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Neuroimmune Circuits, Drugs of Abuse, and Infectious Diseases : Neuroimmune Circuits, Drugs of Abuse, and Infectious Diseases Proceedings of the 7th International Conference on Neuroimmune Circuits, Drugs of Abuse and Infectious Diseases Held on October 7-9 1999 in Bethesda, Maryland USA - Herman Friedman

Neuroimmune Circuits, Drugs of Abuse, and Infectious Diseases

Neuroimmune Circuits, Drugs of Abuse, and Infectious Diseases Proceedings of the 7th International Conference on Neuroimmune Circuits, Drugs of Abuse and Infectious Diseases Held on October 7-9 1999 in Bethesda, Maryland USA

By: Herman Friedman (Editor), Thomas W. Klein (Editor), John J. Madden (Editor)

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Published: 30th November 2001
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Introduction and Perspectives This volume is based on the proceedings of the 7th annual symposium on the topic Neuroimmune Circuits, Infectious Diseases and Drugs of Abuse, Bethesda, Maryland, Oc- ber 7-9, 1999. This symposium, as in the past, focused on newer knowledge concerning the relationship between the immune and nervous systems with regards to the effects of drugs of abuse and infections, including AIDS, caused by the immunodeficiency virus. Presentations discussed the brain-immune axis from the viewpoint of drugs of abuse rather than from the subject of the brain or immunity alone. The major aim of this series of conferences has been to clarify the consequences of immunomodulation induced by drugs of abuse in regards to susceptibility and pathogenesis of infectious diseases, both in man and in various animal model systems. The recreational use of drugs of abuse such as morphine, cocaine, and marijuana by large numbers of individuals in this country and around the world has continued to arouse serious concerns about the consequences of use of such drugs, especially on the normal physiological responses of an individual, including immune responses. Much of the recent data accumulated by investigators show that drugs of abuse, especially opioids and cannabinoids, markedly alter immune responses in human populations as well as in experimental animals, both in vivo and in vitro.

Targeting the Brain's Immune System: A Psychopharmacological Approach to Central Nervous System Infectionsp. 1
Model Systems for Assessing Cognitive Function: Implications for HIV-1 Infection and Drugs of Abusep. 7
Direct and Indirect Mechanisms of HIV-1 Neuropathogenesis in the Human Central Nervous Systemp. 29
Chemokine Receptors on Brain Endothelia - Keys to HIV-1 Neuroinvasion?p. 35
Neurotrofic Factor Regulation of Human Immunodeficiency Virus Type 1 Replication in Human Blood-Derived Macrophages through Modulation of Coreceptor Expressionp. 41
Direct vs. Indirect Modulation of Complex In vitro Human Retroviral Infections by Morphinep. 49
Genetic Factors Involved in Central Nervous System/Immune Interactionsp. 59
Interactions of Opioid Receptors, Chemokines and Chemokine Receptorsp. 69
Crosstalk between Chemokine and Opioid Receptors: Results in Down-modulation of Cell Migrationp. 75
Morphine Upregulates Kappa-Opioid Receptors of Human Lymphocytesp. 81
Effects of Morphine on T-Cell Recirculation in Rhesus Monkeysp. 89
Mitogen-Induced Activation of Mouse T Cells Increases Kappa Opioid Receptor Expressionp. 103
Self-Enhancement of Phagocytosis by Murine Resident Peritoneal Macrophages and Its Relationship to Morphine Effects on the Processp. 111
Role of Mu-Opioid Receptor in Immune Functionp. 117
Opiates Promote T Cell Apoptosis through JNK and Caspase Pathwayp. 127
Role of Beta-Endorphin in the Modulation of Immune Responses: Perspectives in Autoimmune Diseasesp. 137
Modulation of FAS/FASL in a Murine Retroviral Infection by AZT and Methionine Enkephalinp. 143
Acute Effects of Heroin on the Cellularity of the Spleen and the Apoptosis of Splenic Leukocytesp. 153
Alteration of Early T Cell Development by Opioid and Superantigen Stimulationp. 163
Effect of Opioids on Oral Salmonella Infection and Immune Functionp. 169
Altered T-Cell Responsiveness in Morphine "Tolerant" Rats: Evidence for a Potential Role of the Paraventricular Nucleus of the Hypothalamusp. 177
Actions of Endotoxin and Morphinep. 187
Pharmaconeuroimmunology in the Intestinal Tract: Opioid and Cannabinoid Receptors, Enteric Neurons and Mucosal Defensep. 197
Cannabinoid-Mediated Inhibition of Inducible Nitric Oxide Production by Rat Microglial Cells: Evidence for CB[subscript 1] Receptor Participationp. 207
Modulation of CB1 mRNA upon Activation of Murine Splenocytesp. 215
Downregulation of Cannabinoid Receptor 2 (CB2) Messenger RNA Expression during In vitro Stimulation of Murine Splenocytes with Lipopolysaccharidep. 223
CB1 and CB2 Receptor mRNA Expression in Human Peripheral Blood Mononuclear Cells (PBMC) from Various Donor Typesp. 229
Effect of Cocaine on Chemokine and CCR-5 Gene Expression by Mononuclear Cells from Normal Donors and HIV-1 Infected Patientsp. 235
Intravenous Cocaine Abuse: A Rodent Model for Potential Interactions with HIV Proteinsp. 241
Substance P Receptor Mediated Macrophage Responsesp. 247
Lymphocyte Modulation by Seven Transmembrane Receptors: A Brief Review of Session 1p. 255
NEUROAIDS Retroviral Pathology and Drugs of Abuse: Session Summaryp. 259
The Effects of Drugs and Neuropeptides on Immunomodulation and Opportunistic Infection: Summary of Symposium 2p. 263
Indexp. 265
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780306464669
ISBN-10: 0306464667
Series: Advances in Experimental Medicine and Biology
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 274
Published: 30th November 2001
Publisher: Springer Science+Business Media
Country of Publication: US
Dimensions (cm): 23.4 x 15.6  x 1.75
Weight (kg): 1.69