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Non-dopamine Lesions in Parkinson's Disease - PhD, Glenda Halliday

Non-dopamine Lesions in Parkinson's Disease

Hardcover Published: 30th November 2010
ISBN: 9780195371086
Number Of Pages: 336

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Parkinson's disease becomes apparent only after substantial loss (>60%) of the dopamine neurons in the substantia nigra. By this time there has already been widespread neural inclusion formation in the peripheral and central nervous system of patients with the disease, although this has only been recognized more recently. Degeneration in these widespread regions of the peripheral and central nervous system is now known to impact on disease symptoms, progression and treatment over time. This book aims to provide a comprehensive review of these non-dopamine lesions in Parkinson's disease by assessing our current knowledge of their presence and pathophysiology, how they relate to different symptoms and, where relevant, discuss how they may be potentially treated. The book addresses most of the known symptoms that occur in patients with Parkinson's disease. In addition to the classic motor triad, motor speech, eye movements, olfactory dysfunction, autonomic dysfunction, pain and sensory abnormalities, sleep disturbances, depression and apathy, dopamine dysregulation syndromes, hallucinations and psychoses, cognitive impairment and dementia, and systemic manifestations are all reviewed. Early selective cell loss in non-dopaminergic regions is highlighted (the glutamate projection neurons of the presupplementary motor cortex and caudal intralaminar thalamus) in addition to the widespread inclusion formation in many regions outside the basal ganglia that characterize the disease. Overall this book provides a comprehensive analysis of the lesions associated with the most common symptoms found in patients with Parkinson's disease.

It is becoming increasingly clear that the clinically heterogenous presentation of Parkinson's "Disease reflects compromise of both dopaminergic and non-dopaminergic systems...A more complete understanding of Parkinson's Disease mandates an in-depth exploration of the many other compromised neural systems. The contributions edited by Drs. Halliday, Barker, and Rowe have succeeded remarkably---. But more significantly, each chapter provides a cogent and succinct discussion of the relevant basic as well as applied physiology for each compromised system, and can serve as an up-to-date primer of translational clinical neurophysiology for practicing as well as academic Neurologists. This is an outstanding one-of-a-kind book, and a must read." - Stanley H. Appel MD, Peggy and Gary Edwards Distinguished Endowed Chair for the Treatment and Research of ALS, Chair, Dept of Neurology, Methodist Neurological Institute, Houston, TX "This interesting book...focuses upon a range of Parkinson's disease-related symptoms widely believed to have a non-dopaminergic basis. Such symptoms are almost exclusively "non-motor" in nature. It is thus highly topical, as our awareness of non-motor symptoms is increasing, together with the impact such symptoms have on the patient and their families. The book deals with non-motor symptoms in a systematic and in depth way, with a strong emphasis on the neuroanatomical and pathophysiological basis of the symptoms that will be welcomed by those wishing to acquire a more detailed understanding of the problems. The book... will be best appreciated by the reader with extant basic knowledge, aiming to move to a higher level of understanding." - David J Burn, Professor of Movement Disorders Neurology & Honorary Consultant Neurologist, Clinical Ageing Research Unit, Newcastle University Campus for Ageing and Vitality, Newcastle upon Tyne, UK

TABLE OF CONTENTS Contributors Chapter 1: Lesions Associated with the Classic Triad of Parkinsonian Motor Features Stanley Fahn and Glenda M. Halliday Chapter 2: Lesions Associated with Motor Speech Anna Rita Bentivoglio, Davide Quaranta, and Aileen K. Ho Chapter 3: Lesions Associated with Eye Movements Andrew W. Michell, Roger A. Barker, and Glenda M. Halliday Chapter 4: Olfactory Dysfunction in Parkinson's Disease and Related Disorders Richard L. Doty, Christopher Hawkes, and Henk W. Berendse Chapter 5: Lesions Associated with Autonomic Dysfunction A: Swallowing Disorders and Drooling Maria G. Cersosimo and Eduardo E. Bennarroch B: Gastrointestinal Disorders Adolfo Mínguez-Castellanos and Dominic B. Rowe C: Orthostatic Hypotension Spiridon Papapetropoulos and Kathryn K. Post Chapter 6: Lesions Associated with Pain and Sensory Abnormalities Andreas Hartmann and Glenda M. Halliday Chapter 7: Lesions Associated with Sleep Disturbances Marcus M. Unger, Wolfgang H. Oertel, Thomas C. Thannickal, Yuan-Yang Lai, and Jerome M. Siegel Chapter 8: Lesions Associated with Depression and Apathy Uwe Ehrt, Kenn F. Pedersen, and Dag Aarsland Chapter 9: Lesions Associated with Dyskinesias and the Dopamine Dysregulation Syndrome Andrew H. Evans Chapter 10: Lesions Associated with Visual Hallucinations and Psychoses David R. Williams and Werner Poewe Chapter 11: Lesions Associated with Cognitive Impairment and Dementia Jonathan Evans, Tamas Revesz, and Roger A. Barker Chapter 12: Systemic Manifestations of Parkinson's Disease Dominic B. Rowe Index

ISBN: 9780195371086
ISBN-10: 0195371089
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 336
Published: 30th November 2010
Publisher: Oxford University Press Inc
Country of Publication: US
Dimensions (cm): 24.1 x 17.1  x 2.4
Weight (kg): 0.81