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Neuroprotective Agents and Cerebral Ischaemia : Volume 40 - Ronald J. Bradley

Neuroprotective Agents and Cerebral Ischaemia

Volume 40

By: Ronald J. Bradley (Editor), Robert Adron Harris (Editor), Peter Jenner (Editor), Richard Green (Editor), Alan Cross (Editor)

Hardcover Published: 26th November 1996
ISBN: 9780123668400
Number Of Pages: 378

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General Description of Series
Since 1959, International Review of Neurobiology has been a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. This important serial is now being combined with Neuroscience Perspectives and Methods in Neurosciences. This combination results in a series that reaches a wider audience and publishes a greater number of thematic volumes.
General Description of Volume
Stroke is the third major cause of death in the western world, and recent data provide hope that treatments may soon be available. Written by world experts on the mechanisms involved in neurodegeneration, Neuroprotective Agents and Cerebral Ischaemia presents an up-to-date review of current research and developing therapies. This book is essential reading for all clinicians and researchers searching for neuroprotective drugs.
Key Features
* Describes the mechanisms involved in cell death and the biochemical changes occurring during an ischaemic episode
* Presents the different factors affecting the neurodegenerative process and how compounds acting on these systems may lead to novel neuroprotective agents
* Reviews "in vitro" and "in vivo" models of stroke and the activity of putative neuroprotective drugs
* Discusses the application of preclinical data to formulate approaches to a clinical problem
* Provides detailed reviews of both completed clinical trials and those currently underway

"In balance, I recommend this book as a superior volume, whose high 'power-to-weight ratio,' readability, and availability in paperback make it attractive for personal use." --TRENDS IN NEUROSCIENCES

Mechanisms of Nerve Cell Death: Apoptosis or Necrosis after Cerebral Ischaemia
Changes in Ionic Fluxes during Cerebral Ischaemia
Techniques for Examining Neuroprotective Drugs in Vivo
Techniques for Assessing Neuroprotective Drugs in Vitro
Calcium Antagonists: Their Role in Neuroprotection
Sodium and Potassium Channel Modulators: Their Role in Neuroprotection
NMDA Antagonists: Their Role in Neuroprotection
Development of the NMDA Ion-Channel Blocker Aptiganel Hydrochloride as a Neuroprotective Agent for Acute CNS Injury
Pharmacology of AMPA Antagonists and their Role in Neuroprotection
GABA and Neuroprotection
Adenosine and Neuroprotection
Interleukins and Cerebral Ischaemia
Nitrone-Based Free Radical Traps as Neuroprotective Agents in Cerebral Ischaemia and other Pathologies
Neurotoxic and Neuroprotective Roles of Nitric Oxide in Cerebral Ischaemia
A Review of Earlier Clinical Studies on Neuroprotective Agents and Current Approaches
Index
Table of Contents provided by Publisher. All Rights Reserved.

ISBN: 9780123668400
ISBN-10: 0123668409
Series: International Review of Neurobiology : Book 40
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 378
Published: 26th November 1996
Publisher: Elsevier Science Publishing Co Inc
Country of Publication: US
Dimensions (cm): 22.9 x 15.2  x 2.3
Weight (kg): 0.69