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Poly(ethylene glycol) : Chemistry and Biological Applications - J. Milton Harris

Poly(ethylene glycol)

Chemistry and Biological Applications

By: J. Milton Harris (Editor), Samuel Zalipsky (Editor)

Hardcover Published: 1st December 1997
ISBN: 9780841235373
Number Of Pages: 500

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This volume provides an interdisciplinary analysis of current biological applications of poly(ethylene glycol) (PEG). It includes a wide array of topics useful to materials scientists, organic chemists, biochemists, and bioengineers interested in drug delivery systems, pharmaceuticals and other biomaterials. The applications discussed include PEG-modified proteins, liposomes, drugs, surfaces of materials, and hydrogels. The volume also includes a review of PEG-oligonucleotides and a concise summary of the toxicology of PEG and its derivatives.

Preface
Introduction to Chemistry and Biological Applications of Poly(ethylene glycol)
Fundamental Properties of Poly(ethylene glycol)
Theory of Poly(ethylene glycol) in Solution
The Conformation of Polymers at Interfaces
Safety of Poly(ethylene glycol) and Poly(ethylene glycol) Derivatives
Poly(Ethylene Glycol)-Modified Liposomes and Particulates
Poly (ethylene glycol)-Grafted Liposome Therapeutics
Poly(ethylene oxide)-Bearing Lipids and Interaction of Functionalized Liposomes with Intact Cells
Poly(ethylene glycol)-Based Micelles for Drug Delivery
Protein Conjugates
The Use of Poly(ethylene glycol)-Enzymes in Nonaqueous Enzymology
Incorporation of Poly(ethylene glycol)-Proteins into Polymers
Biochemistry and Immunology of Poly(ethylene glycol)-Modified Adenosine Deaminase (PEG-ADA)
Conjugation of High-Molecular Weight Poly(ethylene glycol) to Cytokines: Granulocyte-Macrophage Colony-Stimulating Factors as Model Substrates
Preparation and Characterization of Poly(ethylene glycol)ylated Human Growth Hormone Antagonist
New Synthetic Polymers for Enzyme and Liposome Modification
Covalent and Noncovalent Adducts of Proteins with Water-Soluble Poly(alkylene oxides)
Isolation of Positional Isomers of Mono-poly(ethylene glycol)ylated Interferon/a-2a and the Determination of Their Biochemical and Biological Characteristics
Conjugates of Ollgomeric and Low-Molecular Weight Substrates
Site-Specific Poly(ethylene glycol)ylation of Peptides
Poly(ethylene glycol)-Containing Supports for Solid -Phase Synthesis of Peptides and Combinatorial Organic Libraries
Oligonucleotide-Poly(ethylene glycol) Conjugates: Synthesis, Properties, and Applications
Design of Antitumor Agent-Terminated Poly(ethylene glycol) Conjugate as Macromolecular Prodrug
Poly(ethylene glycol)-Grafted Polymers as Drug Carriers
New Functional Polymers, Surfaces, and Hydrogels
Hydrazide Derivatives of Poly(ethylene glycol) and Their Bioconjugates
Protein Adsorption of Poly(ethylene oxide)-Grafted Silicon Surfaces
Using Self-Assembled Monolayers That Present Oligo(ethylene glycol) Groups To Control the Interactions of Proteins with Surfaces
Electrokinetic Analysis of Poly(ethylene glycol) Coating Chemistry
Surface Modifications with Adsorbed Poly(ethylene oxide)-Based Block Copolymers Physical Characteristics and Biological Use
In vivo Stability of Poly(ethylene glycol)-Collagen Composites
Temperature-Induced Gelation Pluronic-g-Poly(acrylic acid) Graft Copolymers for Prolonged Drug Delivery to the Eye
Novel Degradable Poly(ethylene glycol) Esters for Drug Delivery
Author Index
Affiliation Index
Table of Contents provided by Publisher. All Rights Reserved.

ISBN: 9780841235373
ISBN-10: 0841235376
Series: ACS Symposium Series
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 500
Published: 1st December 1997
Publisher: American Chemical Society
Country of Publication: US
Dimensions (cm): 23.4 x 15.6  x 2.9
Weight (kg): 0.91