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Neurotoxic Factors in Parkinson's Disease and Related Disorders - Alexander Storch

Neurotoxic Factors in Parkinson's Disease and Related Disorders

By: Alexander Storch (Editor), Michael A. Collins (Editor)

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Published: 31st January 2001
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nd This book stems from the 2 Parkinson's Disease Symposium on "Neurotoxic Factors in Parkinsons disease and related disorders", held on August 6-7,1999 at the University ofUlm Medical School in Ulm at the Danube, Germany. The symposium wasalso asatellite ofthejointmeetingofthe InternationalSocietyfor Neurochemistry (ISN) and the European Society for Neurochemistry (ESN) that followed immediately afterwards in Berlin. The specific topic, neurotoxic factors in Parkinson's disease (PD), was chosen in light of accumulating neurobiological and epidemiological evidence indicating that the causes of this second most common neurodegenerative disorder, and possibly of related conditions such as multiple systems atrophy, in some manner involve environĀ­ mental (xenobiotic) and even endogenous toxic agents. This volume brings together much of that neurobiological evidence; and in epidemiology, several recent major studies ofPD - for example, a study of20,000 twins published in the Journal of the American Medical Association in 1999 - conclude that environmental and life style than genetics, appear to be critical in the idiopathic disease. However, factors, rather the precise roles of neurotoxic factors in the pathogenesis of PD and related basal ganglia disorders remain uncertain, despite the cascade of research resulting from the discovery of the prototype MPTP in the early 1980's, and frankly, we have been surprised by the paucity of concentrated attention on specific environmental agents other than MPTP.

