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Prion Diseases : Diagnosis and Pathogenesis

Diagnosis and Pathogenesis

By: M. H. Groschup (Editor), H. a. Kretzschmar (Editor), Martin H. Groschup (Editor)

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Paperback | 1 December 2000

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310 Pages

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27.94 x 20.96 x 1.65

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A comprehensive understanding of the biology of prion diseases is crucial for risk assessment as regards both humans and animals. To further the communication of the current knowledge and the exchange of diagnostic technologies in the scientific community, a symposium on the 'Characterization and Diagnosis of Prion Diseases' was held from September 23-25, 1999 in TA1/4bingen, Germany. The overwhelming interest and the participation of more than 500 scientists from 26 countries made this symposium the largest meeting ever held in the field. In this Supplementum to Archives of Virology twenty-six invited speakers comprehensively present their data on the pathogenesis of prion diseases in humans and animals, on molecular mechanisms involved in the transmissibility across species barriers, on animal and in-vitro models currently available for the detection and quantification of infectivity and on the characterization of prion strains. This selection attempts to reflect the current state of the art, but cannot possibly represent the whole spectrum of research in the prion field.

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Non-Fiction Medicine Clinical & Internal Medicine Diseases & Disorders Infectious & Contagious Diseases Neurology & Clinical Neurophysiology Other Branches of Medicine Pathology Medical Microbiology & Virology Medical Diagnosis Science Biology, Life Sciences

Microbiology excluding Medical

Prions: from neurografts to neuroinvasion	p. 3
Follicular dendritic cells in scrapie pathogenesis	p. 13
Cellular and sub-cellular localisation of PrP in the lymphoreticular system of mice and sheep	p. 23
Pharmacological manipulation of early PrP[superscript res] accumulation in the spleen of scrapie-infected mice	p. 39
Pathogenesis of natural scrapie in sheep	p. 57
Detection of cattle-derived BSE prions using transgenic mice overexpressing bovine PrP[superscript C]	p. 75
Analyzing the influence of PrP primary structure on prion pathogenesis in transgenic mice	p. 87
A single amino acid alteration in murine PrP dramatically alters TSE incubation time	p. 95
A transgenic model of a familial prion disease	p. 103
Transgenic models of prion disease	p. 113
Surveillance of BSE	p. 127
Histopathology and immunohistochemistry of human transmissible spongiform encephalopathies (TSEs)	p. 135
Pathology of variant Creutzfeldt-Jakob disease	p. 143
Clinical and differential diagnosis of Creutzfeldt-Jakob disease	p. 153
Putting prions into focus: application of single molecule detection to the diagnosis of prion diseases	p. 161
Detection of PrP[superscript Sc] in subclinical BSE with the paraffin-embedded tissue (PET) blot	p. 173
Sheep and goats: Natural and experimental TSEs and factors influencing incidence of disease	p. 181
Application of Prionics Western blotting procedure to screen for BSE in cattle regularly slaughtered at Swiss abattoirs	p. 189
Specific determination of the proteinase K-resistant form of the prion protein using two-site immunometric assays. Application to the post-mortem diagnosis of BSE	p. 197
PrP[superscript Sc] typing by N-terminal sequencing and mass spectrometry	p. 209
Characterization of BSE and scrapie strains/isolates	p. 217
Quantitative traits of prion strains are enciphered in the conformation of the prion protein	p. 227
Function of PrP[superscript C] as a copper-binding protein at the synapse	p. 239
The prion protein globular domain and disease-related mutants studied by molecular dynamics simulations	p. 251
Neurotoxicity but not infectivity of prion proteins can be induced reversibly in vitro	p. 265
Inhibition of formation of protease-resistant prion protein by Trypan Blue, Sirius Red and other Congo Red analogs	p. 277
The use of monoclonal antibody epitopes for tagging PrP in conversion experiments	p. 285
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Prion Diseases : Diagnosis and Pathogenesis

Diagnosis and Pathogenesis

At a Glance

Paperback

Shipping

How to return your order

Defective items

You Can Find This Book In

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