Prasad and Meysken's new volume on Nutrients and Cancer Prevention highlights the rapid progress now being made in understanding the role of specific nutrients in the prevention and treatment of neoplastic disease.
Nutritional oncology today focuses on the mechanisms of carcinogenesis and their modification by nutrients, as indicated by cancer prevention studies in animals and humans. This unique book takes into account evidence from human intervention studies using one or more nutrients in a population at increased risk for developing certain types of cancer.
International experts contribute chapters paying special attention to: mechanisms of carcinogenesis a roles of carotenoids, retinoids, vitamin E, protease inhibitors, fatty acids, and selenium a nutritional causes of colon cancer a preliminary results of intervention trials a use of retinoids, vitamin D, vitamin B6, and vitamin B1 in cancer treatment.
Everyone involved in oncology, nutrition, pharmacology, cell biology, epidemiology, and related fields-whether in basic research or at the clinical level-will find Nutrients and Cancer Prevention a comprehensive source of information on this critically important topic.
Nutrition and Cancer: An Overview of Present Reality and Future Goals. Mechanisms of Carcinogenesis. Two Operational Modes of Transmembrane Migration of Cyclic GMP Signal Pathway. Mechanisms of Action of Nutrients in Cancer Prevention. Counteractions of Retinoic Acid and Phorbol Ester Tumor Promoter Related to Changes in Protein Kinase Activities. Effect of Alpha Tocopheryl Succinate on Cell Differentiation and Adenylate Cyclase System. Effect of Nutrition on Carcinogenesis: Mechanisms Involving Nitrosamines. Mechanisms in Cancer Prevention by Dietary Antioxidants. Effects of Protease Inhibitors and Vitamin E in the Prevention of Cancer. Carotenoids Inhibit Chemically- and Physically-Induced Neoplastic Transformation During the Post-Initiation Phase of Carcinogenesis. Fatty Acids That Inhibit Cancer: Conjugated Dienoic Derivatives of Linoleic Acid. The Usefulness of In Vitro Assays and Animal Experiments in the Design of Chemopreventive Protocols with Beta-Carotene and Vitamin A on Tobacco Chewers. Dietary Modulation of Tobacco-Specific Carcinogen Activation. Mechanisms of Specific Nutrients in the Prevention of Cancer. Preclinical Studies in Cancer Prevention and Treatment. Reduction of Ultraviolet-Induced Immunosuppression and Enhanced Resistance to Ultraviolet-Induced Tumors by Retinyl Palmitate and Canthaxanthin. Retinoids and Prevention of Experimental Cancer. Selenium and Vitamin E in Cancer Prevention. Vitamin B6 and Cancer. Clinical Studies in Cancer Prevention and Treatment. The Nutritional Causes of Large-Bowel Cancer: Data from the Melbourne Colorectal Cancer Study and a 25-Year World Literature Overview 1965-1989. An Intermediate Evaluation of the Nutrition Intervention Trials in Linxian China. Control of Human Preneoplasia with Retinoids and Other Compounds. Carotenoids in Cancer Chemoprevention and Synergism with Retinol in Mastalgia Treatment. Adjuvant Immunotherapy of Breast Cancer: Prototypic Observations with Alpha- Tocopherol and Retinol. Vitamin B-6 and B-1 Status During Hormone Therapy of Gynecological Cancer. Index.