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Pain and Neurogenic Inflammation : Progress in Inflammation Research - Susan D. Brain

Pain and Neurogenic Inflammation

Progress in Inflammation Research

Hardcover

Published: 1st December 1998
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Pain and inflammation are inextricably linked phenomena. The observation that chemical mediators with combined pro-inflammatory, algesic and/or hyperalgesic activity occur at the site of inflammation is fundamental not only to our present understanding of the inflammatory process but also to our attempts to devise clini­ cally useful anti-inflammatory therapies. Over a hundred years ago it was recognised that primary sensory neurones play a crucially important "dual" role in inflammation. By affecting the transfer of infor­ mation from peripheral nociceptors to the spinal cord, a subpopulation of sensory nerves {"pain fibres"} initiate algesia and hyperalgesia, whose sensations are then modified and fine-tuned in the central nervous system. Equally important is the release from the peripheral terminals of sensory neurones of neuropeptides, the acute effects of which are observed as changes in microvascular tone and perme­ ability leading to neurogenic inflammation. Over the last decade it has become increasingly clear that this view of the func­ tion of sensory nerves is somewhat over-simplified. For example, the mechanisms underlying hyperalgesia may, in certain circumstances, be mimicked in other condi­ tions such as the hypersensivity associated with asthma. Furthermore, it has become increasingly evident that over a longer time period the release of neuropeptides from peripheral sensory nerve endings may also have modulating effects on inmune cells and that this may be relevant to chronic inflammatory disease and possibly also to inflammatory hyperalgesia.

List of contributors
Preface
A comparative discussion of A[delta] and C fibres in different tissuesp. 1
The roles of spinal receptors in nociceptive responsesp. 23
Cutaneous hyperalgesiap. 39
Capsaicin and pain mechanismsp. 61
Nitric oxide and inflammatory painp. 81
Interactions between kinins and the inflammatory pain processp. 103
Sensory neuropeptides, neurogenic inflammation and inflammatory cellsp. 115
Inflammatory pain and the jointp. 137
Nerve growth factor and sensory nerve functionp. 167
The relationship between hyperalgesia and hyperresponsiveness in the lungp. 195
Neuropeptides and the respiratory tract: Relevance to asthma and rhinitisp. 207
Neuropeptides and the gut: Tachykinins and calcitonin gene-related peptide in intestinal inflammation and painp. 225
Regulation of meningeal blood flow by neuropeptides: Relevance to migrainep. 245
Sensory peptides: Effects in ageing and wound healingp. 275
Calcitonin gene-related peptides and their receptorsp. 297
Tachykinin receptors and the potential of tachykinin antagonists as clinically effective analgesics and anti-inflammatory agentsp. 313
Subject indexp. 335
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9783764358754
ISBN-10: 3764358750
Series: Progress in Inflammation Research
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 348
Published: 1st December 1998
Publisher: Birkhauser Verlag AG
Country of Publication: CH
Dimensions (cm): 23.5 x 15.5  x 2.06
Weight (kg): 1.51