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Pathophysiology and Clinical Applications of Nitric Oxide : Endothelial Cell Research - Gabor M. Rubanyi

Pathophysiology and Clinical Applications of Nitric Oxide

Endothelial Cell Research

By: Gabor M. Rubanyi (Editor)

Hardcover Published: 23rd June 1999
ISBN: 9789057024153
Number Of Pages: 660

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Research on the key mediator nitric oxide has increased exponentially over the last ten years. It is now clear that, in addition to its role within the cardiovascular system, this mediator is also implicated in the normal physiological function and disease pathology of several organs and systems. A number of the fundamental research observations are now being developed into therapeutic principles and these are being pursued through clinical trials. This is the first work summarizing, in its two volumes, the quantum leap from basic science to clinical applications emerging from this decade of research.

Prefacep. xi
Contributorsp. xiii
The Beginnings of Research on Nitric Oxide in Biology: A Historical Perspectivep. 1
Generation and Biological Actions of Nitric Oxide
Structural Variations on a Theme of Nitric Oxide Production by Three Isoforms of Nitric Oxide Synthasep. 17
Nitric Oxide Synthase Gene Regulationp. 39
Localization and Subcellular Targeting of Nitric Oxide Synthasesp. 51
Molecular Mechanisms of Peroxynitrite Reactivityp. 59
Nitric Oxide, Peroxynitrite and Poly (ADP-Ribose) Synthetase: Biochemistry and Pathophysiological Implicationsp. 69
Nitric Oxide and Gene Transcriptionp. 99
Nitric Oxide and the Regulation of Vasoactive Genesp. 121
Cyclooxygenase: An Important Transduction System for the Multifaceted Roles of Nitric Oxidep. 155
Regulation of Nitric Oxide Synthase Expression and Activity by Hemodynamic Forcesp. 171
Nitric Oxide Synthase Regulation by 17[beta]-Estradiolp. 195
Mice Deficient in eNOS and nNOS Isoformsp. 209
Indexp. 1
Nitric Oxide and Pathophysiology of Diseases
Nitric Oxide and Its Role in Hemostasisp. 229
Hypertensionp. 251
Pulmonary Hypertensionp. 267
Atherosclerosis: Role of Nop. 283
Nitric Oxide in Myocardial and Splanchnic Ischaemia/Reperfusionp. 301
Nitric Oxide and Circulatory Shockp. 323
Kidney Diseasesp. 335
The Role of Nitric Oxide in Preterm Labour and Pre-eclampsiap. 349
Multiple Sclerosisp. 375
Regulation of Nitric Oxide and Inflammatory Mediators in Human Osteoarthritis-Affected Cartilage: Implication for Pharmacological Interventionp. 397
The Role of Nitric Oxide in Rheumatoid Arthritisp. 413
Gastrointestinal Function in Shockp. 425
Therapeutic Applications
Nitric Oxide Donorsp. 455
Nitric Oxide Inhalationp. 471
Nitric Oxide Synthase Inhibitorsp. 505
The Pharmacology of Peroxynitrite-Dependent Neurotoxicity Blockadep. 523
Hemoglobin: Its Role as a Nitric Oxide Scavengerp. 539
Therapeutic Implications of Recombinant Endothelial Nitric Oxide Synthase Gene Expression in Cerebral and Peripheral Arteriesp. 555
Gene Therapy Approaches with iNOSp. 569
Indexp. 1
Table of Contents provided by Syndetics. All Rights Reserved.

ISBN: 9789057024153
ISBN-10: 9057024152
Series: Endothelial Cell Research
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 660
Published: 23rd June 1999
Publisher: Taylor & Francis Ltd
Country of Publication: GB
Dimensions (cm): 26.67 x 19.05  x 6.35
Weight (kg): 1.85
Edition Number: 1

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