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Practical Bioinformatics : Nucleic Acids and Molecular Biology - Janusz M. Bujnicki

Practical Bioinformatics

Nucleic Acids and Molecular Biology

By: Janusz M. Bujnicki (Editor)

Hardcover Published: 1st April 2004
ISBN: 9783540206132
Number Of Pages: 265

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The book is unique in that. It bridges the gap between bioinformaticists and molecular biologists, i. e. the developers and the users of computational methods for biological data analysis and in that it presents examples of practical applications of the bioinformatics tools in the "daily practice" of an experimental research scientist. The book starts with reviews on computational methods for protein sequence-structure-function analysis (sequence studies, structure prediction), followed by methods that explicitly utilize experimental data routinely obtained in the laboratory to improve the functional predictions. The second part comprises a series of examples on how particular applications of different types of bioinformatics methods in combination with experimental studies to validate the hypotheses have led to important scientific discoveries. Therefore, the book is a guide to application of bioinformatics methods in molecular biology, addressed mainly to the research scientists, postdocs, and advanced graduate students.

Computational methods for protein structure prediction and fold recognitionp. 1
'Meta' approaches to protein structure predictionp. 23
From molecular modeling to drug designp. 35
Structure determination of macromolecular complexes by experiment and computationp. 73
Modeling protein folding pathwaysp. 97
Structural bioinformatics and NMR structure determinationp. 123
Bioinformatics-guided identification and experimental characterization of novel RNA methyltransferasesp. 139
Finding missing tRNA modification genes : a comparative genomics goldminep. 169
Evolution and function of processosome, the complex that assembles ribosomes in eukaryotes : clues from comparative sequence analysisp. 191
Bioinformatics-guided experimental characterization of mismatch-repair enzymes and their relativesp. 221
Predicting functional residues in DNA glycosylases by analysis of structure and conservationp. 243
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9783540206132
ISBN-10: 3540206132
Series: Nucleic Acids and Molecular Biology
Audience: General
Format: Hardcover
Language: English
Number Of Pages: 265
Published: 1st April 2004
Publisher: Springer-Verlag Berlin and Heidelberg Gmbh & Co. Kg
Country of Publication: US
Dimensions (cm): 22.86 x 15.24  x 1.75
Weight (kg): 0.55