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Physical Methods to Characterize Pharmaceutical Proteins : Pharmaceutical Biotechnology - James N. Herron

Physical Methods to Characterize Pharmaceutical Proteins

Pharmaceutical Biotechnology

By: James N. Herron (Editor), Wim Jiskoot (Editor), Daan J. A. Crommelin (Editor)

Hardcover Published: 30th September 1995
ISBN: 9780306450266
Number Of Pages: 362

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Proteins are still gaining importance in the pharmaceutical world, where they are used to improve our arsenal of therapeutic drugs and vaccines and as diagnostic tools. Proteins are different from "traditional" low-molecular-weight drugs. As a group, they exhibit a number of biopharmaceutical and formulation problems. These problems have drawn considerable interest from both industrial and aca- demic environments, forcing pharmaceutical scientists to explore a domain previ- ously examined only by peptide and protein chemists. Biopharmaceutical aspects of proteins, e.g., low oral bioavailability, have been extensively investigated. Although all possible conventional routes of ad- ministration have been examined for proteins, no real, generally applicable alter- native to parenteral administration in order to achieve systemic effects has yet been discovered. Several of these biopharmaceutical options have been discussed in Volume 4 of this series, Biological Barriers to Protein Delivery. Proteins are composed of many amino acids, several of which are notorious for their chemical instability. Rational design of formulations that optimize the native structure and/or bioactivity of a protein is therefore of great importance when long shelf life is required, as it is for pharmaceutical products. This issue has also been examined in two prior volumes of this series: Volume 2: Stability of Protein Pharmaceuticals (Part A) and Volume 5: Stability and Characterization of Protein and Peptide Drugs.

Application of Fluorescence Spectroscopy for Determining the Structure and Function of Proteins
Structural Information on Proteins from Circular Dichroism Spectroscopy: Possibilities and Limitations
Fourier Transform Infrared Spectroscopy Investigations of Protein Structure
Mass Spectrometry in Protein Structural Analysis
Two-, Three-, and Four-Dimensional Nuclear Magnetic Resonance Spectroscopy of Protein Pharmaceuticals
Thermodynamic Strategies for Rational Protein and Drug Design
Chromatographic Techniques for the Characterization of Proteins
Capillary Electrophoresis of Proteins
Applying Genetic Engineering to the Structural Analysis of Proteins
Index
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780306450266
ISBN-10: 0306450267
Series: Pharmaceutical Biotechnology
Audience: General
Format: Hardcover
Language: English
Number Of Pages: 362
Published: 30th September 1995
Publisher: SPRINGER VERLAG GMBH
Country of Publication: US
Dimensions (cm): 23.39 x 15.6  x 2.24
Weight (kg): 0.71
Edition Number: 22

Earn 678 Qantas Points
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