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Pharmacological Control of Calcium and Potassium Homeostasis : Biological, Therapeutical, and Clinical Aspects - T. Godfraind

Pharmacological Control of Calcium and Potassium Homeostasis

Biological, Therapeutical, and Clinical Aspects

By: T. Godfraind (Editor), Guiseppe Mancia (Editor), Maria P. Abbracchio (Editor), L. Aguilar-Bryan (Editor), S. Govoni (Editor)

Hardcover Published: 31st July 1995
ISBN: 9780792336044
Number Of Pages: 275

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As the number of drugs acting on calcium and potassium channels grows, there is a need for a continuous reappraisal of the cellular machinery controlling them. The present volume provides an update on the basic knowledge, the molecular targets of the two channels, and the importance the drugs that bind them have as pharmacological tools and therapeutic agents. This work was presented at the 6th International Symposium on PHARMACOLOGICAL CONTROL OF CALCIUM AND POTASSIUM HOMEOSTASIS: BIOLOGICAL, THERAPEUTICAL, AND CLINICAL ASPECTS, in Florence (Italy) on October 4-6, 1994. Because of the recent advances in the field, discussions on potassium channels were included for the first time. At least six classes of voltage-dependent calcium channels have been defined based on their physiological and pharmacological properties. Among them, L-type channels, mediating long lasting currents, are better characterized. Calcium homeostasis within the cell is not only regulated by calcium channels; intracellular calcium stores, in particular a pool contained in the lumen of specialized areas of the endoplasmic reticulum, are rapidly exchanged with the cytoplasm and playa key role in the control of calcium homeostasis. This area, however, has not yet been exploited from a therapeutic point of view. Potassium channels are present in virtually every cell type, excitable and nonexcitable, and are distinguished by structural, biophysical, and pharmacological criteria. Different classes including voltage-gated, ligand-gated, AP-sensitive, and G-protein coupled among others, have been defined by their primary regulatory and gating mechanisms.

Preface
List of Contributors
cAMP-Dependent Phosphorylation of the L-Type Calcium Channel: Biochemical Characterization and Physiological Regulationp. 1
Integration of Plasmalemmal and Sarcoplasmic Reticular Ca2[superscript +] Transport in Smooth Musclep. 9
Oligomeric and Subunit Structures of Voltage-Gated Potassium Channelsp. 17
Modulation of K+ Channels: Pharmacological and Therapeutic Aspectsp. 23
Calcium Channels and Regulation of Vascular Tone in Hypertensionp. 43
Calcium and Calcium Channel Regulation in Cardiac Functionp. 57
Adenosine and ATP-Regulated Ion Currents in Cardiomyocytesp. 65
Endothelium-Dependent Hyperpolarization and Potassium Channelsp. 73
Potassium Channels in the Regulation of Vascular Smooth Muscle Tonep. 85
The Importance of Potassium for Vascular Protection in a Hypertensive Settingp. 95
The Antiatherosclerotic Effect of Calcium Antagonistsp. 103
Clinical Pharmacology of Calcium Antagonists as Antihypertensivesp. 111
Cardioprotection by Calcium Antagonists: Myocardial Ischemia and Secondary Preventionp. 119
Actions of Insulin and IGF-I on Vascular Smooth Muscle Cation and Glucose Metabolismp. 129
The Prevention of Vascular Injury in a Genetic Model of Hypertensionp. 139
Calcium Antagonists and Renal Protection: Current Status and Future Perspectivesp. 147
The Reversal of Hypertension-Induced Cardiac Damage by Antihypertensive Therapy with Calcium Antagonistsp. 159
Rationale for Combined Therapy with Calcium Antagonists and ACE Inhibitorsp. 167
Does the Combination of an ACE Inhibitor and a Calcium Antagonist Enhance Cardioprotection?p. 173
Hypertension in Diabetic Patients: How to Preserve Renal Functionp. 181
Multicenter Isradipine Diuretic Atherosclerosis Study (MIDAS): Rationale, Design, and Description of Trial Patientsp. 189
Metabolic Changes Associated with Isradipine and Hydrochlorothiazide in MIDAS: Effects on Serum Cations and Uric Acidp. 195
Ionic Metabolism in Cerebral Ischemiap. 199
New Directions in Cerebral Ischemia: Sodium and Calcium Channel Modulatorsp. 209
Acute Ischemic Stroke Therapyp. 219
Potassium Channels and Internal Calcium Release: Relevance for Memory Storage and Alzheimer's Diseasep. 227
Molecular Physiology of a Novel cGMP-Gated Potassium Channelp. 237
ATP-Dependent K+ Channels in Vascular Smooth Musclep. 247
Potassium Channel Openers in Therapy: Current Use and Perspective in Hypertensionp. 255
Potassium Channel Openers in Therapy, Current Uses, and Perspectives: Cardiac Ischemia and Anginap. 263
Indexp. 271
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780792336044
ISBN-10: 0792336046
Series: Medical Science Symposia
Audience: General
Format: Hardcover
Language: English
Number Of Pages: 275
Published: 31st July 1995
Publisher: SPRINGER VERLAG GMBH
Country of Publication: NL
Dimensions (cm): 23.39 x 15.6  x 1.75
Weight (kg): 0.59

Earn 587 Qantas Points
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