Neuroinflammatory Mechanisms in Alzheimer's Disease : Basic and Clinical Research : Basic and Clinical Research - Joseph Rogers

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Neuroinflammatory Mechanisms in Alzheimer's Disease : Basic and Clinical Research

Basic and Clinical Research

By: Joseph Rogers (Editor)

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Hardcover | 1 December 2000

At a Glance

Hardcover
284 Pages

Dimensions(cm)
22.86 x 16.51 x 1.91

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$139.00

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There has been an increasing appreciation of the economic and human toll that age-related disorders take throughout the world. Unprecedented research efforts have followed, aiming at the understanding and treatment of Alzheimer's Disease (AD) in particular, and this effort has finally begun to bear fruit - sometimes in surprising ways: Twenty years ago, the idea that AD involved any sort of inflammatory or immune component seemed implausible, if considered at all. Now, there are hundreds of laboratories world-wide that are pursuing basic research in this area, and multi-site clinical trials are underway to test the therapeutic potential of common anti-inflammatory drugs in AD. How this dramatic sea-change came about is made clear in this book, both through overviews of the field and through focused papers on specific topics of recent interest. Complement, cytokines and the complex host of other acute phase reactants are covered, as are summaries of many epidemiologic and clinical-pathological findings...

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You Can Find This Book In

Non-Fiction Medicine Clinical & Internal Medicine Neurology & Clinical Neurophysiology Diseases & Disorders Immunology Geriatric Medicine Medicine in General

List of contributors
Preface
Cellular and molecular mechanisms of Alzheimer's disease inflammation	p. 3
Anti-inflammatory agents as possible protective factors for Alzheimer's disease: Analysis of relevant epidemiological studies	p. 53
Role and regulation of early complement activation products in Alzheimer's disease	p. 67
Complement mediator systems in Alzheimer's disease	p. 89
Amyloid [beta] peptide interactions with the classical pathway of complement	p. 105
Physiology and biochemistry of the interleukin-6 receptor complex: implications for CNS disorders and Alzheimer's disease	p. 121
Interactions of [alpha]2-macroglobulin and amyloid [beta] peptide	p. 145
Proinflammatory actions of derivatives of the [beta] amyloid precursor protein	p. 155
The involvement of glial cell-derived reactive oxygen and nitrogen species in Alzheimer's disease	p. 173
The role of cyclooxygenase in Alzheimer's disease neurodegeneration	p. 197
Microglia	p. 209
Neurons	p. 225
The gero-inflammatory manifold	p. 237
Index	p. 257
Table of Contents provided by Blackwell. All Rights Reserved.

Neuroinflammatory Mechanisms in Alzheimer's Disease : Basic and Clinical Research

Basic and Clinical Research

At a Glance

Hardcover

Shipping

How to return your order

Defective items

You Can Find This Book In

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