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Novel Inhibitors of Leukotrienes : Progress in Inflammation Research - Giancarlo Folco

Novel Inhibitors of Leukotrienes

Progress in Inflammation Research

By: Giancarlo Folco (Editor), Bengt Samuelsson (Editor), Robert C. Murphy (Editor)

Hardcover Published: 1st September 1999
ISBN: 9783764358846
Number Of Pages: 347

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Many new antileukotriene drugs are now marketed as antiasthma drugs and represent the first new drugs in this field since the 1970s. This book covers the steps that have led to the discovery and development of these new drugs and offers detailed descriptions of their clinical applications. The review chapters on the main aspects of basic and applied leukotriene research are written by leading specialists in the field, and the volume takes a new approach in presenting information of particular interest to both scientists and clinicians in the fields of asthma, inflammation and allergic diseases.

List of contributors
5-Lipoxygenasep. 1
LTC[subscript 4] synthase: A key enzyme in cysteinyl leukotriene formationp. 23
Leukotriene A[subscript 4] hydrolase: A key enzyme in chemotactic leukotriene formationp. 45
Metabolism of leukotrienes and formation of new leukotriene structuresp. 63
Receptors for cysteinyl-leukotrienes: Targets for new drugsp. 83
Targeted disruption of 5-lipoxygenasep. 101
Transcellular biosynthesis of leukotrienes: A unique mode of cell communicationp. 113
Physiological and pathophysiological activities of leukotrienesp. 125
Entry rate and metabolic handling of LTC[subscript 4] in the human circulationp. 139
Genetic polymorphisms of 5-LOp. 147
Leukotrienes and aspirin-intolerant asthmap. 165
Leukotrienes in nocturnal asthmap. 177
Leukotrienes and allergic asthmap. 185
Inhibitors of leukotrienes: An overviewp. 205
The development of zafirlukast (Accolate) and the Zeneca series of peptidyl-leukotriene receptor antagonistsp. 215
The development of zileuton (ZYFLO) and the N-hydroxyurea class of 5-lipoxygenase inhibitorsp. 235
The development of BAY X 1005 and the Bayer series of leukotriene biosythesis inhibitorsp. 251
The development of iralukast: A member of the Novartis series of cysteinyl leukotriene antagonistsp. 269
LTB[subscript 4] receptor antagonistsp. 299
SmithKline Beecham pharmaceuticals' cysteinyl leukotriene receptor antagonists: Pranlukast (SB 205312; Ono-1078; Onon), Pobilukast (SKandF 104353) and SKandF 106203p. 317
Indexp. 343
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9783764358846
ISBN-10: 376435884X
Series: Progress in Inflammation Research
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 347
Published: 1st September 1999
Publisher: Birkhauser Verlag AG
Country of Publication: CH
Dimensions (cm): 23.5 x 15.5  x 2.0
Weight (kg): 0.69