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Neurodegenerative Disorders : Loss of Function Through Gain of Function :  Loss of Function Through Gain of Function - Konrad Beyreuther

Neurodegenerative Disorders : Loss of Function Through Gain of Function

Loss of Function Through Gain of Function

By: Konrad Beyreuther (Editor), Yves Christen (Editor), Colin L. Masters (Editor)

Hardcover

Published: April 2001
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The main message from this book is that the different protein aggregation processes may all be amenable to a small number of intervention steps based on a common theme of the modulation of production, turnover and deposition of the corresponding disease gene products. The next few years will prove critical in evaluation the possibilities of rational therapeutic strategies towards regaining the loss of function through the amelioration of the abnormal gain of function.

The Natural History of Alzheimer's Disease: Minding the Gaps in Understanding the Mechanisms of Neurodegenerationp. 1
Mechanisms of Motor Neuron Death in ALSp. 23
Pathological Mechanisms in Huntington's Disease and Other Polyglutamine Expansion Diseasesp. 41
Prion Protein Biogenesis: Implications for Neurodegenerationp. 55
The Value of Transgenic Models for the Study of Neurodegenerative Diseasesp. 67
Pathogenesis and Mechanism of Cerebral Amyloidosis in APP Transgenic Micep. 87
Alzheimer's Disease: Physiological and Pathogenetic Role of the Amyloid Precursor Protein (APP), its [alpha][beta]-Amyloid Domain and Free [alpha][beta]-Amyloid Peptidep. 97
The NEXT step in Notch Processing and its Relevance to Amyloid Precursor Proteinp. 119
The Putative Role of Presenilins in the Transmembrane Domain Cleavage of Amyloid Precursor Protein and Other Integral Membrane Proteinsp. 129
ApoE Receptors in the Brain: Novel Signaling Pathways with Potential Relevance for Alzheimer's Diseasep. 141
Homeoprotein Intercellular Transport: Mechanisms, Significance and Applicationsp. 149
Overexpression of APPL, a Drosophila APP Homologue, Compromises Microtubule Associated Axonal Transport and Promote Synapse Formationp. 159
A Gain of Function of the Huntington's Disease and Amyotrophic Lateral Sclerosis - Associated Genetic Mutations May Be a Loss of Bioenergeticsp. 173
Subject Indexp. 187
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9783540412182
ISBN-10: 3540412182
Series: Studien Zur Sozialwissenschaft
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 189
Published: April 2001
Publisher: SPRINGER VERLAG GMBH
Country of Publication: DE
Dimensions (cm): 27.94 x 21.59  x 1.27
Weight (kg): 0.78