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Patient-Specific Modeling of the Cardiovascular System : Technology-Driven Personalized Medicine - Roy C. P. Kerckhoffs

Patient-Specific Modeling of the Cardiovascular System

Technology-Driven Personalized Medicine

Hardcover Published: 9th September 2010
ISBN: 9781441966902
Number Of Pages: 240

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Peter Hunter Computational physiology for the cardiovascular system is entering a new and exciting phase of clinical application. Biophysically based models of the human heart and circulation, based on patient-specific anatomy but also informed by po- lation atlases and incorporating a great deal of mechanistic understanding at the cell, tissue, and organ levels, offer the prospect of evidence-based diagnosis and treatment of cardiovascular disease. The clinical value of patient-specific modeling is well illustrated in application areas where model-based interpretation of clinical images allows a more precise analysis of disease processes than can otherwise be achieved. For example, Chap. 6 in this volume, by Speelman et al. , deals with the very difficult problem of trying to predict whether and when an abdominal aortic aneurysm might burst. This requires automated segmentation of the vascular geometry from magnetic re- nance images and finite element analysis of wall stress using large deformation elasticity theory applied to the geometric model created from the segmentation. The time-varying normal and shear stress acting on the arterial wall is estimated from the arterial pressure and flow distributions. Thrombus formation is identified as a potentially important contributor to changed material properties of the arterial wall. Understanding how the wall adapts and remodels its material properties in the face of changes in both the stress loading and blood constituents associated with infl- matory processes (IL6, CRP, MMPs, etc.

Integrating State-of-the-Art Computational Modeling with Clinical Practice: The Promise of Numerical Methodsp. 1
Patient-Specific Modeling of Cardiovascular Dynamics with a Major Role for Adaptationp. 21
Patient-Specific Modeling of Structure and Function of Cardiac Cellsp. 43
Studies of Therapeutic Strategies for Atrial Fibrillation Based on a Biophysical Model of the Human Atriap. 63
Patient-Specific Modeling for Critical Carep. 81
Biomechanical Analysis of Abdominal Aortic Aneurysmsp. 95
The Cardiac Atlas Project: Towards a Map of the Heartp. 113
In Vivo Myocardial Material Properties and Stress Distributions in Normal and Failing Human Heartsp. 131
Modeling of Whole-Heart Electrophsiology and Mechanics: Toward Patient-Specific Simulationsp. 145
Personalized Computational Models of the Heart for Cardiac Resynchronization Therapyp. 167
Patient-Specific Modeling of Hypoxic Response and Microvasculature Dynamicsp. 183
A Computational Framework for Patient-Specific Multi-Scale Cardiac Modelingp. 203
Appendix: Mathematical Modeling Language Code for the Hemodynamic Model in Fig.5.1bp. 225
Biographyp. 229
Indexp. 231
Table of Contents provided by Ingram. All Rights Reserved.

ISBN: 9781441966902
ISBN-10: 1441966900
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 240
Published: 9th September 2010
Country of Publication: US
Dimensions (cm): 23.37 x 15.49  x 2.03
Weight (kg): 0.5