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Oncogene and Transgenics Correlates of Cancer Risk Assessments

By: Constantine Zervos (Editor)

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Hardcover
368 Pages

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26.7 x 17.8 x 2.5

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A product of the NATO Advanced Research Workshop on [title], held in Attiki, Greece, October 1991, this volume advances the state of the art of cancer risk assessment methods by identifying potential short and long term contributions to such methods from the fundamental biological disciplines, i.e.

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You Can Find This Book In

Non-Fiction Medicine Clinical & Internal Medicine Diseases & Disorders Oncology Medicine in General Public Health & Preventive Medicine Infectious & Contagious Diseases Science Biology, Life Sciences Life Sciences in General Genetics excluding Medical

Other Branches of Medicine Pharmacology Biochemistry Botany & Plant Sciences Zoology & Animal Sciences

Cancer Risk Assessments: An Overview	p. 1
Pharmacodynamic Models for Cancer Risk Assessment	p. 21
Predictive Value for Cancer Risk Assessment of Cell- And Tissue-Specific Formation of Carcinogen-DNA Adducts	p. 31
Studies on the Role of Protein Kinase C in Multistage Carcinogenesis and Their Relevance to Risk Extrapolation	p. 43
Oncogene Activation and Human Cancer	p. 61
Genetics of Hepatocarcinogenesis in Mouse and Man	p. 67
Protein Kinase C in Carcinogenesis: Comparative Expression of Oncogenes and Protein Kinase C in Rhabdomyosarcoma Models	p. 81
Oncogenes and Human Cancers	p. 91
'In Vivo' Model Systems to Study ras Oncogene Involvement in Carcinogenesis	p. 111
K-ras Oncogene Activation in Neoplasias of Patients With Familial Adenomatous Polyposis Or Kidney Transplant	p. 127
An Overview of Transgenic Mice as Future Models of Human Diseases, in Drug Development, and for Genotoxicity and Carcinogenesis Studies	p. 133
Regulating Gene Expression in Mammalian Cell Culture and Transgenic Mice With Yeast GAL4/UAS Control Elements	p. 155
Genes and Oncogenes of the ras Superfamily	p. 173
Oncogenic Transgenic Mice in the Study of Carcinogenesis	p. 185
Leukemia, Lymphoma, Embryonic Carcinoma and Hepatoma Induced in Transgenic Rabbits by the c-myc Oncogene Fused With Immunoglobulin Enhancers	p. 199
An Overview of the Outstanding Issues in the Risk Assessment of Methylene Chloride	p. 217
Cancer Dose-Response Modeling and Methylene Chloride	p. 231
Risk Assessments for Benzene-Induced Leukemia - A Review	p. 241
Comparative Metabolism and Genotoxicity Data on Benzene: Their Role in Cancer Risk Assessment	p. 263
Dose-Response Relationships for Benzene: Human and Experimental Carcinogenicity Data	p. 293
A Threshold for Benzene Leukemogenesis	p. 305
Some Points for Discussion from the Oncogene Workshop	p. 313
Concluding Remarks, Findings and Recommendations	p. 319
Index	p. 333
Table of Contents provided by Blackwell. All Rights Reserved.

Oncogene and Transgenics Correlates of Cancer Risk Assessments

At a Glance

Hardcover

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How to return your order

Defective items

You Can Find This Book In

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