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Neurobiology of Disease - Sid Gilman

Neurobiology of Disease

Hardcover Published: 2nd November 2006
ISBN: 9780120885923
Number Of Pages: 1104

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This book is aimed at any basic scientist or clinician scientist teaching a course or conducting research on the basic science underlying the major neurological diseases. It provides an excellent overview of cutting-edge research on the fundamental disorders of the nervous system, including physiological and molecular aspects of dysfunction. The major categories of neurological disease are covered, and the chapters provide specific information about particular diseases exemplifying each of these categories. Sufficient clinical information is included to put into perspective the basic mechanisms discussed. The book assembles a world-class team of section editors and chapters written by acknowledged experts in their respective fields.
* Provides cutting edge information about fundamental mechanisms underlying neurological diseases
* Amply supplied with tables, illustrations and references
* Includes supporting clinical information putting the mechanisms of disease into perspective

Industry Reviews

"I think [the book] is very valuable, and it has benefited from careful editing and good organization. ...The illustrations are excellent - color has been used judiciously and effectively. ...The number of undergraduate neuroscience majors is growing, and a book of this type could be of great value to them. Neurology residents would find it a very quick way to get the background on which to superimpose new findings. ...Overall, I think the book does achieve the goals that Gilman proposed - he and his colleagues are to be congratulated." -Guy McKhann, MD, Johns Hopkins University in the NEW ENGLAND JOURNAL OF MEDICINE, May 30, 2007

