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Normal and Malignant Liver Cell Growth : Falk Symposium - W. E. Fleig

Normal and Malignant Liver Cell Growth

Falk Symposium

By: W. E. Fleig (Editor)

Hardcover

Published: 31st December 1998
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Although cell turnover in normal adult liver is extremely low, hepatic tissue is notorious for its almost infinite capacity to regenerate in cases of viral, toxic or traumatic damage. Hepatocellular carcinoma is one of the most frequent malignancies worldwide and causes more than a million deaths per year. The mechanisms governing normal proliferation and malignant transformation of liver cells are of utmost interest for the understanding of regeneration and hepatocarcinogenesis and for the development of new therapeutic strategies. Therefore, the International Falk Workshop held in Halle, Germany, on January 29-30 1998, focused on the issues of normal and malignant liver cell growth. Knowledge in this area of research has expanded rapidly during recent years. This text of proceedings summarizes the latest advances both in basic science and clinical research. Stimulating discussion set the basis for the development of new strategies in diagnosis and treatment of hepatocellular carcinoma and for the manipulation of regeneration in cases of acute or chronic loss of functional liver tissue.

List of Principal Authorsp. viii
Prefacep. x
Liver Growth and Repair
Overview: Recent developments in liver growth--new pieces to the puzzlep. 3
Hepatocyte growth factor (HGF) and liver regenerationp. 27
A diversity of EGF-like ligands and receptors in liverp. 33
Cytokine regulation of liver regenerationp. 47
Initiation of liver regeneration by tumour necrosis factorp. 56
IL-6 and liver growth regulationp. 68
Mechanisms of liver-specific gene transcription during liver regenerationp. 75
Phenotypic plasticity of normal and neoplastic rat liver epithelial stem-like cells: implications for identifying liver stem cells in vivop. 95
Fetal hepatocytes differentiate along the hepatocyte and biliary lineages following hepatic transplantationp. 111
Immunohistochemical properties of putative human hepatic epithelial stem cellsp. 118
Hepatocarcinogenesis and Hepatocellular Carcinoma
Analysis of genetic events during mouse hepatocarcinogenesis in transgenic modelsp. 127
The role of apoptosis in hepatocarcinogenesisp. 128
Multifaceted M6P/IGF2R liver tumour suppressorp. 136
The ductular reaction in liver disease - emphasis on a type I responsep. 141
Abrogation of negative growth regulatory pathways by hepatitis B virus encoded x antigen in the development of hepatocellular carcinomap. 156
Genetic and functional analysis of the effects of hepatitis B viral transactivator HBx on cell growth and apoptosis: implications for viral replication and hepatocarcinogenesis
Hepatitis C virus and hepatocellular carcinomap. 187
Risk factors for hepatocellular carcinoma in cirrhosisp. 190
Interventional treatment of hepatocellular carcinomap. 204
Liver transplantation vs liver resection for hepatocellular carcinomap. 213
Gene therapy for hepatocellular carcinoma: concepts and perspectivesp. 232
Indexp. 243
Table of Contents provided by Syndetics. All Rights Reserved.

ISBN: 9780792387480
ISBN-10: 0792387481
Series: Falk Symposium
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 248
Published: 31st December 1998
Publisher: Springer
Country of Publication: NL
Dimensions (cm): 25.4 x 17.8  x 1.5
Weight (kg): 1.22