Nucleosides and Nucleotides As Antitumor and Antiviral Agents

By: C.K. Chu (Editor), D.C. Baker (Editor)

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Hardcover | 1 July 1993

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352 Pages

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25.4 x 17.8 x 2.54

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Proceedings of an American Chemical Society Carbohydrate Division Symposium (Tohru Ueda Memorial Symposium), held in San Francisco, April 1992. Among the topics in 17 papers: lithiation chemistry of uridine derivatives access to a new anti-HIV-1 lead; approaches to novel isomeric nucleosides as anti

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Non-Fiction Science Biology, Life Sciences Biochemistry Cellular Biology Medicine Clinical & Internal Medicine Diseases & Disorders Infectious & Contagious Diseases Other Branches of Medicine Pharmacology Medicine in General

Chemistry Analytical Chemistry Nursing & Ancillary Services Pharmacy & Dispensing

Design of New Types of Antitumor Nucleosides: The Synthesis and Antitumor Activity of 2'-Deoxy-(2'-C-Substituted)Cytidines	p. 1
Lithiation Chemistry of Uridine Derivatives: Access to a New Anti-HIV-1 Lead	p. 23
A Synthesis of 2'-Fluoro- and 3'-Fluoro-Substituted Purine Nucleosides via A Direct Approach	p. 55
Allenols Derived from Nucleic Acid Bases - A New Class of Anti-HIV Agents: Chemistry and Biological Activity	p. 73
Structure-Activity Relationship among HIV Inhibitory 4'-Substituted Nucleosides	p. 101
Adenosine-Derived 5'-[alpha]-Halo Thioether, Sulfoxide, Sulfone, and (5'-Halo)Methylene Analogues:Inhibition of S-Adenosyl-L-Homocysteine Hydrolase	p. 115
Approaches to Novel Isomeric Nucleosides as Antiviral Agents	p. 127
Carbocyclic 7-Deazaguanosine Nucleosides as Antiviral Agents	p. 141
L-Ascorbic and D-Isoascorbic Acids: Chiron Sources for 1',2'-SECO-Nucleosides/tides, Phosphonates, and Other Molecules of Biological Interest	p. 159
Synthesis and Anticancer and Antiviral Activity of Certain Pyrimidine Nucleoside Analogues	p. 177
Structure-Activity Correlations of 2',3'-Dideoxy- and 2',3'-Didehydro-2',3'-Dideoxypyrimidine Nucleosides as Potential Anti-HIV Drugs	p. 203
Stereocontrolled Routes for the Synthesis of Anti-HIV and Anti-HBV Nucleosides	p. 219
5-Substituted Arabinofuranosyluracil Nucleosides as Antiherpesvirus Agents: From araT to BV-araU	p. 245
Conformational Studies and Anti-HIV Activity of Mono- and Difluorodideoxy Nucleosides	p. 265
Crystal Structures and Molecular Conformations of Anti-HIV Nucleosides	p. 285
Modified Oligoribonucleotides: Synthesis and Preliminary Evaluation of [alpha]-RNA	p. 303
Towards Second-Generation Synthetic Backbones for Antisense Oligonucleosides	p. 311
Index	p. 325
Table of Contents provided by Blackwell. All Rights Reserved.

Nucleosides and Nucleotides As Antitumor and Antiviral Agents

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