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Next Generation Antidepressants : Moving Beyond Monoamines to Discover Novel Treatment Strategies for Mood Disorders - Chad E. Beyer

Next Generation Antidepressants

Moving Beyond Monoamines to Discover Novel Treatment Strategies for Mood Disorders

By: Chad E. Beyer (Editor), Stephen M. Stahl (Editor)

Hardcover

Published: 28th June 2010
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The World Health Organization defines depression as a primary contributor to the global burden of disease and predicts it will become the second leading cause of death by 2020. The need to develop effective therapies has never been so pressing. Current antidepressant drugs have several limitations. This 2010 book looks at the future of mood-disorder research, covering the identification of new therapeutic targets, establishing new preclinical models, new medicinal chemistry opportunities, and fostering greater understanding of genetic influences. These strategies are likely to help build a better picture of the disease process, and lead to new opportunities for patient stratification and treatment. The ultimate goal for this strand of research is to develop more personalized and effective treatments for this chronic and debilitating condition. This is essential reading for all those involved in psychopharmacologic drug development, and mental health clinicians seeking a preview of discoveries soon to influence their practice.

'This is a very useful and interesting publication with a great deal of clearly summarised information on biological depression research. It gives a concise overview of likely future directions for new treatments.' The British Journal of Psychiatry

Preface
Current depression landscape: a state of the field today
Novel therapeutic targets for treating affective disorders
Developing novel animal models of depression
Translational research in mood disorders: using imaging technologies in biomarker research
Defining depression endophenotypes
Genetic and genomic studies of major depressive disorder
Medicinal chemistry challenges in the design of next generation antidepressants
Application of pharmacogenomics and personalized medicine for the care of depression
Index
Table of Contents provided by Publisher. All Rights Reserved.

ISBN: 9780521760584
ISBN-10: 0521760585
Series: Cambridge Medicine (Hardcover)
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 150
Published: 28th June 2010
Publisher: CAMBRIDGE UNIV PR
Country of Publication: GB
Dimensions (cm): 24.0 x 16.2  x 1.7
Weight (kg): 0.46