New Concepts in the Pathogenesis of NIDDM

By: Claes-Goran Ostenson (Editor)

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332 Pages

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Two dozen papers present theories on the molecular and genetic mechanisms responsible for the development of glucose intolerance in non-insulin-dependent diabetes mellitus. They cover the regulation of insulin secretion; insulin, insulin receptors, and glucose transporters; insulin action; gluconeog

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You Can Find This Book In

Non-Fiction Medicine Clinical & Internal Medicine Endocrinology Family & Health Popular Medicine & Health Science Biology, Life Sciences Biochemistry Pre-Clinical Medicine & Basic Sciences Physiology Metabolism

Coping with / Advice about Personal, Social & Health Topics Coping with / Advice about Illness & Specific Health Conditions Botany & Plant Sciences Zoology & Animal Sciences

Impaired Glucose-Induced Insulin Secretion: Studies in Animal Models with Spontaneous NIDDM	p. 1
Perturbation of Islet Metabolism and Insulin Release in NIDDM	p. 13
Regulation of Cytoplasmic Free Ca[superscript 2+] in Insulin-Secreting Cells	p. 25
The [Beta]-Cell Sulfonylurea Receptor	p. 47
Regulation of Glucose Transporters and the Na/K-ATPase by Insulin in Skeletal Muscle	p. 63
Insulin Receptor: Aspects of Its Structure and Function	p. 79
The Diabetogenes Concept of NIDDM	p. 89
Molecular Genetics of NIDDM and the Genes for Insulin and Insulin Receptor	p. 101
Autoregulation of Glucose Transport: Effects of Glucose on Glucose Transporter Expression and Cellular Location in Muscle	p. 113
Insulin Resistance and the Pathogenesis of Non-Insulin Dependent Diabetes Mellitus: Cellular and Molecular Mechanisms	p. 129
Indirect Effects of Insulin in Regulating Glucose Fluxes	p. 151
The Insulin-Antagonistic Effect of the Counterregulatory Hormones - Clinical and Mechanistic Aspects	p. 169
On Insulin Action in Vivo: The Single Gateway Hypothesis	p. 181
Acute Hormonal Regulation of Gluconeogenesis in the Conscious Dog	p. 199
Estimating Gluconeogenic Rates in NIDDM	p. 209
Glucose Metabolism during Physical Exercise in Patients with Noninsulin-Dependent (Type II) Diabetes	p. 221
Substrates and the Regulation of Hepatic Glycogen Metabolism	p. 235
Gluconeogenesis in Type 2 Diabetes	p. 253
Regulation of Adipose Tissue Lipolysis, Importance for the Metabolic Syndrome	p. 259
Cellular and Molecular Factors in Adipose Tissue Growth and Obesity	p. 269
Regional Obesity and NIDDM	p. 279
Hyperinsulinemia and VLDL Kinetics	p. 287
Hyperinsulinism and Dyslipidemias as Coronary Heart Disease Risk Factors in NIDDM	p. 295
A Paradigm to Link Clinical Research to Clinical Practice: The Challenge in Non-Insulin Dependent Diabetes Mellitus	p. 303
Index	p. 311
Table of Contents provided by Blackwell. All Rights Reserved.

New Concepts in the Pathogenesis of NIDDM

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