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Neuropathology and Genetics of Dementia : Advances in Experimental Medicine and Biology - Markus Tolnay

Neuropathology and Genetics of Dementia

Advances in Experimental Medicine and Biology

By: Markus Tolnay (Editor), Alphonse Probst (Editor)

Hardcover Published: 31st May 2001
ISBN: 9780306465581
Number Of Pages: 255

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these "tauopathies" are reviewed by Delacourte. Therecentdiscoverythatmutationsofthetaugenearecausativeforfamilial formsoffrontotemporaldementiaandParkinsonism(FTDP-17)broughtthe "taupathway"and the"tauopathies"tothecentrestage.Thisextraordinary breakthroughwillbecoveredbySpillantiniandGoedert.Thereisincreasing evidence that argyrophilic grain disease is much more frequent in older patients than previously thought. Tolnay et al. are reviewing recent contributionstothepathologyofthislate-onsetdementingdisorderinwhich ofamyloidbetadeposits,isalmost taupathology,inthealmosttotalabsence exclusivelyrestricted to the limbic lobe and the amygdala. Schultzet al. report an intriguing age-related progression of neuronal and glial tau pathologyinbaboonsthusrenderingthe baboonapotentialprimatemodel forage-relatedhuman"tauopathies". Gotzetal. introducetransgenicmice expressingmutated human tau as valuable animal models for reproducing formationofneuro-andglialfibrillarylesions.

Can the Physician Predict the Neuropathologist?p. 1
The Molecular Parameters of Tau Pathology: Tau as a killer and a witnessp. 5
Tau Gene Mutations and Tau Pathology in Frontotemporal Dementia and Parkinsonism Linked to Chromosome 17p. 21
Argyrophilic Grain Disease: A frequent dementing disorder in aged patientsp. 39
Tau Pathology in Neurons and Glial Cells of Aged Baboonsp. 59
Human Tau Transgenic Mice: Towards an animal model for neuro- and glialfibrillary lesion formationp. 71
Regulation of Alzheimer [beta]-Amyloid Precursor Trafficking and Metabolismp. 85
Role of Type 10 17[beta]-Hydroxysteroid Dehydrogenase in the Pathogenesis of Alzheimer's Diseasep. 101
The Spectrum of Vascular Disease in Dementia: From ischemia to amyloid angiopathyp. 111
Transgenic Mouse Models of Cerebral Amyloid Angiopathyp. 123
Alpha-Synuclein: Axonal transport, ligand interaction and neurodegenerationp. 129
Dementia with Lewy Bodiesp. 135
Mouse Models of [alpha]-Synucleinopathy and Lewy Pathology: [alpha]-synuclein expression in transgenic micep. 147
Ubiquitin and the Molecular Pathology of Neurodegenerative Diseasesp. 169
Perisomatic Granules of Hippocampal Ca1 Neurons in Alzheimer's Disease, Pre-Alzheimer Stage and Pick's Disease: an Overlooked Pathological Entityp. 187
Pathological Mechanisms in Polyglutamine Expansion Diseasesp. 199
Dementia in the Neuronal Ceroid-Lipofuscinosesp. 211
Neurodegeneration-Associated Proteins and Inflammation in Sporadic Inclusion-Body Myositisp. 219
Mitochondrial Dysfunction in Neurodegenerative Disorders and Ageingp. 229
Indexp. 253
Table of Contents provided by Syndetics. All Rights Reserved.

ISBN: 9780306465581
ISBN-10: 0306465582
Series: Advances in Experimental Medicine and Biology
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 255
Published: 31st May 2001
Publisher: Springer Science+Business Media
Country of Publication: US
Dimensions (cm): 25.4 x 17.8  x 2.54
Weight (kg): 1.62