Oral tolerance is a major immunological property of the gastrointestinal mucosa. It plays a critical role in immune defence by preventing inflammatory and allergic responses to dietary and non pathogenic microbial antigens. The interest in oral tolerance has been renewed in the recent years, due to novel insights on its cellular mechanisms and potential clinical applications in the treatment of autoimmune diseases.
Oral Tolerance: Cellular and Molecular Basis, Clinical Aspects, and Therapeutic Potential, has been designed as a concise yet comprehensive overview of the newest fundamental and clinical advances in the field. Based on the outstanding contribution of world experts, this book will be helpful to students, clinicians, and researchers working in mucosal immunology and gastroenterology.
The first part of this volume describes the structure and functions of the gastrointestinal mucosa and the fundamental features and mechanisms of oral tolerance, including the role of T cells, cytokines, IgA antibodies, and bacterial antigens. The second part explores the clinical implications of the disruption of oral tolerance in Inflammatory Bowel Diseases, food and milk allergies, and coeliac disease in particular. The final chapter focuses on the clinical potential of oral tolerance as a promising therapeutic tool.
|Structure and function of the gastrointestinal mucosa||p. 1|
|Oral tolerance : an overview||p. 12|
|A revisit of current dogma for the cellular and molecular basis of oral tolerance||p. 39|
|The role of T cells in the intestinal mucosa||p. 52|
|Cytokines, cyclooxygenases and oral tolerance||p. 64|
|IgA and mucosal homeostasis||p. 81|
|Induction of tolerogenic versus pathogenic mucosal immune responses by commensal enteric bacteria||p. 113|
|Food and milk allergies||p. 131|
|Physiopathology of celiac disease||p. 151|
|Clinical applications of oral tolerance||p. 164|
|Table of Contents provided by Blackwell. All Rights Reserved.|
Series: Medical Intelligence Unit
Number Of Pages: 208
Published: 10th August 2004
Publisher: Springer Science+Business Media
Country of Publication: US
Dimensions (cm): 23.5 x 15.5 x 1.91
Weight (kg): 1.09