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Neuropet : Positron Emission Tomography in Neuroscience and Clinical Neurology - Karl Herholz


Positron Emission Tomography in Neuroscience and Clinical Neurology

Book with Other Items Published: 16th June 2004
ISBN: 9783540006916
Number Of Pages: 297

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Positron emission tomography (PET) provides unbiased in vivo measurement of local tracer activity at very high sensitivity. This is a unique property unmatched by other imaging modalities. When PETwas introduced into medicine more than 25years ago, the first organ of major interest was the brain. Since then, PET has flourished as an extremely powerful and versatile tool in scientific brain studies, whereas its use as a diagnostic tool in clinical neurology remains limited. This is in contrast to its use in otherapplications, particularlyoncology, where its value in clinical diagnosis is more widely appreciated. Wethink this situation is unfortu- nate, because PET can contribute more to clinical neurology and clinical neuro- science than is generally perceived today. Realization of its potential will require very close cooperation between PETexperts and clinicians and the integration of PET into clinical studies. Thus, in this book we review PETin neuroscience, with particular emphasis on findings that indicate its potential for improving diagno- sis and treatment in neurology and psychiatry. We want to improve the trans- ferability of the enormous scientific advances in brain PET into clinical care so as to produce tangible human benefit [1]. Wewish to guide both nuclear medicine specialists and also neurologists and psychiatrists in the use of PET. We there- fore focus on practical and potentially clinically relevant issues, identifying solid ground as well as open questions that require further research, and we see this targeted presentation as complementary to more general PET textbooks and reviews.

Industry Reviews

From the reviews:

This is the most comprehensive book written to date which reviews applications of PET in brain disorders, measurements of regional brain function, molecular imaging and PET methodology.

Rarer states are reviewed as well as those not normally considered as presenting with functional brain lesions such as pain and migraine.

For those with clinical PET facilities, this book will indentify how this technology could be exploited for the care of brain disorder patients.

RAD Magazine, December, 2005

"This book is by world authorities in both the methodology of positron emission tomography (PET) and its applications in clinical neurology. According to the authors, it is intended to 'guide both nuclear medicine specialists and also neurologists and psychiatrists in the use of PET'; I assume they also meant to include neurosurgeons, neurophysiologists and clinical neuroscientists. ... This book is unique in its kind. ... it will prove an invaluable source of historical information about one of the major revolutions in understanding brain diseases." (J. -C. Baron, Acta Neurochirurgica, Vol. 147, 2005)

