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Neuroinflammation : Mechanisms and Management - Paul L. Wood


Mechanisms and Management

By: Paul L. Wood (Editor)

Hardcover Published: 18th December 2002
ISBN: 9781588290021
Number Of Pages: 420

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In this thoroughly updated and revised edition of his much praised book, Paul L. Wood and a panel of leading researchers capture these new developments in a masterful synthesis of what is known today about the inflammatory mediators and cells involved in neurodegenerative diseases. This second edition contains extensive updates on the mediators produced by microglia and their role in neuroinflammatory-induced neuronal lysis. There is also increased coverage of the animal models used in the study of neuroinflammatory mechanisms, of the new imaging methods that allow the noninvasive evaluation of microglial activation in human neurodegernerative disorders, and of the role of neuroinflammation in amyloid-dependent neuronal lysis.

Industry Reviews

Review of the first edition:
..".will reach a wide audience including basic and clinical neuroscientists. . .fills a significant gap in the literature...provides an excellent starting point, and offers insight into the rapid pace of discovery within a field which influences most aspects of nervous system function."-Nature Medicine

..".fills a significant gap in the literature...provides an excellent starting point..."
-Nature Medicine

..".will be useful to a wide variety of researchers and clinicians, particularly [those] interested in neurodegenerative disorders ..."
-Neurological Research

..".provides a thorough overview of cells and mechanisms of brain inflammation, their role in disease and future therapeutic avenues to overcome it."
-Microbiology Today

..".a timely addition that will aid our understanding today."
-Receptors & Signal Transduction

Prefacep. v
Contributorsp. ix
Neuroinflammatory Mechanisms
Microglia: Roles of Microglia in Chronic Neurodegenerative Diseasesp. 3
Apoptosis vs Nonapoptotic Mechanisms in Neurodegenerationp. 29
Role(s) of Mitogen and Stress-Activated Kinases in Neurodegenerationp. 89
Roles of Chemokines and Their Receptors in Neuroinflammationp. 99
Neurotoxic Mechanisms of Nitric Oxidep. 117
Chronic Intracerebral LPS as a Model of Neuroinflammationp. 137
Peroxisome Proliferator-Activated Receptor Gamma Agonists: Potential Therapeutic Agents for Neuroinflammationp. 151
Neuroinflammation-Mediated Neurotoxin Production in Neurodegenerative Diseases: Potential of Nitrones as Therapeuticsp. 171
Stroke and TBI
Inflammation and Potential Anti-Inflammatory Approaches in Strokep. 189
Neuroinflammation as an Important Pathogenic Mechanism in Spinal Cord Injuryp. 215
Type IV Collagenases and Blood-Brain Barrier Breakdown in Brain Ischemiap. 237
Alzheimer's Disease
Neuroinflammatory Environments Promote Amyloid-beta Deposition and Posttranslational Modificationp. 249
Microglial Responses in Alzheimer's Disease: Recent Studies in Transgenic Mice and Alzheimer's Disease Brainsp. 267
The Amyloid Hypothesis of Cognitive Dysfunctionp. 283
The Cerebellum in AD: A Case for Arrested Neuroinflammation?p. 295
The Neuroinflammatory Components of the Trimethyltin (TMT) Model of Hippocampal Neurodegenerationp. 301
Inflammation and Cyclo-Oxygenase in Alzheimer's Disease: Experimental Approaches and Therapeutic Implicationsp. 331
Multiple Sclerosis
Experimental Autoimmune Encephalomyelitisp. 345
Neuroimmunologic Mechanisms in the Etiology of Multiple Sclerosisp. 359
In Vivo Imaging of Neuroinflammation in Neurodegenerative Diseasesp. 379
Parkinson's and Huntington's Diseases
Inflammatory Mechanisms in Parkinson's Diseasep. 391
Neuroinflammatory Components of the 3-Nitropropionic Acid Model of Striatal Neurodegenerationp. 405
Indexp. 417
Table of Contents provided by Syndetics. All Rights Reserved.

ISBN: 9781588290021
ISBN-10: 1588290026
Series: Contemporary Neuroscience
Audience: General
Format: Hardcover
Language: English
Number Of Pages: 420
Published: 18th December 2002
Publisher: Humana Press Inc.
Country of Publication: US
Dimensions (cm): 27.03 x 17.88  x 2.87
Weight (kg): 1.03
Edition Number: 2
Edition Type: Revised