Mechanisms of Selective Vulnerability
Mechanisms of Selective Toxicity in Neurodegenerative Disordersp. 1
The Dopamine Transporter: Involvement in Selective Dopaminergic Neurodegenerationp. 17
MPTP/MPP[superscript +] Action and Mechanism
Advances in Our Knowledge of MPTP Action and Mechanismp. 41
Role of Microtubules in the Genesis of MPTP Neurotoxicityp. 55
Complex I Inhibition in Cultured Cells as Model for Parkinson's Diseasep. 59
Nigral Degeneration in Animal Models of Multiple System Atrophyp. 65
Isoquinolines as Potential Neurotoxins
Isoquinoline Neurotoxinsp. 69
Apoptosis by an Endogenous Neurotoxin, N-Methyl(R)Salsolinol: Relevance to Parkinson's Diseasep. 77
Isoquinolines in Parkinson's Diseasep. 91
Systematic Studies of Dopamine and Dopamine-Derived Salsolinol and Norsalsolinol Levels in Various Human Brain Areasp. 101
Antidopaminergic Effects of Putative Endogenous MPTP-Like Agents: 1,2,3,4-Tetrahydroisoquinoline and 1-Methyl-6,7-Dihydroxy-1,2,3,4-Tetrahydroisoquinolinep. 105
Development of an HPLC-Method and Synthesis of 1,2,3,4-Tetrahydroisoquinolines as Reference Compounds for the Identification of Possible Neurotoxins in the Blood of Parkinson's Disease Patientsp. 111
[beta]-Carbolines as Potential Neurotoxins
[beta]-Carboline Analogues of MPP[superscript +] as Environmental Neurotoxinsp. 115
N-Methyl-[beta]-Carbolinium Neurotoxins in Parkinson's Diseasep. 131
'TaClo', A Chloral-Derived Mammalian Alkaloid with Neurotoxic Propertiesp. 145
Nutritional Sources of Novel Tetrahydro-[beta]-Carbolinesp. 151
Catecholamine-Oxidation Pathways in Neurotoxicity
Endogenous Brain Catechol Thioethers in Dopaminergic Neurodegenerationp. 155
Catecholamine-Derived Aldehyde Neurotoxinsp. 167
Potential Roles of Accelerated Dopamine Oxidation, Altered Glutathione Metabolism, 5-S-Cysteinyl-Dopamine and Its Oxidative Metabolites in the Pathogenesis of Parkinson's Diseasep. 181
Neuromelanin May Mediate Neurotoxicity via its Interaction with Redox Active Ironp. 211
bcl-2 Protects SK-N-SH Cells from 6-Hydroxydopamine-Induced Apoptosis by Inhibition of Cytochrome c Redistributionp. 219
Generation of Neurotoxins by New Reaction Pathways of Dopamine under Oxidative Stress Conditions: Contributing Etiopathological Factors in Parkinson's Diseasep. 233
Pesticides and Metals in Nigrostriatal Degeneration
Relationship of Organochlorine Pesticides to Parkinsonismp. 237
Paraquat is a Model Environmental Neurotoxin for Studying Parkinson's Diseasep. 247
Brain Iron and Other Trace Metals in Neurodegenerative Diseasesp. 259
Mechanisms of Neuroprotection
Contribution of Intracellular Non-Haem Iron, NF-[kappa]B Activation and Inflammatory Responses to Neurodegeneration in Parkinson's Disease: Prospects for Neuroprotectionp. 277
Neurochemical Mechanisms Underlying Neuroprotective Actions of Bromocriptine, Salicylate, D- and L-Deprenyl in Neurodegeneration Caused by MPTPp. 289
Attenuation of Levodopa-Induced Toxicity in Primary Dopamine Neurons by Catechol-O-Methyltransferase Inhibitionp. 295
Unilateral 6-Hydroxydopamine Lesions of Nigrostriatal Dopaminergic Neurons Increased Cannabinoid CB[subscript 1] Receptor mRNA Levels in the Rat Striatum: Possible Therapeutic Implicationsp. 301
Poster Abstracts
Riluzole as a Neuroprotective Therapy in Animal Models of Parkinson's Diseasep. 309
Progressive Reduction of the Rat Nigrostriatal Dopamine Metabolism Induced by Iron-III and TaClop. 310
Brain N-Methylation of Indolic [beta]-Carbolines in Parkinsonismp. 311
Deleterious Effects of Highly Halogenated [beta]-Carbolines on Dopaminergic Cells in Culture and on Mitochondrial Respirationp. 312
Neuroprotective Role of Endogenous Adenosine in Methamphetamine-Induced Toxicity in Rat Striatump. 313
New Taurine Analogues in Treatment Strategies for Parkinson's Diseasep. 315
The Neurotoxicity of Manganesep. 316
Organotypic Striatal Slices: Neuroprotective Effects of Vitaminsp. 317
Impairment of Energy Metabolism is Not Responsible for Cytotoxicity of 6-Hydroxydopamine towards Human SH-SY5Y Dopaminergic Neuroblastoma Cellsp. 318
Development of a Sensitive and Selective GC/MS Method for the Determination of Tetrahydro-[beta]-Carbolines in Urine Samples. Occurrence of Some of these Compounds in the Urine of Parkinson's Disease Patientsp. 319
Chronic Treatment with 1,2,3,4-Tetrahydroisoquinoline (TIQ), an Environmental and Endogenous Substance, Induces Parkinsonian-Like Muscle Rigidity in Young and Old Ratsp. 320
Propargylamines Protect Dopamine Cells from Apoptosis Induced by a Neurotoxin, N-Methyl(R) Salsolinolp. 321
1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine and 1-Methyl-4-Phenylpyridinium Ions have Opposite Effects on Membrane Currents of Cultured Dorsal Root Ganglia Neuronsp. 322
The Effects of Catecholic and O-methylated Tetrahydroisoquinolines on the Production of Hydroxyl Radicalp. 323
Differential Cytotoxicity of Isoquinolines in HEK-293 Cells Stably Transfected with the Dopamine Transporter Genep. 324
HEK-293 Cells Expressing the Human Dopamine Transporter Are Susceptible to Low Concentrations of 1-Methyl-4-Phenylpyridinium (MPP[superscript +]) via Impairment of Energy Metabolismp. 325
Opposite Effects of Simple Tetrahydroisoquinolines on Amphetamine and Morphine-Stimulated Locomotor Activity in Micep. 326
Neurological Disorders--Acetylcholine Mimics and Their Role as Uncompetitive Inhibitors of Esterasesp. 327
Nicotinic Acetylcholine Receptor Agonist Activity of Isoquinoline Alkaloidsp. 328
Effects of TaClo (1-Trichloromethyl-1,2,3,4-Tetrahydro-[beta]-Carboline) on Mice Neuronal Culture and Possibilities of Cellular Regeneration In Vitro after Toxin Withdrawalp. 329
Indexp. 331
Index of Contributorsp. 339
Table of Contents provided by Syndetics. All Rights Reserved.

ISBN: 9780306465291
ISBN-10: 0306465299
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 340
Published: 31st January 2001
Publisher: Springer Science+Business Media
Country of Publication: US
Dimensions (cm): 25.4 x 17.8  x 1.91
Weight (kg): 1.5