Introductionp. 1
Clinical Studiesp. 7
Dementia and Memory Disordersp. 7
Clinical and Research Issuesp. 7
Alzheimer's Disease and Mild Cognitive Impairmentp. 9
Cerebral Glucose Metabolismp. 9
Cholinergic Degenerationp. 20
Other Receptors and Transmittersp. 22
Amyloid Imagingp. 22
Activation Studiesp. 23
Dementia with Lewy Bodiesp. 24
Frontotemporal Dementia and Related Disordersp. 25
Vascular Dementiap. 28
Creutzfeldt-Jakob Diseasep. 30
Other Memory Disordersp. 31
Hypoxic and Global Ischemic Brain Damagep. 31
Other Amnesic Syndromesp. 31
Movement Disordersp. 32
Idiopathic Parkinson Diseasep. 35
Diagnostic Issuesp. 35
Dopamine Synthesisp. 37
Dopamine Release and Turnoverp. 39
Dopamine Transportersp. 39
Vesicular Monoamine Transporterp. 40
Dopamine Receptorsp. 40
Mesocortical Dopaminergic Innervationp. 41
Other Transmittersp. 41
Resting Glucose Metabolismp. 41
Activation Studiesp. 42
Familial PDp. 42
Disease Progressionp. 44
Depression in PDp. 45
Improving and Understanding Treatment Effectsp. 45
Multiple System Atrophyp. 48
Olivo-ponto-cerebellar Atrophyp. 49
Striatonigral Degenerationp. 50
Shy-Drager Syndromep. 50
Other Neurodegenerative Disordersp. 52
Progressive Supranuclear Palsyp. 52
Corticobasal Degenerationp. 53
Disorders with Abnormal Deposition of Metalsp. 55
Parkinsonism Attributable to Toxic and Inflammatory Brain Damagep. 55
Amyotrophic Lateral Sclerosisp. 56
Other Rare Disordersp. 56
Hyperkinetic Syndromesp. 56
Huntington's Chorea (Huntington Disease)p. 56
Other Choreic Disordersp. 58
Restless Legs Syndromep. 58
Essential and Orthostatic Tremorp. 59
Tourette Syndromep. 59
Dystonia and Related Disordersp. 60
Idiopathic Dystonia and Torticollisp. 60
DOPA-responsive Dystoniap. 61
Dystonia Attributable to Localized Lesions or Degenerationp. 61
Ataxiap. 61
Spinocerebellar Ataxiap. 62
Friedreich's Ataxiap. 63
Other Ataxiasp. 63
Brain Tumorsp. 63
Biological Gradingp. 64
Glucose Consumptionp. 64
Amino Acid Uptakep. 68
Nucleoside Uptakep. 71
PET-Guided Stereotactic Biopsyp. 71
Differentiation Between Recurrent Tumor and Radiation Necrosisp. 71
Monitoring of Therapyp. 73
Identification of Hypoxic Tumor Tissuep. 77
Improving and Planning Therapyp. 77
New Therapiesp. 79
Other Tracers for Brain Tumorsp. 80
Extracranial Tumors of the Nervous Systemp. 80
Detection of Primary Tumorsp. 81
Activation Studiesp. 81
Motor Functionp. 82
Languagep. 84
Cerebrovascular Diseasep. 86
Ischemic Strokep. 87
Intracerebral and Subdural Hemorrhagep. 89
Subarachnoid Hemorrhagep. 90
Remote Effects (Diaschisis)p. 90
Chronic Hemodynamic Impairmentp. 93
Moyamoya Diseasep. 95
Genetic Disorders (MELAS, CADASIL)p. 95
Brain Function and Recovery After Strokep. 95
Aphasiap. 96
Motor Functionp. 98
Neglectp. 99
Epilepsyp. 100
Localization of Epileptogenic Focip. 101
Temporal Lobe Epilepsyp. 101
Neocortical Focal Epilepsyp. 105
Ictal Studiesp. 105
GABA-A and Benzodiazepine Receptorsp. 106
Other Transmitters and Receptorsp. 107
Inflammatory Lesions and Glial Reactionp. 108
Progression of Epileptic Lesionsp. 109
Prediction of Surgical Outcomep. 109
Malformations of Cortical Developmentp. 109
Childhood Epileptic Syndromesp. 111
Language Dominancep. 112
Effects of Surgical Intervention and Medical Treatmentp. 112
Generalized Epilepsyp. 113
Other Neurological Disordersp. 113
Traumatic Brain Injuryp. 113
Persistent Vegetative Statep. 114
Perinatal Brain Damagep. 115
Inflammatory Diseasep. 117
Painp. 119
Migraine and Cluster Headachep. 121
Narcolepsyp. 122
Hypoparathyroidism (Fahr's Disease)p. 122
Systemic Inherited Metabolic Disordersp. 122
Psychiatric Disordersp. 123
Depressionp. 124
Cerebral Blood Flow and Cerebral Metabolic Rate (Glucose)p. 125
Serotonin Receptorsp. 127
Serotonin Transportersp. 128
Other Transmitter Systemsp. 128
Fatiguep. 128
Schizophreniap. 129
CBF and Energy Metabolismp. 129
Activation Studiesp. 129
Dopamine Receptors and Dopamine Releasep. 130
Other Receptorsp. 131
Receptor Binding of Antipsychotic Drugsp. 131
Anxiety Disordersp. 131
Panic Disorderp. 132