Contributorsp. ix
Editorsp. xvi
Prefacep. xvii
Central Nervous System
Metabolic Diseases
Lysosomal Disorders of the Nervous Systemp. 1
Neurobiology of Peroxisomal Disordersp. 19
Creatine Deficiency Syndromesp. 33
Leukodystrophiesp. 43
Neurodegenerative Disorders
Parkinson's Diseasep. 51
Alzheimer's Diseasep. 69
Multiple System Atrophyp. 83
Olivopontocerebellar Atrophy (OPCA)p. 95
Neurobiology of Progressive Supranuclear Palsyp. 105
Genetic Diseases
Protein Aggregation Disordersp. 111
RNA-Based Disorders of Muscle and Brainp. 125
Ion Channel Disordersp. 135
Spinocerebellar Ataxia Type 1p. 149
Mitochondrial Genetic Diseasesp. 157
Neuroimmunological Disorders
Paraneoplastic Neurological Disordersp. 163
Systemic Lupus Erythematosus: Descriptive Past and Mechanistic Futurep. 171
Progressive Multifocal Leukoencephalopathyp. 185
Immunopathogenesis of Multiple Sclerosisp. 197
Immune-Mediated Neuropathiesp. 205
Hashimoto Encephalopathyp. 217
Cerebrovascular Diseases
Vascular Cognitive Impairmentp. 223
Cardioembolismp. 235
Clinical and Neurobiological Aspects of Stroke Recoveryp. 241
Nonatherosclerotic Cerebral Vasculopathiesp. 255
Subarachnoid Hemorrhagep. 265
Cerebral Ischemia: Molecular Mechanisms and Protective Therapiesp. 271
Intracerebral Hemorrhage and Intraventricular Hemorrhage-Induced Brain Injuryp. 281
Paroxysmal Disorders
Idiopathic Generalized Epilepsyp. 289
Paroxysmal Dyskinesiap. 297
Myoclonusp. 305
Channelopathies of the Nervous Systemp. 319
Migraine as a Cerebral Ionopathy with Abnormal Central Sensory Processingp. 333
Temporal Lobe Epilepsyp. 349
Neoplastic Diseases
Central Nervous System Metastasesp. 371
Meningiomap. 381
Primary Central Nervous System Lymphomap. 395
Neurofibromatosis 1p. 413
Medulloblastoma and Primitive Neuroectodermal Tumorsp. 425
Gliomap. 433
Infectious Diseases
Bacterial and Fungal Infections of the Nervous Systemp. 445
Parasitic Infectionsp. 453
Prion Diseasesp. 473
Central Nervous System Viral Infections: Clinical Aspects and Pathogenic Mechanismsp. 485
Motor Neuron Diseases
Spinal Muscular Atrophyp. 501
Amyotrophic Lateral Sclerosis-Like Syndromes Associated with Malignancyp. 513
Amyotrophic Lateral Sclerosis: Idiopathic and Inheritedp. 521
Hereditary Spastic Paraplegia and Primary Lateral Sclerosisp. 537
Poliomyelitisp. 545
Spinobulbar Muscular Atrophy (Kennedy's Disease)p. 553
Malformations and Developmental Disorders
Neurobiology of Genetic Mental Retardationp. 563
Cerebral Palsyp. 575
Autismp. 581
Neurobiology of Dyslexiap. 593
Neonatal Brain Injuriesp. 599
Spina Bifidap. 611
Circuits to Synapses: The Pathophysiology of Tourette Syndromep. 619
Attention-Deficit Hyperactivity Disorderp. 631
Congenital Hydrocephalusp. 641
Neurologic Manifestations of Medical Diseases
Neurological Manifestations of Hematological Diseasep. 649
Neurological Manifestations of Renal Diseasep. 659
Diabetes and Endocrine Disordersp. 669
Mechanisms and Consequences of Central Nervous System Hypoxiap. 681
Neurological Manifestations of Gastrointestinal and Hepatic Diseasesp. 689
Neurosarcoidosisp. 703
Sleep Disorders
REM Sleep Behavior Disorderp. 709
Neurobiology of Narcolepsy and Hypersomniap. 715
Restless Legs Syndrome and Periodic Limb Movements in Sleepp. 723
Neurobiology of Insomniap. 735
Substance Abuse and Basic Toxicology
Organic Chemicalsp. 745
Metalsp. 759
Neurobiology of Drug Addictionp. 771
Imaging the Nervous System
Assessment of Neurobiological Diseases with Magnetic Resonance Spectroscopyp. 781
Magnetic Resonance Imagingp. 793
Neurovascular Computed Tomography Angiographyp. 801
PET Imaging in Parkinson's Disease and Other Neurodegenerative Disordersp. 821
Single-Photon Emission Computed Tomographyp. 829
Functional Magnetic Resonance Imagingp. 839
Peripheral Nervous System
Peripheral Neuropathies
Impaired Glucose Regulation and Neuropathyp. 849
Acquired Inflammatory Demyelinating and Axonal Neuropathiesp. 859
Toxic and Drug-Induced Neuropathiesp. 871
Inherited Peripheral Neuropathiesp. 885
Neurological Manifestations of Vasculitisp. 901
Neuropathies Associated with Infectionsp. 913
Myopathies and Neuromuscular Junction Disorders
Muscular Dystrophiesp. 925
Myasthenia Gravis and Myasthenic Syndromesp. 935
Metabolic Myopathiesp. 947
Immunobiology of Autoimmune Inflammatory Myopathiesp. 957
Autonomic Disorders
Central Autonomic Networkp. 969
Autonomic Neuropathiesp. 979
Thermoregulation and Its Disordersp. 987
Control of Blood Pressure-Normal and Abnormalp. 997
Neoplasm-Induced Painp. 1007
Pain Associated with the Autonomic Nervous Systemp. 1021
Postherpetic Neuralgiap. 1031
Central Post-Stroke Painp. 1039
Indexp. 1047
Table of Contents provided by Ingram. All Rights Reserved.

ISBN: 9780120885923
ISBN-10: 0120885921
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 1104
Published: 2nd November 2006
Publisher: Elsevier Science Publishing Co Inc
Country of Publication: US
Dimensions (cm): 27.9 x 21.6  x 4.6
Weight (kg): 2.51