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Placental Bed Disorders : Basic Science and its Translation to Obstetrics - Robert Pijnenborg

Placental Bed Disorders

Basic Science and its Translation to Obstetrics

By: Robert Pijnenborg (Editor), Ivo Brosens (Editor), Roberto Romero (Editor)

Hardcover Published: 12th July 2010
ISBN: 9780521517850
Number Of Pages: 320

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The role of the placental bed in normal pregnancy and its complications has been intensively Investigated for 50 years. It is now recognized that disorders of the maternal-fetal interface in humans are implicated in a broad range of pathologic conditions, including spontaneous abortion, preterm labor, preterm premature rupture of membranes, pre-eclampsia, intrauterine growth restriction, abruptio placentae, and fetal death.Moreover, recent evidence indicates that these disorders have the potential to reprogram the endocrine, metabolic, vascular, and immune responses of the human fetus, and predispose to adult diseases.

The aim of the book is to inform the reader about the exciting developments in the study of the placental bed as well as the novel approaches to the assessment of this unique tissue interface and its implications for the diagnosis and treatment of complications of pregnancy. This book will be a resource to those intersted in clinical obstetrics, maternal-fetal medicine, perinatal pathology, neonatology, and reproductive medicine. Those interested in imaging of the maternal-fetal circulation or its interrogation with Doppler would also benefit from the information presented.

'... a really excellent and timely volume (especially given Robert's retirement), scholarly, comprehensive, well presented, critical, stimulating in the presentation of new ideas and with an authoritative panel of contributors.' Professor John Aplin, Maternal and Fetal Health Research Group, University of Manchester
'The distinctly individual writing style of the contributors keeps the reader engaged and their interpretation of published literature provides a unique insight into placental bed research and exposes the controversies that still exist ... I thoroughly recommend this book to every obstetrician and basic science researcher who is interested in the field of maternal-fetal and perinatal medicine.' Acta Obstetricia et Gynecologia Scandinavica

Preface
Introducing the Placental Bed
The placental bed in a historical perspective
Unraveling the anatomy
Placental Bed Vascular Disorders
Defective spiral artery remodelling
What is defective: decidua, trophoblast or both?
Uterine Vascular Environment
Decidualisation
Uterine NK cells
Placental angiogenesis
Oxygen delivery at the deciduo-placental interface
Deep Placentation
The junctional zone myometrium
Subendometrial spiral artery blood flow and pregnancy rate Ernest
Deep trophoblast invasion and spiral artery remodelling
Comparative Anatomy and Research Models
Comparative anatomy and placental evolution
Animal models of deep trophoblast invasion
Trophoblast-arterial interactions in vitro
Long-term effects of uteroplacental insufficiency in animals
Genetics
Fertile soil or no man's land: a partial history of the placental bed
Search for susceptibility genes
Imprinting Gudrun Moore and Sayeda
Risk Factors, Predictors and Future Management
Risk factors of pre-eclampsia and SGA
Angiogenic factors and pre-eclampsia May
Assisted reproductive technology and the risk of poor pregnancy outcome Marc
Periconceptual and early pregnancy approach Gordon
New concepts and recommendations on clinical management and research
Disorders of the placental bed in the genesis of the great obstetrical syndromes
Index
Table of Contents provided by Publisher. All Rights Reserved.

ISBN: 9780521517850
ISBN-10: 0521517850
Series: Cambridge Medicine (Hardcover)
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 320
Published: 12th July 2010
Publisher: Cambridge University Press
Country of Publication: GB
Dimensions (cm): 25.3 x 19.5  x 2.0
Weight (kg): 0.86