Phobic Disordersp. 132
Obsessive-compulsive Disorderp. 133
Posttraumatic Stress Disorderp. 134
Drug and Substance Abusep. 135
Alcoholismp. 135
Cocainep. 136
Amphetamine and Derivativesp. 138
Opiatesp. 139
Nicotinep. 140
Hallucinogensp. 140
Phencyclidinep. 140
Personality and Behavioral Disordersp. 141
Borderline Personality Disorderp. 141
Violence and Suicidep. 141
Anorexia Nervosa and Bulimiap. 142
Imaging Brain Functionp. 143
Blood-Brain Barrier Transferp. 143
Cerebral Blood Flowp. 147
Oxygen Consumptionp. 149
Glucose Consumptionp. 150
Influence of Brain Function on CBF and Metabolismp. 152
Wakefulness and Sleepp. 153
Effect of Drugsp. 153
The “Resting State”p. 154
Activation Studiesp. 155
Tissue Oxygen Pressure and pHp. 156
Amino Acid Transport and Protein Synthesisp. 156
Transport-only Tracersp. 157
Tracers with Incorporation into Proteinsp. 158
Precursors and Analogues for Transmitter Systemsp. 160
Nucleosides and DNA Synthesisp. 160
Molecular Imagingp. 161
Herpes Simplex Virus Thymidine Kinase Imagingp. 163
Reporter Gene Imagingp. 164
Oligonucleotidesp. 164
Apoptosis and p53p. 164
Cell Traffickingp. 164
Angiogenesisp. 165
Dopamine Systemp. 165
Precursors and Analogues of Dopaminep. 165
Dopamine Transporterp. 167
Vesicular Monoamine Transporterp. 168
D1 Receptorsp. 169
D2 Receptorsp. 169
Studies of Synaptic Dopamine Releasep. 170
Monoamine Oxidasep. 172
Cholinergic Systemp. 173
Acetylcholine Synthesisp. 173
Vesicular Acetylcholine Transporterp. 173
Nicotinic Receptorsp. 173
Muscarinic Receptorsp. 174
Acetylcholine Esterasep. 174
Serotonin Systemp. 176
Serotonin Precursorsp. 176
Serotonin Transporterp. 177
Serotonin Receptorsp. 177
Serotonin 1A Receptorsp. 177
Serotonin 2A Receptorsp. 180
Gamma-aminobutyric acid (GABA)p. 180
Central Benzodiazepine-binding Sitesp. 181
Peripheral Benzodiazepine Receptorsp. 181
Glutamate and NMDA Receptorsp. 182
Adenosine Receptorsp. 182
Histamine Receptorsp. 182
Cannabinoid Receptorsp. 183
Opioid Receptors and Sigma Receptorp. 183
Steroid Receptorsp. 184
Substance Pp. 184
Secondary Neurotransmittersp. 185
Data Acquisition, Reconstruction, Modeling, Statisticsp. 187
Positron Emitters and Tracersp. 187
Scanners and Detector Systemsp. 189
Data Acquisitionp. 191
Image Reconstructionp. 192
Motion Detection and Correctionp. 194
Data Visualizationp. 194
Image Coregistrationp. 195
Fiducial Markersp. 196
Matching of Brain Structuresp. 197
Algorithms for Maximization of Similarityp. 198
PET/CT and PET/MRI Scannersp. 199
Anatomical Standardizationp. 200
Orientation of Transaxial Slicesp. 200
Matching of Individual Brains to Image Templates (“Spatial Normalization”)p. 201
Atlases for Identification of Anatomical Structuresp. 202
Physiological Modelingp. 203
Blood and Homogeneous Tissue (One Tissue Compartment)p. 205
Transport across the BBBp. 206
Cerebral Blood Flowp. 207
Mixed Effects of Transport and Blood Flowp. 211
Measurement of the Partition Coefficientp. 211
Saturable Transport and Enzyme Reactionsp. 212
Metabolismp. 212
Irreversible Metabolism (Metabolic Trapping)p. 213
Measurement of Local Cerebral Glucose Metabolismp. 214
The Reference Tissue Model for Dopamine Synthesis and Storagep. 216
Reversible Metabolism or Bindingp. 217
Receptor Bindingp. 218
Irreversible Receptor Bindingp. 219
Equilibrium Approaches for Quantification of Reversible Receptor Bindingp. 220
Extraction of Model Parameters from Kinetic Datap. 222
Quantitative Data Analysisp. 223
Regions/Volumes of Interestp. 225
Partial Volume Correctionp. 226
Statistical Models for Quantitative Datap. 227
Parametric Imagingp. 231
Statistical Parametric Mappingp. 232
Lesion Detection and Pattern Recognitionp. 233
Referencesp. 235
Subject Indexp. 285
Table of Contents provided by Publisher. All Rights Reserved.

ISBN: 9783540006916
ISBN-10: 3540006915
Audience: General
Format: Book with Other Items
Language: English
Number Of Pages: 297
Published: 16th June 2004
Country of Publication: DE
Dimensions (cm): 24.23 x 16.87  x 1.96
Weight (kg): 0.72