1 Introduction - The Brain and the Biopsychosocial Approach to Medicine.- I Central Neurotransmitter Systems: Distribution and Function.- 2 Brain Monoaminergic Neurons: Distribution and Function in Relation to Regulation of Autonomic, Neuroendocrine and Immune Systems.- 3 Distribution and Function of Amino Acid Neurotransmitters: Roles in Central Modulation of the Autonomic, Neuroendocrine and Immune Systems.- 4 Neuropeptides and Their Possible Role as Auxiliary Messengers.- 5 Plasticity of Neuronal Interactions: Monoamines and Neuropeptides.- II The Autonomic System.- 6 An Overview of the Efferent Autonomic Nervous System.- 7 Brain Stem Mechanisms Regulating the Tonic and Reflex Control of Blood Pressure.- 8 Opiods and Other Neuropeptides: Functional Interactions with Autonomic Systems.- 9 Assessment of Autonomic Function in Essential Hypertension.- 10 The Importance of Autonomic Innervation of the Heart in the Genesis of Cardiac Arrhythmias.- III The Neuroendocrine System.- 11 The Neuroendocrine System.- 12 Monoaminergic Control of the Neuroendocrine System.- 13 Thyrotropin-Releasing Hormone: Localization of Specific Hypothalamic and Extrahypothalamic Sites of CNS Modulation.- 14 Neurohumoral Mechanisms in Asthma.- IV The Immune System.- 15 An Overview of the Immune Response or An Immunologist's View of the Nervous System Control of the Immune System.- 16 Interactions Among the Nervous, Endocrine and Immune Systems (NIM).- 17 Stress, Opioid Peptides and Immune Function.- 18 Stress, Depression and Immunity.- V The Central Nervous System and Disease.- 19 Overview of Central Control Mechanisms and Disease Development.- 20 Biosynthesis and Targeting of ?-Endorphin.- 21 Endorphins-Development of the Therapeutic Utility of Enkephalin Analogues.- 22 A Hypersensitive Serotonergic Receptor Theory of Depression: The Role of Stress.- 23 Neuropeptides and other Mediators in the Central Nervous System.- VI Short Communications.- 24 Glutamate, GABA and Cholinergic Systems in the NTS, DMN and Hypoglossal Nucleus of the Rat.- 25 Single Unit Responses to Catecholamines in the Nucleus Tractus Solitarii and Dorsal Motor Nucleus of the Vagus.- 26 In Vivo Cardiovascular Responses to Isoproterenol, Dopamine and Tyramine Following Prolonged Infusion of Isoproterenol.- 27 Cardiac Arrhythmia in Sleep Apnea Syndromes: State, Sinus Arrhythmia, and Concurrent Pathophysiology.- 28 Does Mental Stress Lead to Permanent Vascular Alterations?.- 29 Immobilisation Stress in Rats: Gastric Mucosal Depletion and Effects of Central Noradrenaline Depletion.- 30 Glucagon and Glucagon-Like Peptide Receptor Localization and Characterization in Rat Brain and Pituitary.- 31 Appetitive Behavior May Serve as a Model for Studying the Neural Facilitation and Inhibition of Plasma Corticosterone Levels in Rats.- 32 Suspense Increases Salivary Cortisol.- 33 Corticosterone Responses in Maternal and Neonatal Plasma Induced by Tryptophan Diets Fed During the Third Trimester.- 34 Influence of ?-Endorphin on the Antigen-Induced PFC Response of Human Blood B Lymphocytes in vitro.- 35 Interaction Between the Central Nervous System and the Immune System: The Influence of a Short and Mild Emotional Stress on the Proliferative Response of Rat Spleen Cells.- 36 In Vivo Voltammetric Evidence that d-Amphetamine and Phenethylamine Release Ascorbic Acid Into Striatal Extracellular Fluid.- 37 Serotonin, Imipramine Binding, Cortisol and Anxiety in Humans Under Stress.- 38 Bioavailability of the Opioid Peptide, Metkephamid.- 39 The Opioid Antagonist, ?-Funaltrexamine (?-FNA) Differentially Antagonizes the Analgesic Activity of Morphine and Metkephamid (LY127623), A Methionine-Enkephalin Analog.- 40 Temperature and Feeding Responses of Normal and Dystrophic Hamsters to Morphine.