After a little more than 20 years since the original discovery of neuropeptide Y (NPY) by Tatemoto and colleagues, the field of NPY research has made remarkable progress and is coming of age.The present volume addresses all major topics in connection with NPY and related peptides by established leaders in their respective areas. Experienced NPY-aficionados will certainly find new and useful additional information in this volume and newcomers to the field will hopefully discover how much exciting research this still has to offer.
Preface.- Neuropeptide Y: History and Overview.- PP, PYY and NPY: Synthesis, Storage, Release and Degradation.- NPY Receptor Subtypes and Their Signal Transduction.- Phylogenesis of NPY-like Peptides and Their Receptors.- NPY-like Peptides and Their Receptor in the Central Nervous System.- Prejunctional Effects of NPY and Role as a Cotransmitter.- Neuroendocrine Actions of Neuropeptide Y (NPY).- NPY: A Novel On/Off Switch for Control of Appetite and Reproduction.- Behavioural Effects of NPY.- NPY in the Regulation of Food Intake and Metabolism.- NPY-like Peptides and Cardiovascular Function.- Neuropeptide Y and the Kidney.- NPY-like Peptides and Gastrointestinal Function.- NPY and Immune Functions: Implications for Health and Diseases.- Transgenic and Knockout Models in NPY Research.- Structure-Activity Relationship of Peptide-Derived Ligands at NPY Receptors.- Structure-Activity of Relationships of Non-Peptide NPY Receptor Antagonists.
Series: Handbook of Experimental Pharmacology
Number Of Pages: 555
Published: 4th October 2012
Publisher: Springer-Verlag Berlin and Heidelberg Gmbh & Co. Kg
Country of Publication: DE
Dimensions (cm): 23.5 x 15.5
Weight (kg): 0.86