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Principles and Practices of Method Validation : Special Publication - A. Fajgelj

Principles and Practices of Method Validation

Special Publication

By: A. Fajgelj (Editor), A. Ambrus (Editor)

Hardcover Published: 3rd October 2000
ISBN: 9780854047833
Number Of Pages: 314

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Principles and Practices of Method Validation is an overview of the most recent approaches used for method validation in cases when a large number of analytes are determined from a single aliquot and where a larege number of samples are to be analysed. Much of the content relates to the validation of new methods for pesticide residue analysis in foodstuffs and water but the principles can be applied to other similar fields of analysis. Different chromatographic methods are discussed, including estimation of various effects, eg. matrix-induced effects and the influence of the equipment set-up. The methods used for routine purposes and the validation of analytical data in the research and development environment are documented. The legislation covering the EU-Guidance on residue analytical methods, an extensive review of the existing in-house method validation documentation and guidelines for single-laboratory validation of analytical methods for trace-level concentrations of organic chemicals are also included. With contributions from experts in the field, any practising analyst dealing with method validation will find the examples presented in this book a useful source of technical information

"...a remarkably useful book, which should be on the shelf of most analytical laboratories." * www.rsc.org/anlreview, January 2002 * "... any practising analyst dealing with method validation will find the examples presented in this book a useful source of technical information." * La Doc STI, No 390, Novembre 2000, p 18 *

The Potential Use of Quality Control Data to Validate Pesticide Residue Method Performancep. 1
Optimization and Evaluation of Multi-residue Methods for Priority Pesticides in Drinking and Related Watersp. 9
Validation of Analytical Data in a Research and Development Environmentp. 19
Performance Validation of a Multi-residue Method for 170 Pesticides in Kiwifruitp. 29
Effects of Sample Processing on Pesticide Residues in Fruit and Vegetablesp. 41
Testing the Efficiency and Uncertainty of Sample Processing Using [superscript 14]C-Labelled Chlorpyrifos: Part I. Description of the Methodologyp. 79
Testing the Efficiency and Uncertainty of Sample Processing Using [superscript 14]C-Labelled Chlorpyrifos: Part IIp. 59
Testing the Effect of Sample Processing and Storage on the Stability of Residuesp. 75
AOAC International Collaborative Study on the Determination of Pesticide Residues in Nonfatty Foods by Supercritical Fluid Extraction and Gas Chromatography/Mass Spectrometryp. 89
Validation of Analytical Methods--Proving Your Method is 'Fit for Purpose'p. 100
Validation of a Multi-residue Method for Analysis of Pesticides in Fruit, Vegetables and Cereals by a GC/MS Iontrap Systemp. 108
Development and Validation of a Generic Gas Chromatographic Method for the Determination of Organophosphorus Pesticide Residues in Various Sample Extractsp. 120
Validation of Gas Chromatographic Databases for Qualitative Identification of Active Ingredients of Pesticide Residuesp. 128
Estimation of Significance of 'Matrix-induced' Chromatographic Effectsp. 138
Worked Example for Validation of a Multi-residue Methodp. 157
EU Guidance Documents on Residue Analytical Methodsp. 176
Guidelines for Single-Laboratory Validation of Analytical Methods for Trace-level Concentrations of Organic Chemicalsp. 179
A Critique on Available In-House Method Validation Documentationp. 253
Subject Indexp. 297
Table of Contents provided by Syndetics. All Rights Reserved.

ISBN: 9780854047833
ISBN-10: 0854047832
Series: Special Publication
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 314
Published: 3rd October 2000
Country of Publication: GB
Dimensions (cm): 23.93 x 16.15  x 2.36
Weight (kg): 0.59

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