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Photostability of Drugs and Drug Formulations, Second Edition - Hanne Hjorth Tonnesen

Photostability of Drugs and Drug Formulations, Second Edition

By: Hanne Hjorth Tonnesen (Editor)

Hardcover Published: 1st June 2004
ISBN: 9780415303231
Number Of Pages: 448

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Providing the guidance needed for formulation, handling, and quality control of photolabile drugs, Photostability of Drugs and Drug Formulations, Second Edition explores the significance of new information on drug photoreactivity in a pharmaceutical context. Completely revised and updated, with chapter authors drawn from an international panel of experts, the book supplies the background necessary for planning standardized photochemical stability studies as a part of drug development and formulation work. It contains comprehensive coverage of the physical and chemical aspects of drug photoreactivity, formulation, stability testing, and drug design/discovery in one resource.
The contents have been reorganized to focus on the standardization of photostability testing of drug substances and products, in vitro photoreactivity screening of drugs, and various aspects of the formulation of photoreactive substances. The information on in vitro screening of drug photoreactivity is of great relevance for scientists who are developing and validating a set of testing protocols to address photosafety. Discussing kinetic and chemical aspects of drug photodecomposition as well as the practical problems frequently encountered in photochemical stability testing, this book helps you design a test protocol and interpret the results.
Assists non-experts in this field design a test protocol and interpret the results
Covers in vitro and in vivo aspects of interactions between drugs and light
Explores the kinetic and chemical aspects of drug photodecomposition
Discusses the problems frequently encountered in photochemical stability testing
Provides guidance on how to address photosafety assessments and labeling requirements of potentially photoreactive drugs
Highlights the practical implications of drug photodecomposition from a pharmaceutical viewpoint
Offers specific guidance in photostability testing and screening of drug photoreactivity

Introduction: Photostability Testing of Drugs and Drug Formulations--Why and How?p. 1
Photophysical and Photochemical Aspects of Drug Stabilityp. 9
Standardization of Kinetic Studies of Photodegradation Reactionsp. 41
Rationalizing the Photochemistry of Drugsp. 67
Technical Requirements and Equipment for Photostability Testingp. 111
Photostability Testing: Design and Interpretation of Tests on New Drug Substances and Dosage Formsp. 137
The Questions Most Frequently Askedp. 161
Inconsistencies and Deficiencies in Current Official Regulations Concerning Photolytic Degradation of Drugsp. 173
Biological Effects of Combinations of Drugs and Lightp. 189
In Vitro Screening of the Photoreactivity of Antimalarials: A Test Casep. 213
Screening Dyes, Drugs, and Dietary Supplements for Ocular Phototoxicityp. 235
Photochemical and Photophysical Methods Used in Study of Drug Photoreactivityp. 255
Addressing the Problem of Light Instability during Formulation Developmentp. 285
Photostability of Parenteral Productsp. 303
Photoactivated Drugs and Drug Formulationsp. 331
Formulation Approaches for Improving Solubility and Its Impact on Drug Photostabilityp. 351
Useful Terms and Expressions in the Photoreactivity Testing of Drugsp. 373
Relevant Literature on the Photostability of Specific Drug Substances and Drug Formulationsp. 377
Indexp. 415
Table of Contents provided by Rittenhouse. All Rights Reserved.

ISBN: 9780415303231
ISBN-10: 0415303230
Audience: Tertiary; University or College
Format: Hardcover
Language: English
Number Of Pages: 448
Published: 1st June 2004
Country of Publication: GB
Dimensions (cm): 23.5 x 15.88  x 2.54
Weight (kg): 0.75
Edition Number: 2
Edition Type: New edition