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Neuronal Networks of the Hippocampus - Roger D. Traub

Neuronal Networks of the Hippocampus

Hardcover Published: 31st May 1991
ISBN: 9780521364812
Number Of Pages: 304

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The questions of how a large population of neurons in the brain functions, how synchronized firing of neurons is achieved, and what factors regulate how many and which neurons fire under different conditions form the central theme of this book. Using a combined experimental-theoretical approach unique in neuroscience, the authors present important new techniques for the physiological reconstruction of a large biological neuronal network. They begin by discussing experimental studies of the CA3 hippocampal region in vitro, focusing on single-cell and synaptic electrophysiology, particularly the effects a single neuron exerts on its neighbors. This is followed by a description of a computer model of the system, first for individual cells then for the entire detailed network, and the model is compared with experiments under a variety of conditions. The results shed significant light into the mechanisms of epilepsy, electroencephalograms, and biological oscillations and provide an excellent test case for theories of neural networks.

"...integrates experiments and computer modeling into seamless fabric, something still rare in the neurosciences. The use of arguments from statistical physics and dynamical systems theory is compelling and to the point. The monograph should be required reading for any researcher seriously interested in networks of complicated and highly interconnected neurons..." Christof Koch, Science "Traub and Miles are to be congratulated not only for the intellectual and empirical achievements embodied in this book, but also for the delicate balance struck between detail and clarity." Bruce L. McNaughton, Trends in Neuroscience

Acknowledgments
Prologue
The hippocampus in context
Physiology of single neurons: voltage- and ligand-gated ionic channels
Synaptic function and organization of the CA3 region
The single-cell model
Model of the CA3 network
Collective behaviours of the CA3 network: experiment and model
Collective behaviours of the CA3 network: spontaneous oscillations and synchronized synaptic potentials
Field effects
Theoretical approaches: mathematical neural networks
Appendix
Conclusion
Notes
References
Index
Table of Contents provided by Publisher. All Rights Reserved.

ISBN: 9780521364812
ISBN-10: 0521364817
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 304
Published: 31st May 1991
Publisher: CAMBRIDGE UNIV PR
Country of Publication: GB
Dimensions (cm): 22.86 x 15.24  x 2.06
Weight (kg): 0.62