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Nitric Oxide in Transplant Rejection and Anti-Tumor Defense - Stanislaw Lukiewicz

Nitric Oxide in Transplant Rejection and Anti-Tumor Defense

By: Stanislaw Lukiewicz (Editor), Jay L. Zweier (Editor)

Hardcover Published: December 2009
ISBN: 9780792383895
Number Of Pages: 376

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Nitric Oxide in Transplant Rejection and Anti-Tumor Defense represents a unique combination of three interrelated topics that is unavailable in any other single work: The detection and visualization of nitric oxide in biological materials using EPR spectroscopy and EPR imaging; Nitric oxide in immune mechanisms of allograft rejection; and The involvement of nitric oxide in anti-tumor defense. By bringing together specialists from these three disciplines, the book investigates the common molecular and cellular mechanisms underlying phenomena in transplants and oncology. In addition, the book provides an introduction to biological applications of EPR spectroscopy and imaging. Nitric Oxide in Transplant Rejection and Anti-Tumor Defense will appeal to researchers and graduate-level students investigating transplant rejections and their immune mechanisms, anti-tumor immune defenses, novel types of contrast agents for EPR imaging, and biological applications of EPR spectroscopy and EPR imaging.

Prefacep. xi
Acknowledgmentp. xiii
Electron Paramagetic Resonance Spectroscopy and Imaging as Research Tools
Epr Detection of Nitrosylated Compounds: Introduction with Some Historical Background
Sources of Nitric Oxidep. 3
Paramagnetism of NO and of Nitrosylated Metalsp. 7
Spin-Trapping Methodsp. 15
Comparative Quantification Methods of Nitric Oxidep. 17
Conclusionp. 19
Referencesp. 20
Principles of Epr Spectroscopy for Measurement of Free Radicals in Biological Tissues
Introductionp. 37
Backgroundp. 38
Conclusionp. 47
Referencesp. 47
Epr Studies and Biological Implications of Nitrosyl Nonheme Iron Complexes
Introductionp. 49
DNIC in Cells and Tissuesp. 50
Fe-Dithiocarbamates as NO Trapsp. 60
Biological Activity of Model DNICp. 70
Conclusionp. 71
Referencesp. 72
Enzyme Independent Formation of Nitric Oxide in Tissues
Introductionp. 83
EPR Measurement of Nitric Oxidep. 84
Isotope Tracer Measurements of Nitrix Oxide Formationp. 86
Measurement of Nitrite in Heart Tissuep. 87
Correlation of Intracellular Ph and Nitrix Oxide Formationp. 88
Role of Nitrix Oxide Generation in Functional Injuryp. 89
Conclusionp. 91
Referencesp. 92
Spin-Label No-Metry in Lipid Bilayer Membranes
Introductionp. 95
Experimental Approachesp. 97
Nitric Oxide Transport in Membranesp. 100
Conclusionp. 105
Referencesp. 105
Epr Imaging of Free Radicals in Biological Systems
Introductionp. 109
Principlep. 110
NMR Imaging vs EPR Imagingp. 110
Spatial and Spectral-spatial Imagingp. 111
Low-Frequency EPR Imaging Instrumentationp. 111
Resonators for EPR Imagingp. 112
Imaging of Biological Samplesp. 112
3D Spectra-Spatial Imagingp. 113
3D Spatial Imagingp. 114
Gated 3D Spatial Imagingp. 115
Conclusionp. 116
Referencesp. 117
Electron Paramagnetic Resonance Imaging of Nitric Oxide in Tissues
Introductionp. 119
EPR Imaging Methodologyp. 121
Imaging of Nitric Oxidep. 123
Analysis of Images of Nitric Oxidep. 129
Conclusionp. 132
Referencesp. 132
Allo- and Xenograft Rejection
Allograft Rejection: Fact and Fancy
Introductionp. 137
Patterns of Rejectionp. 138
Graft Immunogenicityp. 139
The Systemic Nature of Allograft Rejectionp. 140
Cellular Effector Activityp. 141
Mediatorsp. 142
Return to Immunological Homeostasisp. 142
Conclusionp. 143
Referencesp. 143
Immunobiology of Transplants: Specific and Nonspecific Mechanisms Involved in Allograft Rejection
Introductionp. 145
Specific Mechanisms Involved in Response to Alloantigensp. 146
Nonspecific Mechanisms Involved in Organ Transplant Damagep. 147
