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Positive Strand RNA Viruses : Neue Schriften Des Deutschen Stadtetages - Margo A. Brinton

Positive Strand RNA Viruses

Neue Schriften Des Deutschen Stadtetages

Paperback ISBN: 9783211825228
Number Of Pages: 558

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Positive-strand RNA viruses include the majority of the plant viruses, a number of insect viruses, and animal viruses, such as coronaviruses, togaviruses, flaviviruses, poliovirus, hepatitis C and rhinoviruses. This volume contains the contributions of over 50 leading laboratories on strategies for the control of virus diseases: molecular aspects of pathogenesis and virulence; genome replication and transcription; RNA recombination; RNA-protein interactions and host-virus interactions; protein expression and virion maturation; RNA replication; virus receptors; and virus structure and assembly. Highlights include analysis of the picornavirus IRES element, evidence for long-term persistence of viral RNA in host cells, acquisition of new genes from the host and other viruses via copy-choice recombination, identification of molecular targets and use of structural and molecular biological studies for development of novel antiviral agents.

Keynote address: The importance of antigenic variation in vaccine designp. 1
The genetic and functional basis of HIV-1 resistance to nonnucleoside reverse transcriptase inhibitorsp. 11
Structure-based design of symmetric inhibitors of HIV-1 proteasep. 19
Age-dependent susceptibility to fatal encephalitis: alphavirus infection of neuronsp. 31
Principles and background for the construction of transgenic plants displaying multiple virus resistancep. 41
The structure of an immunodominant loop on foot and mouth disease virus, serotype 01, determined under reducing conditionsp. 51
Immunopathologic mechanisms of dengue hemorrhagic fever and dengue shock syndromep. 59
Cardioviral poly(C) tracts and viral pathogenesisp. 67
Transgenic mice and the pathogenesis of poliomyelitisp. 79
Adaptation of positive-strand RNA viruses to plantsp. 87
A molecular genetic approach to the study of Venezuelan equine encephalitis virus pathogenesisp. 99
Use of drug-resistance mutants to identify functional regions in piconavirus capsid proteinsp. 111
Flock house virus: a simple model for studying persistent infection in cultured Drosophila cellsp. 121
Protein-protein interactions and glycerophospholipids in bromovirus and nodavirus RNA replicationp. 135
Characteristics of the poliovirus replication complexp. 147
Secretory pathway function, but not cytoskeletal integrity, is required in poliovirus infectionp. 159
Role of sub-genomic minus-strand RNA in coronavirus replicationp. 173
Common replication strategies emerging from the study of diverse groups of positive-strand RNA virusesp. 181
Preferential replication of defective turnip yellow mosaic virus RNAs that express the 150-kDa protein in cisp. 195
In vivo transfection by hepatitis A virus synthetic RNAp. 205
Recombination between Sindbis virus RNAsp. 213
Homologues RNA recombination allows efficient introduction of site-specific mutations into the genome of coronavirus MHV-A59 via synthetic co-replicating RNAsp. 221
Targeting of the site of nonhomologous genetic recombination in brome mosaic virusp. 231
Natural recombination in bovine viral diarrhea virusesp. 239
Sequences at the ends of RNA-2 of 16, a recombinant tobravirusp. 245
Identification and characterization of host factor interactions with cis-acting elements of rubella virus RNAp. 255
Interaction of cellular proteins with the poliovirus 5' noncoding regionp. 269
IRES-controlled protein synthesis and genome replication of poliovirusp. 279
Analysis of hepatitis A virus translation in a T7 polymerase-expressing cell linep. 291
Purification and characterization of the U-particle, a cellular constituent whose synthesis is stimulated by mengovirus infectionp. 299
B-lymphocytes are predominantly involved in viral propagation of hepatitis C virus (HCV)p. 307
Folding of the mouse hepatitis virus spike protein and its association with the membrane proteinp. 319
Assembly and entry mechanisms of Semliki Forest virusp. 329
The interactions of the flavivirus envelope proteins: implications for virus entry and releasep. 339
Coronavirus polyprotein processingp. 349
Processing of dengue type 4 and other flavivirus nonstructural proteinsp. 359
Nuclear targeting of Semliki Forest virus nsP2p. 369
Replication and translation of cowpea mosaic virus RNAs are tightly linkedp. 381
Alphavirus positive and negative strand RNA synthesis and the role of polyproteins in formation of viral replication complexesp. 393
Nodavirus RNA replication: mechanism and harnessing to vaccinia virus recombinantsp. 407
Molecular characterization of Borna virus RNAsp. 417
Genomic organization and expression of astroviruses and calcivirusesp. 429
Lelystad virus belongs to a new virus family, comprising lactate dehydrogenase-elevating virus, equine arteritis virus, and simian hemorrhagic fever virusp. 441
Recognition of cellular receptors by bovine coronavirusp. 451
Mouse hepatitis virus receptors: more than a single carcinoembryonic antigenp. 461
Host-cell receptors for Sindbis virusp. 473
Cell surface receptor for ecotropic host-range mouse retroviruses: a cationic amino acid transporterp. 485
Comparative studies of T = 3 and T = 4 icosahedral RNA insect virusesp. 497
Retroviral RNA packaging: a reviewp. 513
Structural studies of viruses by electron cryomicroscopyp. 523
Crystallographic and cryo EM analysis of virion-receptor interactionsp. 531
Assembly of tobacco mosaic virus and TMV-like pseudovirus particles in Escherichia colip. 543
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9783211825228
ISBN-10: 3211825223
Series: Neue Schriften Des Deutschen Stadtetages : Book 9
Audience: General
Format: Paperback
Language: English
Number Of Pages: 558
Country of Publication: AT
Dimensions (cm): 27.94 x 20.96  x 2.95
Weight (kg): 1.27
Edition Type: Revised