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Pre-Invasive Disease : Pathogenesis and Clinical Management - Rebecca C. Fitzgerald

Pre-Invasive Disease

Pathogenesis and Clinical Management

By: Rebecca C. Fitzgerald (Editor)

Hardcover

Published: 30th October 2010
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This book is written by International experts in their field and should appeal to students and seasoned researchers, to scientists and to clinicians. No prior knowledge of the topic is required to appreciate this text and yet the book charters new territory. New perspectives are given on how our knowledge of cancer development might lead us to reconsider our clinical approach to early detection and prevention of cancer at an individual and population level.

Pathogenesis
Stem Cells in Intraepithelial Neoplasiap. 3
The Inflammatory Tissue Microenvironment and the Early Stages of Malignancyp. 21
Hereditary Factors and Pre-invasive Diseasep. 31
Epigenetic Alterations as Contributors to the Pathogenesis, Detection, Prognosis and Treatment of Human Pre-Neoplasiap. 41
The Progression of Pre-Invasive to Invasive Cancerp. 65
Contribution of the-Omics Era to our Understanding of Pre-Invasive Disease and Progression to Cancerp. 77
Somatic Evolution in Neoplastic Progression and Cancer Preventionp. 111
Model Systems and Clinical Approaches
Precancer in animal Models: Sequentially Acquired or Predeterminedp. 131
Biomarkers for Detection of Intra-epithelial Neoplasiap. 151
Molecular Imaging of Cancer and the Implications for Pre-Invasive Diseasep. 167
Chemopreventionp. 209
Endoscopic Treatment of Early Lesions with Particular Reference to Barrett's Oesophagusp. 227
Psychosocial Outcomes of Screening for Cancer and Pre-invasive Diseasep. 245
Disease Specific Examples
Pre-invasive Disease of the Lungp. 271
Progress in Early Detection and Management of Oral Dysplasia: Components for a Multifaceted Progression Risk Modelp. 297
Barrett's Oesophagusp. 315
Helicobacter Infection: Infection, Immunity and the Progression of Lesions to Invasive Gastric Cancerp. 341
Pathways and Crossroads to Colorectal Cancerp. 369
Precursor Lesions of Pancreatic Cancerp. 395
Breast: Ductal Carcinoma In Situ (DCIS)p. 421
Molecular Pathogenesis, Detection and Clinical Management of Pre-invasive Cervical Lesionsp. 437
Pre-malignant Disease in the Prostatep. 467
Common Threads
Early Disease, Early Detection, Early Treatment: Some Common Threads and Some Important Problemsp. 495
Indexp. 509
Table of Contents provided by Ingram. All Rights Reserved.

ISBN: 9781441966933
ISBN-10: 1441966935
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 519
Published: 30th October 2010
Publisher: Springer-Verlag New York Inc.
Country of Publication: US
Dimensions (cm): 23.5 x 15.5  x 2.54
Weight (kg): 0.97