Prevention of Allograft Damage Inflicted by NO and Free Radicalsp. 150
Effect of Modalities Blocking Adhesion Molecule Expression on Ischemic/Reperfusion Injuryp. 151
Conclusionp. 153
Referencesp. 153
Animal EPR Studies on Allo- and Xenograft Rejection
Introductionp. 157
Historical Backgroundp. 159
Kinetic EPR Approach to Transplant Rejectionp. 160
Experimental Models in Transplantological EPR Studiesp. 168
Conclusionp. 179
Referencesp. 181
Nitric Oxide Effects on Murine Cardiac Allografts
Introductionp. 189
EPR Studies of Cardiac Allograft Rejection in a Murine Modelp. 190
The Origin of Heme-Nitrosyl EPR Signalsp. 195
Conclusionp. 200
Referencesp. 200
Accelarated Rejection of Cardiac Allo- and Xenografts in Pre-Sensitized Rats and Gerbils
Introductionp. 205
EPR Experimental Studies on Allo- and Xenograft Rejectionp. 206
Conclusionp. 210
Referencesp. 211
Involvement of Nitric Oxide in Amphibian Transplantation Immunity
Introductionp. 213
NO Involvement in Mammalian Transplantation Immunityp. 214
Amphibian Model of Transplantation Immunityp. 214
Conclusionp. 222
Referencesp. 222
Antitumor Immune Responses
Interactions Between Cytokine Induced Nitric Oxide and Intracellular Ironp. 229
Conclusionp. 233
Referencesp. 234
Molecules Involved in the Recruitment and Regulation of Tumor-Associated Macrophages
Introductionp. 239
MCP-1, A Tumor-Derived Chemotactic Cytokinep. 240
Tumor Cells as a Source of Chemokines In Vivop. 241
Signal Transductionp. 242
Spectrum of Actionp. 244
Role in Pathologyp. 246
Conclusionp. 246
Referencesp. 246
The Role of Macrophage-Derived Nitric Oxide in Tumor Cell Death
Introductionp. 253
The Macrophage as an Antitumor Effector Cell: A Historical Overviewp. 253
Macrophage-Derived NO as a Mediator of Tumor Killing and Cytostasisp. 254
The Selective Nature of NO-Dependent Tumor Killingp. 257
Conclusionp. 262
Referencesp. 262
Transcriptional Regulation of the Macrophage NOS2 Gene
Introductionp. 267
Experimental analysis of NOS2 Transcriptionp. 269
Conclusionp. 274
Referencesp. 275
Infection, Inflammation and Cancer Mediated by Oxygen Radicals and Nitric Oxide
Introductionp. 277
Virus Infections and Free Radical Generationp. 279
Generation of Nitrix Oxide in Virus Infectionp. 283
Bacterial Infection and Generation of Free Radicalsp. 286
Tumor Growth Enhanced by Nitric Oxidep. 289
General Considerationsp. 289
Conclusionp. 290
Referencesp. 291
Induction of Iron-Nitric Oxide EPR Signals in Murine Cancers: Effects of Thiols and Cytokine-Induced Oxidant Stress
Introductionp. 295
Effect of IL-2 Therapy on Human Tumorsp. 296
Effect of IL-2 Therapy on Murine Tumorsp. 297
Effect of BSO on Cultured Tumor Cellsp. 305
Conclusionp. 308
Referencesp. 309
EPR Analysis of Tumor-Host Interactions
Introductionp. 313
EPR Spectra of Animal Tissuesp. 314
Experimental Modifications of Tumor-Host Relationsp. 318
Prognostic Value of EPR Triplet Signals in Tumorsp. 322
Conclusionp. 324
Referencesp. 325
Ambivalent Role for no in the Antitumor Immune Response
Introductionp. 327
Experimental Analysis of Nitric Oxide Function in Tumor Development and Regressionp. 328
Working Hypothesisp. 337
Conclusionp. 338
Referencesp. 339
Identification of Nitric Oxide-Derived EPR Signals in Human Cancers
Introductionp. 341
Nitric Oxide Derived EPR Signals in Murine Tumorsp. 342
EPR Analysis of Human Cancersp. 343
Implications of Human EPR Datap. 344
Conclusionp. 349
Referencesp. 349
EPR Signals Detectable in Human Tumors
Introductionp. 353
Methodical Approachesp. 354
EPR Triplet Signals Detected in Human Tumorsp. 359
EPR Signals of Ceruloplasmin and Related Compoundsp. 362
Conclusionp. 368
Referencesp. 368
Subject Indexp. 371
Table of Contents provided by Syndetics. All Rights Reserved.

ISBN: 9780792383895
ISBN-10: 0792383893
Audience: General
Format: Hardcover
Language: English
Number Of Pages: 376
Published: December 2009
Country of Publication: US
Dimensions (cm): 23.39 x 15.6  x 2.24
Weight (kg): 0.72