin derivatives designed for chiral recognitionp. 625
Cyclodextrin Complexes and its Characterization
Study of the formation of the inclusion compound between rhodium (II)3-chlorocinnamate and [beta]-cyclodextrinp. 631
Formation of inclusion complex of cyclodextrin in organic solvents and alcohols under anhydrous conditionsp. 635
Inclusion complexes of UV filters in solution and in solid statep. 639
Encapsulation of porphyrins by [gamma]-cyclodextrinp. 645
Guest-dependent ordering of the self-assembled cyclodextrin inclusion complexes studied by scanning tunneling microscopyp. 649
The application of differential conductivity method to the determination of binding constant of [beta]-cyclodextrin with sodium perfluorooctanoatep. 653
Influence of the guest, the type and degree of substitution on inclusion complex formation of sustituted [beta]-cyclodextrinsp. 657
Reliable NMR experiments for the determination of the structure of cyclodextrin inclusion complexes in solutionp. 659
[superscript 1]H-NMR Circular dichroism and UV-visible spectroscopic study of inclusion complexes formation between o-, m- and p-hydroxyphenol and [beta]-cyclodextrinp. 663
Molar partial properties in host-guest systems: application to the inclusion complexes between [beta]-cyclodextrin and sodium alkanoatesp. 667
The binding of 2-naphthamides to [beta]-cyclodextrinp. 671
Publications - new products, is there any correlation?p. 675
Cyclodextrins in Food and Cosmetics
Preliminary study of dye sorption by various kinds of insoluble sorbents containing [beta]-cyclodextrinp. 681
Release characteristics of hydrophobic flavor encapsulated in cyclodextrinsp. 685
A [superscript 1]H-NMR study of inclusion compounds of model food flavours in [beta]-cyclodextrinp. 689
[beta]-cyclodextrin emulsion: mecanism of emulsification and application to the preparation of green metalworking fluidsp. 693
Subject indexp. 697
Table of Contents provided by Syndetics. All Rights Reserved.

ISBN: 9780792357216
ISBN-10: 0792357213
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 707
Published: 31st August 1999
Publisher: Springer
Country of Publication: NL
Dimensions (cm): 24.77 x 15.88  x 3.81
Weight (kg): 1.38