Novel Approaches to Selective Treatments of Human Solid Tumors : Laboratory and Clinical Correlation

By: Youcef M. Rustum (Editor)

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336 Pages

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25.4 x 17.78 x 1.91

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Proceedings of an international symposium held in Buffalo, N.Y., September 1992. With the major diseases of focus being advanced and adjuvant colorectal cancer, head and neck cancer, and breast cancers, the volume is divided into sections devoted to fluoropyrimidine metabolism and mechanism of actio

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You Can Find This Book In

Non-Fiction Medicine Clinical & Internal Medicine Diseases & Disorders Oncology Infectious & Contagious Diseases Science Biology, Life Sciences Life Sciences in General Genetics excluding Medical Other Branches of Medicine Pharmacology

Pre-Clinical Medicine & Basic Sciences Medical Genetics Botany & Plant Sciences Zoology & Animal Sciences

5-Fluoro-2'-Deoxyuridine: Role of Schedule in its Therapeutic Efficacy	p. 1
Comparison of Continuous Infusions and Bolus Injections of 5-Fluorouracil with or without Leucovorin: Implications for Inhibition of Thymidylate Synthase	p. 9
Cellular Interactions Between the Natural and Unnatural Isomers of 5-Formyltetrahydrofolate	p. 23
Leucovorin as a Prodrug	p. 31
Clinical Use of Leucovorin: Intracellular Metabolism	p. 43
Some Considerations Concerning the Dose and Schedule of 5FU and Leucovorin: Toxicities of Two Dose Schedules from the Intergroup Colon Adjuvant Trial (INT-0089)	p. 51
Effects of 5-Fluorouracil on mRNA	p. 57
Genetic Variation in Thymidylate Synthase Confers Resistance to 5-Fluorodeoxyuridine	p. 67
Experience with 5FU + L-Leucovorin	p. 77
5-Fluorouracil Combined with the Pure [6S]-Stereoisomer of Folinic Acid in High Doses for Treatment of Patients with Advanced Colorectal Carcinoma: A Phase I-II Study of Two Consecutive Regimens	p. 81
5-Fluorouracil Modulation in Colorectal Carcinoma: Experience of German Investigators	p. 99
An Overview of Adjuvant Treatment of Colon Cancer	p. 109
Dose-Dependent Inhibition of Aspartate Carbamoyltransferase in Peripheral Blood Mononuclear Cells in Patients Receiving N-(Phosphonacetyl)-L-Aspartate	p. 119
Increasing the Efficacy of 5-Fluorouracil with Interferons: Preclinical, Clinical, and Pharmacokinetic Studies	p. 125
Enchanced Cytotoxicity of 5-Fluorouracil Combined with [6RS]-Leucovorin and Recombinant Human Interferon-[alpha]2a in Colon Carcinoma Cells	p. 133
Regulation of Thymidylate Synthase in Human Colon Cancer Cells Treated with 5-Fluorouracil and Interferon-Gamma	p. 143
Biochemical Modulation of 5-Fluorouracil by PALA: Mechanism of Action	p. 153
Implications of Chronobiology for 5-Fluorouracil (5-FU) Efficacy	p. 169
Fluorouracil and Leucovorin in Advanced Breast Cancer	p. 187
Fluorouracil Modulation in Head and Neck Cancer	p. 197
Biomodulation in Head and Neck Carcinomas: Therapeutic Approaches in Europe	p. 209
Rationale for the Combination Therapy of 5FU and CDDP	p. 223
Biochemical Modulation of Fluoropyrimidines: The "Giscad" Studies	p. 233
Clinical Experience with UFT in Japan	p. 243
Clinical Studies of the Modulation of Ftorafur	p. 253
The Role of the Reduced-Folate Carrier and Metabolism to Intracellular Polyglutamates for the Activity of ICI D1694	p. 265
The History of the Development and Clinical Use of CB 3717 and ICI D1694	p. 277
P53: A Determinant of the Cell Cycle Response to DNA Damage	p. 291
Therapeutic Implications of Molecular Genetics	p. 297
Summary	p. 305
Abbreviations	p. 311
Author Index	p. 313
Subject Index	p. 315
Table of Contents provided by Blackwell. All Rights Reserved.

Novel Approaches to Selective Treatments of Human Solid Tumors : Laboratory and Clinical Correlation

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