What use is physical chemistry to the student of biochemistry and biology? This central question is answered in this book mainly through the use of worked examples and problems. The book starts by introducing the laws of thermodynamics, and then uses these laws to derive the equations relevant to the student in dealing with chemical equilibria (including the binding of small molecules to proteins), properties of solutions, acids and bases, and oxidation-reduction processes. The student is thus shown how a knowledge of thermodynamic qualities makes it possible to predict whether, and how, a reaction will proceed.
Thermodynamics, however, gives no information about how fast a reaction will happen. The study of the rates at which processes occur (kinetics) forms the second main theme of the book. This section poses and answers questions such as how is the rate of a reaction affected by temperature, pH, ionic strength, and the nature of the reactants? These same ideas are then shown to be useful in the study of enzyme-catalysed reactions.
"Remarkably efficient [at] putting across conceptually difficult material ... Principles and Problems will continue to be essential reading for biochemistry undergraduates." The Biochemist, June 2002
INTRODUCTION1: The consequences of physics and chemistry for lifeTHE ENERGETICS OF CHEMICAL REACTIONS2: Basic thermodynamics3: Chemical potential and multiple component systems4: Binding of ligands to macromolecules5: Acids, bases and pH regulation6: Oxidation-reduction reactions and electrochemistry7: Properties of solutions8: Ideal and non-ideal systemsTHE RATES OF CHEMICAL REACTIONS9: Basic chemical kinetics and single-step reactions10: Applications of chemical kinetics to multi-step reactions11: Catalysis and enzyme kinetics12: Multi-substrate enzyme kinetics and enzyme inhibition13: Coupled reactions and biochemical pathwaysATOMIC AND MOLECULAR STRUCTURE14: Quantum mechanics: particles, waves and the quantization of energy15: Electrons in atoms16: Bonding in molecules17: Introduction to atomic and molecular spectroscopy18: Non-covalent interactions and macromolecular structureAPPENDICESA1: note on units and constantsA2: Mathematical tools needed for this textA3: Answers to problems
Tertiary; University or College
Number Of Pages: 424
Published: 6th September 2001
Publisher: Oxford University Press
Country of Publication: GB
Dimensions (cm): 24.5 x 19.0
Weight (kg): 0.76
Edition Number: 3
Edition Type: Revised